Calcitonin-loaded octamaleimic acid–silsesquioxane nanoparticles in hydrogel scaffold support osteoinductivity in bone regeneration

Ahmadipour, Saeedeh; Varshosaz, Jaleh; Hashemibeni, Batool; Safaeian, Leila; Manshaei, Maziar; Sarmadi, Akram

doi:10.1080/10837450.2020.1858318

Cited by 10 publications

(3 citation statements)

References 60 publications

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“…However, these materials still consist of aromatic MDI 107 . Recent studies have shown that POSS is effective as an osteoinductive modifier, allowing the biomaterials to bind and facilitate bone formation 107–118 . POSS was found to enhance osteoblast adhesion, osteocalcin production by cellular biomineralization, and alkaline phosphatase activity 115,119 .…”

Section: Introductionmentioning

confidence: 99%

“…107 Recent studies have shown that POSS is effective as an osteoinductive modifier, allowing the biomaterials to bind and facilitate bone formation. [107][108][109][110][111][112][113][114][115][116][117][118] POSS was found to enhance osteoblast adhesion, osteocalcin production by cellular biomineralization, and alkaline phosphatase activity. 115,119 The silicon in the core of POSS is believed to bind calcium ions and trigger the deposition of hydroxyapatite (HAp).…”

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confidence: 99%

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Thermoplastic polyurethane/POSS nanohybrids: Synthesis, morphology, and biological properties

Ozimek,

Malarz,

Mrozek‐Wilczkiewicz

et al. 2024

J Biomed Mater Res

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Recent studies show good osteoinductive properties of polyurethanes modified with polyhedral oligomeric silsesquioxanes (POSS). In this work, three types of POSS; propanediolisobutyl‐POSS (PHI‐POSS), disilanolisobutyl‐POSS (DSI‐POSS), and octahydroxybutyl‐POSS (OCTA‐POSS) were chemically incorporated into linear polyurethane based on an aliphatic isocyanate, hexamethylene diisocyanate (HDI), to obtain new nanohybrid PU‐POSS materials. The full conversion of POSS was confirmed by Fourier transform infrared spectroscopy (FTIR‐ATR) spectra of the model reactions with pure HDI. The materials obtained were investigated by FTIR, SEM‐EDS, and DSC. The DSC studies showed the thermoplasticity of the obtained materials and apparently good recovery. 30‐day immersion in SBF (simulated body fluid) revealed an increase in the rate of deposition of hydroxyapatite (HAp) for the highest POSS loadings, resulting in thick layers of hydroxyapatite (~60–40 μm), and the Ca/P ratio 1.67 (even 1.785). The structure and properties of the inorganic layer depend on the type of POSS, the number of hard segments, and those containing POSS, which can be tailored by changing the HDI/poly(tetramethylene glycol) (PTMG) ratio. Furthermore, the obtained composites revealed good biocompatibility, as confirmed by cytotoxicity tests conducted on two cell lines; normal human dermal fibroblasts (NHDF) and primary human osteoblasts (HOB). Adherent cells seeded on the tested materials showed viability even after a 48‐h incubation. After this time, the population of viable, and proliferating cells exceeded 90%. Bioimaging studies have shown the fibroblast and osteoblast cells were well attached to the surface of the tested materials.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Thermoplastic polyurethane/POSS nanohybrids: Synthesis, morphology, and biological properties

Ozimek,

Malarz,

Mrozek‐Wilczkiewicz

et al. 2024

J Biomed Mater Res

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“…Hydrogels with physical structures and chemical compositions that have ability to promote cell proliferation and differentiation are highly attractive in bone regeneration [39,40]. In addition, hydrogels have a hydrophilic surface, which is conducive to more cell attachment [41], and connected porous network structure suitable for drug delivery and substance exchange [42]. In the near future, therefore, there's no doubt hydrogels will act as a powerful tool for the clinical treatment of bone defects.…”

Section: Introductionmentioning

confidence: 99%

A multifunctional composite hydrogel that sequentially modulates the process of bone healing and guides the repair of bone defects

Lu,

Wang,

Zou

et al. 2024

Biomed. Mater.

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Calcium carbonate (CaCO3), which exhibits excellent biocompatibility and bioactivity, is a well-established bone filling material for bone defects. Here, we synthesized CaCO3 microspheres (CMs) to use as an intelligent carrier to load bone morphogenetic protein-2 (BMP-2). Subsequently, drug-loaded CMs and catalase (CAT) were added to methacrylated gelatin (GelMA) hydrogels to prepare a composite hydrogel for differential release of the drugs. CAT inside hydrogels was released with a fast rate to eliminate H2O2 and generate oxygen. Constant BMP-2 release from CMs induced rapid osteogenesis. Results in vitro indicated that the composite hydrogels efficiently reduced the level of intracellular reactive oxygen species (ROS), preventing cells from being injured by oxidative stress, promoting cell survival and proliferation, and enhancing osteogenesis. Furthermore, animal experiments demonstrated that the composite hydrogels were able to inhibit the inflammatory response, regulate macrophage polarization, and facilitate the healing of bone defects. These findings indicate that a multi-pronged strategy is greatly expected to promote the bone healing by modulating pathological microenvironments.

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In Vitro Models and Molecular Markers for Assessing Nano-Based Systems Inflammatory Potential

Lima

Antunes

Costa

et al. 2023

Interdisciplinary Biotechnological Advances

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Calcitonin-loaded octamaleimic acid–silsesquioxane nanoparticles in hydrogel scaffold support osteoinductivity in bone regeneration

Cited by 10 publications

References 60 publications

Thermoplastic polyurethane/POSS nanohybrids: Synthesis, morphology, and biological properties

Thermoplastic polyurethane/POSS nanohybrids: Synthesis, morphology, and biological properties

A multifunctional composite hydrogel that sequentially modulates the process of bone healing and guides the repair of bone defects

In Vitro Models and Molecular Markers for Assessing Nano-Based Systems Inflammatory Potential

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