These results suggest that metabolic results improve with both methods, but were significantly better with IIT versus IPII, though with more frequent side effects.
This study suggests that sirolimus, at plasma-drug concentrations usually targeted in clinical practice, (1) increases basal and stimulated insulin levels in vivo and insulin content in vitro regardless of culture duration; (2) is able to reduce apoptosis. These findings may partly underlie the improved results of islet transplantation.
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