Calciphylaxis with facial involvement

Mathur, Rashmi V.; Shortland, J. R.; Nahas, A. Meguid El

doi:10.1093/ndt/16.11.2256

Cited by 15 publications

(29 citation statements)

References 10 publications

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“…Multiple risk factors have been identified and divided into modifiable and non-modifiable categories (Table 1) [2,6,7,25,26]. The complex pathogenesis of the disease is thought to involve multiple proinflammatory cytokines including tumour necrosis factor α (TNF-α), IL-1 and IL-6, and oxidative stress due to not only kidney failure but also coexisting diseases such as arterial hypertension, hypercholesterolaemia, obesity or type 2 diabetes [2,3,6,7,26]. All the disorders listed above are known to be characterized by the depletion of antioxidants, for example glutathione [2].…”

Section: Kalcyfilaksja -Wapniejąca Arteriolopatia Mocznicowamentioning

confidence: 99%

Skin changes in chronic kidney disease

Przepiórka-Kosińska¹,

Chyl-Surdacka²,

Bartosińska³

et al. 2017

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Chronic kidney disease causes skin changes which may sometimes be the first sign of kidney failure. Specific skin changes include acquired perforating dermatosis, porphyria cutanea tarda, pseudoporphyria, calcinosis and nephrogenic systemic fibrosis. The majority of patients present with cutaneous manifestations which are classified as nonspecific, including xerosis, pruritus, pigmentation disturbances, nail plate abnormalities, uraemic frost and gynaecomastia. Treatment improving kidney function (dialysis therapy or kidney transplantation) also leads to the resolution of skin lesions. STRESZCZENIEPrzewlekła choroba nerek powoduje zmiany skórne, które niejednokrotnie mogą być pierwszym objawem niewydolności nerek. Do swoistych zmian skórnych należą: nabyta perforująca dermatoza, porfiria skórna późna, pseudoporfiria, zwapnienia oraz uogólnione nerkopochodne włóknienie. Zmiany zaliczane do objawów nieswoistych, takie jak suchość skóry, świąd skóry, zmiany jej zabarwienia, nieprawidłowości dotyczące płytek paznokciowych, szron mocznicowy oraz ginekomastia, są spotykane u większości pacjentów. Leczenie powodujące poprawę wydolności nerek (dializoterapia lub przeszczepienie nerki) prowadzi jednocześnie do złagodzenia lub ustąpienia objawów skórnych.

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Section: Kalcyfilaksja -Wapniejąca Arteriolopatia Mocznicowamentioning

confidence: 99%

Skin changes in chronic kidney disease

Przepiórka-Kosińska¹,

Chyl-Surdacka²,

Bartosińska³

et al. 2017

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“…Recognising these risk factors together with vilgilance associated with new lesion formation represents the best chance for early diagnosis. [6] Box 1 -Risk factors for Calciphylaxis [3,7] Female …”

Section: Clinical Presentation and Diagnosismentioning

confidence: 99%

“…Where Calciphylaxis is suspected in the absence of renal disease other co-morbidities (e.g. primary hyperparathyroidism, liver disease, and inflammatory arthritis) can lead to a higher index for suspicion [7,10,18].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Calciphylaxis – A case study in a patient with Maori heritage

Kingi

Grech

Lam

et al. 2016

Journal of Tissue Viability

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This case history describes a rare complaint -Calciphylaxis, seen in a New Zealand Maori patient undergoing renal dialysis. This condition causes non-healing tissue ulceration, typically with sepsis and is associated with a very high mortality rate. The need for vigilance among health professionals is highlighted, including the risk factors that may faciliate an early diagnosis; together with the value associated with a multi-disciplinary team approach to management.

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“…The treatment for calciphylaxis is mainly supportive. 16,17 Good responses with symptomatic improvement have been reported with total or partial parathyroidectomy with reimplantation. Regardless, calciphylaxis carries a poor prognosis, with mortality rates reported as high as 60% to 80%.…”

mentioning

confidence: 99%