Calcifying Epithelial Odontogenic (Pindborg) Tumor of the Mandible With Clear Cell Component Treated by Conservative Surgery: Report of a Case

Germanier, Yves; Bornstein, Michael M.; Stauffer, Edouard; Buser, Daniel

doi:10.1016/j.joms.2005.05.298

Cited by 17 publications

(22 citation statements)

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“…Many studies have previously reported this staining characteristic of the amyloid-like material in CEOTs (Franklin et al 1981;El-Labban et al 1983;Asano et al 1990;Takata et al 1993;Aviel-Ronen et al 2000;Germanier et al 2005;Patino et al 2005). Despite the consistency of the positive Congo red reaction, the nature of the amyloid-like substance in CEOT is one of the most controversial topics.…”

Section: Discussionmentioning

confidence: 98%

“…According to the latest review literature (Philipsen and Reichart 2000), there were only 181 cases of CEOTs occurring in the intraosseous (170 cases) and extraosseous (11 cases) locations. Subsequently, there have been a small number of CEOTs studied in English language publications (Kumamoto et al 2001;Cheng et al 2002;Anavi et al 2003;Crivelini et al 2003;Solomon et al 2003;Makos and Nikolaidou 2004;Germanier et al 2005;Patino et al 2005;Seim et al 2005;Bornstein et al 2006;Bridle et al 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, despite the small number of documented CEOTs, several variants of this tumor have been reported. These include the presence of clear cells (Philipsen and Reichart 2000;Anavi et al 2003;Germanier et al 2005), Langerhans cells (Asano et al 1990;Takata et al 1993), myoepithelial cells (Philipsen and Reichart 2000), bone and cementum-like components (Slootweg 1991) in CEOTs. There have also been reports of adenomatoid odontogenic tumors (AOTs) (Philipsen and Reichart 2000) or ameloblastoma (Seim et al 2005) in combination with CEOTs.…”

Section: Introductionmentioning

confidence: 99%

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Calcifying epithelial odontogenic tumor: an immunohistochemical case study

Poomsawat

Punyasingh

2007

J Mol Hist

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Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic tumor. A case of CEOT in a 25-year-old female is presented here. Histologically, the case showed sheets of polyhedral epithelial cells with deep eosinophilic cytoplasm and prominent nuclei. Nuclear pleomorphism and hyperchromatism were evident. Globules of amyloid-like material among the tumor cells were prominent. Also found was a small area demonstrating a cribriform pattern. Immunohistochemical studies with antibodies against basement membrane proteins (laminins 1 and 5, collagen type IV and fibronectin), pan-cytokeratins AE1/AE3, vimentin, S-100 protein and CD 1a were performed. Tumor cells expressed laminins 1 and 5, fibronectin, cytokeratins and vimentin. The amyloid-like material was not reactive to all antibodies examined. A number of dendritic cells among sheets of tumor cells were revealed with strong staining for S-100 protein and CD 1a. These dendritic cells are likely to be Langerhans cells. Hence, immunohistochemistry is a useful method to study the variant of CEOT.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Calcifying epithelial odontogenic tumor: an immunohistochemical case study

Poomsawat

Punyasingh

2007

J Mol Hist

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“…The tumour-free margins are confirmed histopathologically and require radical resection of affected jaw portion and any associated soft tissues with no less than 1 cm in every direction [17].…”

Section: Treatmentmentioning

confidence: 92%

Calcifying Epithelial Odontogenic Tumour: A Case Report

Maria

Sharma

Malik

2010

J. Maxillofac. Oral Surg.

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Calcifying epithelial odontogenic tumour (CEOT) presenting at an unusual site is rare. The characteristic cytologic findings in association with radiologic features can help the cytopathologist and the surgeon in rendering a firm preoperative diagnosis of Calcifying Epithelial Odontogenic Tumour even at atypical sites such as maxilla. The purpose of this article is to report an additional case of CEOT and discuss the radiologic appearance, histologic features, clinical behavior and surgical management.

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“…Through a MEDLINE search for CCCEOT in the English-language literature (1967–2011), 14 cases were found; 3,4,5,6,7,8,9,10,11,12,13,14,15,16 however, this unusual lesion still needs continual documentation in order to have more information regarding clinical, microscopic features or behavior, particularly, the potential origins of the clear tumor cells. Therefore, the aim of the current report was to describe the clinical, radiographic, and histological findings in a case of mandibular CCCEOT.…”

Section: Introductionmentioning

confidence: 99%