Sonography in the Identification of Calciphylaxis of the Breast

Bukhman, Rita; Scheri, Randall P.; Selim, M. Angélica; Baker, Jay A.

doi:10.7863/jum.2010.29.1.129

Cited by 14 publications

(8 citation statements)

References 16 publications

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“…14 Ultrasonographic changes include tissue edema and shadowing foci suggestive of extensive macrocalcification 14. Definitive diagnosis requires a biopsy.…”

Section: Vascular Diseasementioning

confidence: 99%

Breast manifestations of systemic diseases

Dilaveri

Bride

Sandhu

et al. 2012

IJWH

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Although much emphasis has been placed on the primary presentations of breast cancer, little focus has been placed on how systemic illnesses may affect the breast. In this article, we discuss systemic illnesses that can manifest in the breast. We summarize the clinical features, imaging, histopathology, and treatment recommendations for endocrine, vascular, systemic inflammatory, infectious, and hematologic diseases, as well as for the extramammary malignancies that can present in the breast. Despite the rarity of these manifestations of systemic disease, knowledge of these conditions is critical to the appropriate evaluation and treatment of patients presenting with breast symptoms.

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“…14 Ultrasonographic changes include tissue edema and shadowing foci suggestive of extensive macrocalcification 14. Definitive diagnosis requires a biopsy.…”

Section: Vascular Diseasementioning

confidence: 99%

Breast manifestations of systemic diseases

Dilaveri

Bride

Sandhu

et al. 2012

IJWH

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“…Despite significant pain and discomfort associated with the procedure, several studies have championed the use of mammography in aiding diagnosis (51,52). A noninvasive and less painful alternative for identifying deeper breast lesions is sonography, on which diffuse parenchymal edema, skin thickening, and numerous echogenic foci with posterior acoustic shadowing suggestive of large calcifications may be visualized (53). Recently, nuclear bone scans have shown promise as a diagnostic tool for calciphylaxis (35,54–57).…”

Section: Workupmentioning

confidence: 99%

Calciphylaxis

Peng

2011

Dermatologic Therapy

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Calciphylaxis is a disease in which metastatic calcification affects small- and medium-sized vessels resulting in significant dermatologic manifestations. Lesions typically occur over areas of high fat content and progress to black leathery eschars. Calciphylaxis is associated with intense pain and markedly increased risk of infection, often leading to sepsis requiring hospitalization. Diagnosis is made by clinical history and skin biopsy. Management of calciphylaxis is interdisciplinary, emphasizing factors such as primary prevention, proper wound care, pain control, and hormone and mineral balance. Although calciphylaxis carries a high mortality rate, symptomatic treatment has shown promise as a method for controlling disease progression.

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“…Also, due to patchy calcification patterns, histology can be inconclusive 5. As regards the breast, we believe that sonography6 and mammography are sufficient for diagnosis in these patients. Therefore, depending on individual circumstances, we encourage critically reassessing the necessity of biopsies in these patients.…”

Section: Discussionmentioning

confidence: 90%

Breast pain in a patient on dialysis: a rare manifestation of calcific uraemic arteriolopathy

Buscher¹,

Gabriëls²,

Barth

et al. 2015

BMJ Case Reports

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A 63-year-old woman presented with progredient bilateral breast pain. Her medical history included rheumatoid arthritis, AA amyloidosis and end-stage renal disease treated by peritoneal dialysis. Inflamed skin alterations of the breast and laboratory values suggested mastitis non-puerpuralis but antibiotics did not resolve the symptoms. Sonography and mammography showed severe vessel calcification suggesting calcific uraemic arteriolopathy (calciphylaxis) as a rare complication of chronic kidney disease. Treatment included intensified haemodialysis, thiosulfate application, analgaesia and wound management leading to significant improvement, however, without complete remission.

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Sonography in the Identification of Calciphylaxis of the Breast

Cited by 14 publications

References 16 publications

Breast manifestations of systemic diseases

Breast manifestations of systemic diseases

Calciphylaxis

Breast pain in a patient on dialysis: a rare manifestation of calcific uraemic arteriolopathy

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