Calcitonin Gene-Related Peptide during Sweating in Young Healthy Women

Spetz, Anna-Clara; Ellefsen, Katrine; Theodorsson, Elvar; Lassvik, C.; Hammar, Mats

doi:10.1159/000086208

Cited by 6 publications

(5 citation statements)

References 53 publications

(46 reference statements)

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“…QSART volume is dependent on the number of sudomotor fibers responding to iontophoretic simulation, the number of efferent fibers activated in the reflex arc, and the amount of sweat produced by individual glands in response to stimulation (Schlereth et al, 2005). Variability in sweat gland output may be because of humoral factors (Spetz et al, 2005) or differences in local skin temperature (Ogawa and Sugenoya, 1993) and could contribute to the lability of the sudomotor response. Variability in sweat gland output may be because of humoral factors (Spetz et al, 2005) or differences in local skin temperature (Ogawa and Sugenoya, 1993) and could contribute to the lability of the sudomotor response.…”

Section: Discussionmentioning

confidence: 99%

“…Assuming that electrode position was nearly identical between successive tests (i.e., the same population of sudomotor fibers was activated), individual sweat gland output may have influenced sweat volumes between tests (Schlereth et al, 2005). For example, Spetz et al (2005) reported hormonal variations in sweat responses in women. For example, Spetz et al (2005) reported hormonal variations in sweat responses in women.…”

Section: Discussionmentioning

confidence: 99%

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Test–Retest Reliability of Quantitative Sudomotor Axon Reflex Testing

Berger

Kimpinski²

2013

Journal of Clinical Neurophysiology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Test–Retest Reliability of Quantitative Sudomotor Axon Reflex Testing

Berger

Kimpinski²

2013

Journal of Clinical Neurophysiology

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“…The endothelium may play a particularly important role. Pronounced alterations in plasma calcitonin gene-related peptide, a potent and partly endothelium-dependent vasodilator, are observed among women with hot flashes15 and acutely during hot flashes15 but not during other sweating 16. However, the role of the vasculature in hot flashes has received limited attention.…”

Section: Discussionmentioning

confidence: 99%

“…Hypoestrogenic states are associated with impaired endothelial functioning,12, 13 and estrogen use among younger postmenopausal women has been associated with fewer calcified plaques in the coronary arteries 14. Further, potent vasodilators such as calcitonin gene-related peptide are released during hot flashes but not during exercise or sweating 15, 16. Finally, risk factors for hot flashes are also cardiovascular risk factors, including obesity and smoking 1…”

mentioning

confidence: 99%

Hot Flashes and Subclinical Cardiovascular Disease

et al. 2008

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Background-Although evidence suggests adverse vascular changes among women with hot flashes, it is unknown whether hot flashes are associated with subclinical cardiovascular disease. The aim of this study was to examine relations between menopausal hot flashes and indices of subclinical cardiovascular disease. We hypothesized that women with hot flashes would show reduced flow-mediated dilation and greater coronary artery and aortic calcification compared with women without hot flashes. Methods and Results-The Study of Women's Health Across the Nation Heart Study (2001 to 2003) is an ancillary study to the Study of Women's Health Across the Nation, a community-based cohort study. Participants were 492 women (35% black, 65% white) 45 to 58 years of age who were free of clinical cardiovascular disease and had a uterus and at least 1 ovary. Measures included a brachial artery ultrasound to assess flow-mediated dilation, electron beam tomography to assess coronary artery and aortic calcification, reported hot flashes (any/none, previous 2 weeks), and a blood sample for measurement of estradiol concentrations. Cross-sectional associations were evaluated with linear regression and partial proportional odds models. Hot flashes were associated with significantly lower flow-mediated dilation (␤ϭϪ1.01; SE, 0.41; Pϭ0.01) and greater coronary artery (odds ratio, 1.48; 95% confidence interval, 1.04 to 2.12) and aortic (odds ratio, 1.55; 95% confidence interval, 1.10 to 2.19) calcification in age-and race-adjusted models. Significant associations between hot flashes and flow-mediated dilation (␤ϭϪ0.97; SE, 0.44; Pϭ0.03) and aortic calcification (odds ratio, 1.63; 95% confidence interval, 1.07 to 2.49) remained in models adjusted for cardiovascular disease risk factors and estradiol. Conclusions-Women

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“…In resting humans, the blood concentration of αCGRP shows a large inter-individual variability (14.0–132.5 pg·mL −1 ) [ 19 ], but it seems to be very constant intra-individually [ 20 ]. Although baseline blood αCGRP seems to be unaffected by training [ 21 ], several independent works found that this neuropeptide transiently increases in the blood in response to exercise [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. However, fifteen years after the description of this phenomenon [ 21 ], the physiological significance of αCGRP release during exercise is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Acute Increase in Blood αCGRP at Maximal Exercise and Its Association to Cardiorespiratory Fitness, Carbohydrate Oxidation and Work Performed: An Exploratory Study in Young Men

Aracil-Marco

Sarabia²,

Pastor³

et al. 2021

Biology

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This study aimed to explore if the acute variations in plasma concentration of α-calcitonin gene-related peptide (αCGRP) induced by a single maximal exercise bout may be associated to cardiorespiratory fitness and carbohydrate oxidation in humans. Twelve young adult Caucasian men (24.3 ± 0.9 years-old; 179.2 ± 1.9 cm of height; 23.9 ± 0.6 kg·m−2 body mass index) performed a graded exercise test. A venous catheter was placed before testing, and blood samples were taken at baseline, maximal effort and recovery. αCGRP was measured in plasma using a commercial double-sandwich enzyme-linked-immunoassay. A two-way repeated measurements ANOVA was used to compare the values obtained at baseline, maximal effort and recovery. In the whole sample, αCGRP increased at maximal effort and its concentration correlated directly, albeit non-significantly, with the muscle mass normalised VO2, VCO2, carbohydrate oxidation and relative power. Two thirds of the participants showed an increase in αCGRP concentration at maximal effort. Post hoc analysis showed that in these individuals, the muscle mass normalised VO2, VCO2, carbohydrate oxidation rate and relative power were higher than in the participants lacking this molecular response. Therefore, our data suggest that (a) a majority of young men respond to exercise with an increase in blood αCGRP concentration; and (b) individuals exhibiting this response also show a higher cardiorespiratory fitness, carbohydrate oxidation and work performed. These findings suggest that this neuropeptide could act as an exerkine with potential effects on physical performance.

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Calcitonin Gene-Related Peptide during Sweating in Young Healthy Women

Cited by 6 publications

References 53 publications

Test–Retest Reliability of Quantitative Sudomotor Axon Reflex Testing

Test–Retest Reliability of Quantitative Sudomotor Axon Reflex Testing

Hot Flashes and Subclinical Cardiovascular Disease

Acute Increase in Blood αCGRP at Maximal Exercise and Its Association to Cardiorespiratory Fitness, Carbohydrate Oxidation and Work Performed: An Exploratory Study in Young Men

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