Calcifying Epithelial Odontogenic Tumor: Case Report With Immunohistochemical and Ultrastructural Study and Review of the Literature

Lin, Jeffrey; Bianchi, M; Popnikolov, Nikolay K.; Abaza, Nabil A.

doi:10.1016/j.joms.2012.06.171

Cited by 20 publications

(12 citation statements)

References 43 publications

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“…A frequent radiographic finding in these tumors has been the presence of calcifying structures of varying sizes inside the lesions. Besides this, the cases reported in the literature have mostly been painless, of a slow evolution, and in an intraosseous area [5] [12]. Supporting the literature, the present study reports the case of Pindborg tumor, located premolar region of the mandible and showing the presence of calcifying structures in the radiographic exam.…”

Section: Discussionsupporting

confidence: 73%

The Calcifying Epithelial Odontogenic Tumor (Pindborg Tumor): A Case Report

Akay¹,

Tetik²,

Zeytinoğlu³

2014

OALib

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Calcifying Epithelial Odontogenic Tumor (CEOT) is a rare benign odontogenic tumor that was first described by Pindborg in 1955. It accounts for less than 1% of all odontogenic neoplasms. This lesion is a locally aggressive benign odontogenic neoplasm arising from epithelial tissue. The radiographic appearance is characterized by uni-or multilocular radiolucent areas with radiopaque masses of varying sizes; there is a frequent association with an unerupted tooth. Most CEOT are intraosseous lesions which are most common in the mandible, with most of these occurring in the molar and premolar regions of the mandible. Malignant transformation and metastasis is rare. The aim of the current report was to describe the clinical radiological and histopathological findings in a case of mandibular CEOT. | Volume 1 | e1036 hard nodule on the right mandibular premolar region.

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Section: Discussionsupporting

confidence: 73%

The Calcifying Epithelial Odontogenic Tumor (Pindborg Tumor): A Case Report

Akay¹,

Tetik²,

Zeytinoğlu³

2014

OALib

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“…The round shaped eosinophilic amyloid material will stain positive for Congo red and will appear as an apple-green birefringence under a polarized microscope. [ 2 5 12 14 ] All these features did exist in the reported case. Due to the similarity of cellular pattern with various lesions, immunohistochemistry shall be performed to differentiate CEOT from other benign odontogenic tumor (esp.…”

Section: Discussionmentioning

confidence: 59%

“…[ 5 ] Although CEOT is a benign neoplasm, its biologic behavior is variable, ranging from very mild to moderately invasive behaviour. [ 5 10 14 ] However, in most cases, there is little information on tumor duration and hence the true growth rate of the tumor is questionable. [ 2 11 ]…”

Section: Discussionmentioning

confidence: 99%

Intraosseous calcifying epithelial odontogenic (Pindborg) tumor: A rare entity

Vijayvargiya

2015

J Oral Maxillofac Pathol

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Calcifying epithelial odontogenic tumor (CEOT) is a locally aggressive, rare benign odontogenic neoplasm that accounts for <1% of all odontogenic tumors. It was first described by a Dutch pathologist Jens Jorgen Pindborg in 1955. It is most often located in the posterior mandible. The tumor usually appears between the second and sixth decade of life and has no gender predilection. It is slow-growing neoplasm with a recurrence rate of 10–15% and with rare malignant transformation. Early diagnosis is essential to avoid oro-maxillofacial deformation and destruction. CEOT is rarely reported in India. We, herewith present a rare case of CEOT with unusual features associated with an impacted right third molar in the posterior mandible of 35 years male, with an emphasis on clinical, radiographic, histopathology and immunohistochemical features.

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“…KCOT have been documented to be EGFR-positive in 85–100% cases (60 cases total) [39, 50–52]. Additionally, a recent case report showed strong EGFR staining in a calcifying epithelial odontogenic tumor [53]. …”

Section: Epidermal Growth Factor Receptor (Egfr)mentioning

confidence: 99%

Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis

Amm

MacDougall

2016

Curr Oral Health Rep

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Several molecular pathways have been shown to play critical roles in the pathogenesis of odontogenic tumors. These neoplasms arise from the epithelial or mesenchymal cells of the dental apparatus in the jaw or oral mucosa. Next generation genomic sequencing has identified gene mutations or single nucleotide polymorphisms associated with many of these tumors. In this review, we focus on two of the most common odontogenic tumor subtypes: ameloblastoma and keratocystic odontogenic tumors. We highlight gene expression and protein immunohistological findings and known genetic alterations in the hedgehog, BRAF/Ras/MAPK, epidermal growth factor receptor, Wnt and Akt signaling pathways relevant to these tumors. These various pathways are explored to potentially target odontogenic tumors cells and prevent growth and recurrence of disease. Through an understanding of these signaling pathways and their crosstalk, molecular diagnostics may emerge as well as the ability to exploit identified molecular differences to develop novel molecular therapeutics for the treatment of odontogenic tumors.

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Calcifying Epithelial Odontogenic Tumor: Case Report With Immunohistochemical and Ultrastructural Study and Review of the Literature

Cited by 20 publications

References 43 publications

The Calcifying Epithelial Odontogenic Tumor (Pindborg Tumor): A Case Report

The Calcifying Epithelial Odontogenic Tumor (Pindborg Tumor): A Case Report

Intraosseous calcifying epithelial odontogenic (Pindborg) tumor: A rare entity

Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis

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