Calcio-Herbal Medicine Divya-Swasari-Vati Ameliorates SARS-CoV-2 Spike Protein-Induced Pathological Features and Inflammation in Humanized Zebrafish Model by Moderating IL-6 and TNF-α Cytokines

Balkrishna, Acharya; Verma, Sudeep; Solleti, Siva Kumar; Khandrika, Lakshmipathi; Varshney, Anurag

doi:10.2147/jir.s286199

Cited by 15 publications

(21 citation statements)

References 66 publications

(74 reference statements)

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“…were demonstrated by various investigations in hosts or experimental models of pathologies with state of immunosuppression. [5,[41][42][43][44][45][46] Published evidences support the significant efficacy of the herbal preparations in pathological conditions involving inappropriate (insufficient or hyper-active) immune responses. Although modulations of physiological parameters have been shown after the intake of herbal drugs/preparations in healthy individuals, most of the evidence came from the investigations on pathological conditions.…”

Section: Concept Of Herbal Immunity Boostersmentioning

confidence: 98%

“…[49] A similar upsurge in the responsiveness of immune cells was also reported in human patients/animal models of pathological conditions. [5,42,44,45] e relatively augmented responsiveness suggests that herbal preparations may provide attentiveness to the immune cells which may take a short time or low stimulus to achieve an optimal immune response. is partially mimics the immunity-boosting abilities of natural infection or vaccination, although pieces of evidence are very less in number in this line.…”

Section: Concept Of Herbal Immunity Boostersmentioning

confidence: 99%

“…[50,51] e effectiveness of herbal compounds or preparations in reinstating immune responsiveness in many pathological conditions is well established. [38,[40][41][42][43][44][45][46]55] e beneficial role of herbal preparations in suppressed state of immunity; and the frequent occurrence of low immunity state in current age due to various lifestyle factors exist simultaneously. As per the probability game theory, then it becomes more apparent to have a support of herbal preparation favoring the optimal immune response when needed.…”

Section: Concept Of Herbal Immunity Boostersmentioning

confidence: 99%

“…[65,66] Apart from this, various approaches have been implemented for appraising the potential of these phytochemicals or formulations in the therapeutic management of COVID-19. [2,3,9,33,44,66] e previously known benefits of these herbal drugs or formulations provide an advantage for their use in the management of symptoms. [3,5,9,33] e in silico predictive tools also offered rapid screenings of pure phytochemicals or constituents present in the formulations.…”

Section: Immunity Boosters Against Covid-19: Are They For Real?mentioning

confidence: 99%

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Immunity boosters in COVID-19: Reality or myth?

et al. 2022

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COVID-19 pandemic has posed an unprecedented threat to human beings. The emergence of pathogens always had been a threat as the designing and verification of treatment strategies and vaccines take time. In such a scenario, the use of strategies, formulations, or chemicals to improve immunity can provide protection, at least partially. The use of some traditional or folk medicinal preparations and other supplements derived from plants are among the most common agents used for keeping immunity tidy and tough. They are used by many with the belief that being herbal in origin these agents are safe. These formulations/preparations are regarded as “Immunity Boosters.” Revolving information and advertisements in bulk and the strategies of “the attention economy” also propagate this belief. The term “Immunity Booster” is a misnomer for these agents and is scientifically not approved. However, the benefits of these herbal formulations cannot be denied. Few of these herbal formulations have benefits in preventive and therapeutic management infections including those of SARS-CoV-2. Due to lifestyle, diet habits, deficiencies and neuropsychological stress, the immunity of a large fraction of the population is not optimal. Uncertainty and fear prevalent in the time of pandemic also negatively affect the immunity threshold. Many phytochemicals have been proven to aid in maintaining the threshold of immune response to an optimal level in subjects with compromised states of immunity. The immunomodulatory potential of these traditional herbal formulations also offers advantages when used along with standard operating procedures in COVID-19. Proposed formulations and their components also have disadvantageous effects and must be used under supervision with scientific methods. Excessive use of these agents may not only affect the organ and tissues deleteriously, but it can also invite immunopathology. Experimental verification of benefits being offered by these herbal agents will aid in their rightful exploitation in the therapy of human ailments including COVID-19.

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Section: Concept Of Herbal Immunity Boostersmentioning

confidence: 98%

Section: Concept Of Herbal Immunity Boostersmentioning

confidence: 99%

Section: Concept Of Herbal Immunity Boostersmentioning

confidence: 99%

Section: Immunity Boosters Against Covid-19: Are They For Real?mentioning

confidence: 99%

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Immunity boosters in COVID-19: Reality or myth?

et al. 2022

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“…DSV is also used to control COVID-19-associated respiratory symptoms [159]. DSV exerts its pharmacological activity against SARS-CoV-2-induced inflammation in a humanized zebrafish model through the amelioration of the inflammation induced by SARS-CoV-2 spike protein demonstrated by the blockage of pro-inflammatory IL-6 and TNFα cytokine surge [163]. Indeed, high-performance liquid chromatography-diode array detection (HPLC-DAD) has been recently used to estimate the levels of several phytochemicals, including but not restricted to phenolics (gallic acid, protocatechuic acid, ellagic acid, coumarin, cinnamic acid, glycyrrhizin, eugenol, 6-gingerol, piperine, methyl gallate, and glabridin), in five batches of DSV [159].…”

Section: Traditional Herbal Medicine Rich In Phenolics Protecting Against Sars-cov-2-induced Lung Damagementioning

confidence: 99%

Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risks

et al. 2021

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The risks related to the COVID-19 are multi-faceted including but by far not restricted to the following: direct health risks by poorly understood effects of COVID-19 infection, overloaded capacities of healthcare units, restricted and slowed down care of patients with non-communicable disorders such as cancer, neurologic and cardiovascular pathologies, among others; social risks—restricted and broken social contacts, isolation, professional disruption, explosion of aggression in the society, violence in the familial environment; mental risks—loneliness, helplessness, defenceless, depressions; and economic risks—slowed down industrial productivity, broken delivery chains, unemployment, bankrupted SMEs, inflation, decreased capacity of the state to perform socially important programs and to support socio-economically weak subgroups in the population. Directly or indirectly, the above listed risks will get reflected in a healthcare occupation and workload which is a tremendous long-term challenge for the healthcare capacity and robustness. The article does not pretend to provide solutions for all kind of health risks. However, it aims to present the scientific evidence of great clinical utility for primary, secondary, and tertiary care to protect affected individuals in a cost-effective manner. To this end, due to pronounced antimicrobial, antioxidant, anti-inflammatory, and antiviral properties, naturally occurring plant substances are capable to protect affected individuals against COVID-19-associated life-threatening complications such as lung damage. Furthermore, they can be highly effective, if being applied to secondary and tertiary care of noncommunicable diseases under pandemic condition. Thus, the stratification of patients evaluating specific health conditions such as sleep quality, periodontitis, smoking, chronic inflammation and diseases, metabolic disorders and obesity, vascular dysfunction, and cancers would enable effective managemenet of COVID-19-associated complications in primary, secondary, and tertiary care in the context of predictive, preventive, and personalized medicine (3PM).

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Development and validation of a rapid high‐performance thin‐layer chromatographic method for quantification of gallic acid, cinnamic acid, piperine, eugenol, and glycyrrhizin in Divya‐Swasari‐Vati, an ayurvedic medicine for respiratory ailments

Balkrishna

Sharma

Joshi

et al. 2021

J of Separation Science

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Divya‐Swasari‐Vati is a calcium containing polyherbal ayurvedic medicine prescribed for the lung‐related ailments observed in the current pandemic of Severe Acute Respiratory Syndrome Coronavirus 2 infections. The formulation is a unique quintessential blend of nine herbs cited in Ayurvedic texts for chronic cough and lung infection. Analytical standardization of herbal medicines is the pressing need of the hour to ascertain the quality compliance. This persuaded us to develop a simple, rapid, and selective high‐performance thin‐layer chromatographic method for Divya‐Swasari‐Vati quality standardization. The developed method was validated for the quantification of marker components, gallic acid, cinnamic acid, piperine, eugenol and glycyrrhizin, against reference standards in five different batches of Divya‐Swasari‐Vati. The analytes were identified by visualization at 254 nm, and by matching their retention factor with authentic standards. The developed method was validated as per the guidelines recommended by the International Council for Harmonization for parameters like, linearity, limit of detection, limit of quantification, accuracy, and precision. Therefore, the developed novel high‐performance thin‐layer chromatographic process could be employed for rapid standardization of Divya‐Swasari‐Vati and other related herbal formulation, which would aid in quality manufacturing and product development.

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Calcio-Herbal Medicine Divya-Swasari-Vati Ameliorates SARS-CoV-2 Spike Protein-Induced Pathological Features and Inflammation in Humanized Zebrafish Model by Moderating IL-6 and TNF-α Cytokines

Cited by 15 publications

References 66 publications

Immunity boosters in COVID-19: Reality or myth?

Immunity boosters in COVID-19: Reality or myth?

Targeting phytoprotection in the COVID-19-induced lung damage and associated systemic effects—the evidence-based 3PM proposition to mitigate individual risks

Development and validation of a rapid high‐performance thin‐layer chromatographic method for quantification of gallic acid, cinnamic acid, piperine, eugenol, and glycyrrhizin in Divya‐Swasari‐Vati, an ayurvedic medicine for respiratory ailments

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