Test–Retest Reliability of Quantitative Sudomotor Axon Reflex Testing

Berger, Michael; Kimpinski, Kurt

doi:10.1097/wnp.0b013e3182873254

Cited by 27 publications

(20 citation statements)

References 15 publications

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“…35 One recent study demonstrated that test-retest reliability can be moderate with a large standard error of measurement. 36 The results further suggested a limited utility of QSART for longitudinal and interventional studies. It is unclear where QSART stands in the diagnosis of SFN, but, similar to QST, it should not be used as the only investigation modality to confirm SFN.…”

Section: Resultsmentioning

confidence: 99%

“…In patients with SFN the assessments of somatic (skin biopsy and QST) and peripheral autonomic small fiber function (QSART) are complementary and, when combined, improve the sensitivity for diagnosis of SFN . One recent study demonstrated that test–retest reliability can be moderate with a large standard error of measurement . The results further suggested a limited utility of QSART for longitudinal and interventional studies.…”

Section: Resultsmentioning

confidence: 99%

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Small fiber neuropathy: Getting bigger!

2016

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Etiological and clinical heterogeneity of small fiber neuropathy (SFN) precludes a unifying approach and necessitates reliance on recognizable clinical syndromes. Symptoms of SFN arise from dysfunction in nociception, temperature, and autonomic modalities. This review focuses on SFN involving nociception and temperature, examining epidemiology, etiology, clinical presentation, diagnosis, pathophysiology, and management. Prevalence of SFN is 52.95 per 100,000 population, and diabetes and idiopathic are the most common etiologies. Dysesthesia, allodynia, pain, burning, and coldness sensations frequently present in a length-dependent pattern. Additional autonomic features in gastrointestinal, urinary, or cardiovascular systems are frequent but poorly objectified. SFN is diagnosed by intraepidermal nerve fiber density and quantitative sensory and autonomic tests in combination with normal nerve conduction. Pathophysiological understanding centers on sodium channel dysfunction, and genetic forms are beginning to be understood. Treatment is directed at the underlying etiology supported by symptomatic treatment using antidepressants and anticonvulsants. Little is known about long-term outcomes, and systematic cohort studies are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Small fiber neuropathy: Getting bigger!

2016

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“…Thus, other autonomic testing methodologies should be explored for sexual dysfunction characterization in MS patients. Other autonomic tests, such as acetylcholine skin tests (Berger and Kimpinski, 2013;Kandeel et al, 2001), still hold the promise for diagnosing various types of autonomic neuropathy that contributes to erectile dysfunction in MS.…”

Section: Discussionmentioning

confidence: 99%

Autonomic dysfunction in multiple sclerosis

Racosta

Kimpinski

Morrow

et al. 2015

Autonomic Neuroscience

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“…Quantitative sudomotor axon reflex test is an alternative diagnostic tool but test and pretest reliability have been found to be moderate. 4 Finally, microneurography is an invasive test, which by placing recording microelectrodes within nerve fascicles, enables multiple small fibers to be recorded simultaneously. 5 The diagnosis of the underlying cause of subacute monophasic small fiber neuropathy depends on the identification of likely underlying causes.…”

Section: Sectionmentioning

confidence: 99%