Calciphylaxis Associated With Rheumatoid Arthritis: Communication of Another Case

Ortiz, Alberto; Roverano, Susana; Gallo, Jesica; Henares, Eduardo; Eletti, M; Paira, Sergio

doi:10.1016/j.reumae.2015.07.005

Cited by 3 publications

(2 citation statements)

References 12 publications

(13 reference statements)

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“…Other morbidities among the included studies were warfarin induced (7.54 %) [23,24,25 1). Similarly, other remaining etiological conditions were; primary hyperparathyroidism [35], malignancy [36], glucocorticoid [37], stage IV non-Hodgkin lymphoma [38], chronic kidney disease [39], acenocumarol use [40], weight loss and hypotension [41], rheumatoid arthritis and hypotension [42], diuretic therapy [43], diabetes mellitus type-II [44], psoriasis [45], rheumatologic disease [46], multiple myeloma and rheumatoid arthritis [47], alcoholic hepatitis [48], covid-19 [49], liver transplant [50], SLE and antiphospholipid antibody syndrome (APS) [51], recombinant human parathyroid hormone therapy (PTH) [52], autoimmune disease [53], coumarin necrosis and vasculitis [54], neuroendocrine tumor (NET) [55], rheumatoid arthritis [56]. In addition, majority of the wounds of NUC were seen on legs (n = 20, 37.73 %), thighs (n = 16, 30.18), calves (n = 7, 13.20 %), breast (n = 4, 7.54 %) as well as buttocks (n = 4, 7.54 %), respectively.…”

Section: Fig 1 An Overview Of the Approach For Doing A Literature Searchmentioning

confidence: 99%

Nonuremiccalciphylaxis - A Systematic Review

Albalawi

Dighriri

Alsharif

et al. 2021

JPRI

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Background: Calciphylaxis, also known as calcific uremic arteriolopathy, is a well-described condition in renal transplant and end-stage kidney disease (ESKD) patients; however, little is known about calciphylaxis induced by nonuremic causes. This systematic study aimed to determine the causes, prognosis of nonuremic calciphylaxis, clinical features and laboratory abnormalities. Patients and methods:A comprehensive review of the literature for nonuremic calciphylaxis case reports and case series published between 2016 and 2021 was performed. Cases included satisfied the criteria for a histological diagnosis of nonuremic calciphylaxis in the absence of ESKD, renal transplantation, or acute kidney injury requiring renal replacement therapy. Results: The authors identified 53 cases of nonuremic calciphylaxis (83.14 % women, Caucasian 13.33 %, aged 25 to 83 years). The most prevalent documented associations were of patients having multiple conditions 18 (33.33 %), warfarin-induced (7.4 %), calcium and Vitamin D supplementation (3.7 %), primary hyperparathyroidism (3.7 %), liver disease (3.7 %), Acenocumarol use (3.7 %), Systematic lupus erythematosus (3.7 %), alcoholic cirrhosis (3.7 %), respectively. Conclusion:When investigating skin lesions in patients with sensitive conditions, calciphylaxis must often be addressed in the absence of ESKD or renal transplantation. Obese women with various underlying illnesses such as alcohol intake, smoking, diabetes, liver disease, and so on are more likely to develop nonuremic calciphylaxis (NUC).Calciphylaxis is linked with high mortality; however, sodium thiosulfate (ST) has made clear progress in terms of treatment, yet there are still areas that need to be addressed to describe the effectiveness of ST.

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Section: Fig 1 An Overview Of the Approach For Doing A Literature Searchmentioning

confidence: 99%

Nonuremiccalciphylaxis - A Systematic Review

Albalawi

Dighriri

Alsharif

et al. 2021

JPRI

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“…There are multiple contributing factors in calciphylaxis like calcium and phosphorus metabolism disorders and the probable deficiency of vascular calcification inhibitors such as fetuin-A. Although calciphylaxis predominantly occurs in patients with end-stage renal disease, it has been reported in patients without renal failure but hyperphosphatemia, rheumatoid arthritis (a probable comorbidity) and prednisolone consumption (a possible risk factor, but the potential confounding by indication or other drugs should be considered) 1–3…”

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Calciphylaxis in an adolescent without renal failure

2022

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Warfarin-induced calciphylaxis-related skin ulceration in patients with end-stage renal disease: case report and literature review

Vallini,

Andreini,

Sibilia

et al. 2024

J Wound Care

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Calciphylaxis is a rare but highly disabling disease, occurring both in chronic kidney disease (CKD) with renal replacement therapy (RRT) and in normal renal function. Given the frequent coexistence of atrial fibrillation (AF) and CKD, anticoagulation is often required. Warfarin, as a promoter of vascular calcification, is frequently reported as a triggering factor of calciphylaxis. Here, we present the case of a 71-year old male patient with a history of AF and a previous ischaemic stroke, on RRT for three years and warfarin therapy. The patient presented with two painful necrotic skin ulcers over the right leg and a skin biopsy confirmed calciphylaxis. After discontinuation of warfarin, the lesions completely healed with sodium thiosulfate intravenous infusion and local wound treatment. A literature search was performed up to 1 September 2022 through PubMed. The following terms were searched in different combinations: ‘calciphylaxis’; ‘VKA’ [vitamin K antagonist]; ‘warfarin’; ‘haemodialysis’; ‘end-stage renal disease’; and ‘ulcer’. In our opinion, in patients requiring anticoagulant therapy, the introduction or continuation of vitamin K antagonists (VKAs) should be carefully balanced when calciphylaxis develops, and other options, such as enoxaparin or apixaban, should be considered. Clinical decisions for patients requiring haemodialysis and requiring anticoagulant therapy should take into account the possible risk of warfarin-induced calciphylaxis. Further studies are needed to clarify the safety, tolerability profile and outcomes of each currently available treatment in this patient population.

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Calciphylaxis Associated With Rheumatoid Arthritis: Communication of Another Case

Cited by 3 publications

References 12 publications

Nonuremiccalciphylaxis - A Systematic Review

Nonuremiccalciphylaxis - A Systematic Review

Calciphylaxis in an adolescent without renal failure

Warfarin-induced calciphylaxis-related skin ulceration in patients with end-stage renal disease: case report and literature review

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