Calcitonin Levels Do Not Decrease with Weaning in Chronic Alcoholism

Vantyghem, Marie-Christine; Danel, Thierry; Marcelli-Tourvieille, S.; Moriau, J; Leclerc, L; Cardot-Bauters, C.; Docao, C.; Carnaille, B.; Wémeau, Jean-Louis; d’Herbomez, Michèle

doi:10.1089/thy.2006.0216

Cited by 23 publications

(14 citation statements)

References 42 publications

(48 reference statements)

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“…Few women in our study (<4%) consumed 14 or more drinks per week, which by many standards would be considered moderate alcohol consumption at an average or two drinks per day, therefore we could not examine whether alcohol effects varied according to menopause or HIV status. Possible explanations of a beneficial effect of light or moderate alcohol consumption on BMD in women include an increase in calcitonin, which inhibits bone resorption, 45 an increase in estrogen level, 46,47 and lower bone remodeling with decreased levels of serum osteocalcin and N and C terminal telopeptides of type I collagen. 48,49 …”

Section: Discussionmentioning

confidence: 99%

Association of Regional Body Composition With Bone Mineral Density in HIV-Infected and HIV-Uninfected Women

Sharma

Tian

Yin

et al. 2012

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Objective To understand how regional body composition affects bone mineral density (BMD) in HIV-infected and uninfected women. Methods Dual energy X-ray absorptiometry was used to measure regional lean and fat mass and BMD at lumbar spine (LS), total hip (TH), and femoral neck (FN) in 318 HIV-infected and 122 HIV-uninfected Women's Interagency HIV Study participants at baseline and 2 and 5 years later. Total lean and fat mass were measured using bioimpedance analysis. Multivariate marginal linear regression models assessed the association of HIV status and body composition on BMD change. Results Compared to HIV-uninfected women, HIV-infected women were older (44 vs. 37 yrs), more likely to be HCV-infected (32% vs. 14%), and post-menopausal (26% vs. 3%), and had lower baseline total fat mass, trunk fat and leg fat. In multivariate models, increased total lean mass was independently associated with increased BMD at LS, TH and FN and total fat mass was associated with increased BMD at TH and FN (all p<0.05). When total fat was replaced in multivariate models with trunk fat and leg fat, increased trunk fat (and not leg fat) was associated with increased TH and FN BMD (p<0.001). Conclusions Total fat and lean mass are strong, independent predictors of TH and FN BMD, and lean mass was associated with greater LS BMD. Regardless of HIV status, greater trunk fat (and not leg fat) was associated with increased TH and FN BMD, suggesting that weight bearing fat may be a more important predictor of BMD in the hip.

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Section: Discussionmentioning

confidence: 99%

Association of Regional Body Composition With Bone Mineral Density in HIV-Infected and HIV-Uninfected Women

Sharma

Tian

Yin

et al. 2012

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…Moderate alcohol consumption may increase calcitonin, which is a thyroid hormone that inhibits bone resorption [112]. This may explain the beneficial effects of moderate alcohol consumption sometimes observed in women [110] (Fig.…”

Section: Calcitoninmentioning

confidence: 99%

Alcohol and bone: review of dose effects and mechanisms

et al. 2011

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Alcohol is widely consumed across the world. It is consumed in both social and cultural settings. Until recently, two types of alcohol consumption were recognized: heavy chronic alcohol consumption or light consumption. Today, there is a new pattern of consumption among teenagers and young adults namely: binge drinking. Heavy alcohol consumption is detrimental to many organs and tissues, including bones, and is known to induce secondary osteoporosis. Some studies, however, have reported benefits from light alcohol consumption on bone parameters. To date, little is known regarding the effects of binge drinking on bone health. Here, we review the effects of three different means of alcohol consumption: light, heavy, and binge drinking. We also review the detailed literature on the different mechanisms by which alcohol intake may decrease bone mass and strength. The effects of alcohol on bone are thought to be both direct and indirect. The decrease in bone mass and strength following alcohol consumption is mainly due to a bone remodeling imbalance, with a predominant decrease in bone formation. Recent studies, however, have reported new mechanisms by which alcohol may act on bone remodeling, including osteocyte apoptosis, oxidative stress, and Wnt signalling pathway modulation. The roles of reduced total fat mass, increased lipid content in bone marrow, and a hypoleptinemia are also discussed.

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“…A difference in calcitonin level between smokers and non‐smokers could not be confirmed41, 42. However, there were no women among the 35 smokers with CCH who had surgery, supporting the notion that sex is a major factor in CCH12, 13.…”

Section: Discussionmentioning

confidence: 92%