Calcifying panniculitis in a child after renal transplantation

Nogueira, Paulo César Koch; Giuliani, Carina; Rey, N; Saïd, MH; Cochat, P

doi:10.1093/ndt/12.1.216

Cited by 17 publications

(14 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, by its high calcium content, nadroparin might induce precipitation in a local environment which is already characterized by a high calcium-phosphate product. Indeed, calcified subcutaneous nodules have been described previously after subcutaneous administration of calcium heparin in patients with chronic renal insufficiency [4, 5]. Renal insufficiency does not appear to be a prerequisite however, since calcinosis cutis has also been reported at the site of subcutaneous calcium heparin injection in a patient without chronic renal failure or hyperphosphatemia [6].…”

Section: Discussionmentioning

confidence: 99%

Nadroparin-Induced Calcinosis cutis in Renal Transplant Recipients

Haren¹,

Ruiter²,

Hilbrands

2001

Nephron

View full text Add to dashboard Cite

Low-molecular-weight heparins are routinely used to prevent deep venous thrombosis following renal transplantation in our department. We report 2 patients who developed tender erythematous subcutaneous nodules with induration, ulceration and necrosis at the site of subcutaneous administration of nadroparin. Both patients were renal transplant recipients with impaired graft function and high serum calcium-phosphate products. The diagnosis calcinosis cutis was confirmed by technetium-99m bone scan and by histological examination of biopsies. Both patients showed spontaneous recovery several weeks after discontinuation of nadroparin. Patients with chronic renal failure and hyperphosphatemia may be predisposed to develop calcinosis cutis. In addition, the role of the calcium content of nadroparin is discussed.

show abstract

Section: Discussionmentioning

confidence: 99%

Nadroparin-Induced Calcinosis cutis in Renal Transplant Recipients

Haren¹,

Ruiter²,

Hilbrands

2001

Nephron

View full text Add to dashboard Cite

show abstract

“…Only one report confirmed the diagnosis of calciphylaxis with skin biopsy [11]. Most of these cases had elevated calcium-phosphorus product [11,12,13,14,15,16] and elevated PTH levels [11,12,13,14,15]. One report had low calcium-phosphorus at presentation with pulmonary calcification [17]; however, in that patient the renal failure and pulmonary calcification resolved after 1 year of presentation.…”

Section: Discussionmentioning

confidence: 99%

Calciphylaxis in pediatric end-stage renal disease

et al. 2005

View full text Add to dashboard Cite

Calciphylaxis is a rare, but life-threatening complication of end-stage renal disease (ESRD) that has been reported mostly in adult patients. The exact etiology is unknown, but the disease is commonly associated with a high calcium-phosphorus product and elevated levels of parathyroid hormone (PTH). We herein review the published reports on calciphylaxis in ESRD patients less than 18 years old and report the case of a patient with severe calciphylaxis who presented with lower extremity pain, muscle tenderness and difficulty in walking. The serum PTH was low, and the calcium-phosphorus product was normal. The diagnosis of calciphylaxis was confirmed by a muscle biopsy. Treatment with low calcium peritoneal dialysate and substitution of calcium-based phosphorus binders with sevelamer (Renagel) was unsuccessful. The patient's clinical condition progressed to extensive soft tissue calcification and ulcerating skin lesions. Nine months after the onset of symptoms, the patient died of cardiopulmonary arrest.

show abstract

“…Four main types have been defined as: 1) lobular panniculitis without vasculitis, 2) lobular panniculitis with vasculitis 3) septal panniculitis without vasculitis, 4) septal panniculitis with vasculitis [3] . Although calcifying panniculitis has been known since the 1980s, it is seen in the classification as a special topic [4][5][6][7][8][9][10] . That type of panniculitis has been generally reported in humans with renal failure and has primarily involved anticoagulantlike heparin injection sites [4,9] .…”

Section: Introductionmentioning

confidence: 99%

“…Although calcifying panniculitis has been known since the 1980s, it is seen in the classification as a special topic [4][5][6][7][8][9][10] . That type of panniculitis has been generally reported in humans with renal failure and has primarily involved anticoagulantlike heparin injection sites [4,9] . The place of calcifying panniculitis has not been conclusive despite being known as a sub-class of lobular panniculitis without vasculitis [11] .…”

Section: Introductionmentioning

confidence: 99%