Calcified cartilage zone and its dimensional relationship to the articular cartilage in the human temporomandibular joint of elderly individuals

Flygare, Lennart; Klinge, Björn; Rohlin, Madeleine; Åkerman, Sigvard; Lanke, Jan

doi:10.3109/00016359309041164

Cited by 13 publications

(4 citation statements)

References 19 publications

(17 reference statements)

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“…This study confirmed that the hypertrophic cell layer of the mandibular condyle disappears in the course of aging, implying changes in the cartilage calcification and ossification processes [1,[19][20][21].…”

Section: Discussionsupporting

confidence: 71%

Changes in type I, II, and X collagen immunoreactivity of the mandibular condylar cartilage in a naturally aging rat model

et al. 1997

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Abstract:The effect of aging on type I, II, and X collagen in the mandibular condyle was histologically and immunohistochemically assessed in 1-, 4-, 9-, and 16-month-old rats. Hypertrophic chondrocytes, observed in the 4-month-old rat, were absent in the 9-month-old. In 9-and 16-month-old rats, a mineralizing front ran parallel to the surface of the condyle, and the calcified cartilag e was thicker than in the younger rats. Type I collagen was observed from the fibrous layer to the upper maturative cell layer in the 1-and 4-month-old rats. in the 9-month-old, the type I collagen-positive area extended to the whole cartilaginous region. In the 16-month-old, type I collagen took on an archlike configuration around the lacunae. Intense type II collagen reactivity in the maturative and hypertrophic cell layers of the 1-month-old'rat was only slightly changed in the 4-month-old. In the 9-month-old rat, immunoreaction was detected from the proliferative cell layer; this extended to the whole cartilage in the 16-monthold. Type X collagen was localized in the hypertrophic cell layer in the 1-month-old and had expanded over the maturative cell layer in the 4-month-old rat. It was detected beneath the proliferative cell layer in the 16-month-old. Type X collagen was always observed in the area immediately above the mineralizing front of the cartilage matrix. Thus, our study indicated that mandibular condylar cartilage becomes fibrocartilage-like tissue with advancing age and that type X collagen may play a pivotal role in the progression of the mineralized front.

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Section: Discussionsupporting

confidence: 71%

Changes in type I, II, and X collagen immunoreactivity of the mandibular condylar cartilage in a naturally aging rat model

et al. 1997

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“…Several investigators have measured the thickness of the human calcified cartilage layer in an effort to learn more about its role in joint dysfunction (Muller-Gerbl et al 1987a,b;Oettmeier e t a l . 1989;Flygare et al 1993;Sokoloff 1993). Currently, most of the descriptive data are from human specimens, although several studies involve dogs (Oettmeier et al 1992) or rabbits (Oegema e t a l .…”

Section: Introductionmentioning

confidence: 99%

Age‐related morphometry of equine calcified cartilage

Martinelli

Eurell

Les

et al. 2002

Equine Veterinary Journal

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Summary Although there are many studies in the equine literature focused on articular diseases and the aetiology of osteoarthritis, few have concentrated on normal articular structures and how they change with age. The objective of this investigation was to study the thickness and morphology of the calcified cartilage layerof the distal metacarpus over a range of ages. A parasagittal slab of bone was sectioned from the region of sesamoid contact on the medial condyle of the metacarpi from 34 horses. The slab of bone was preserved, dehydrated and embedded, undecalcified, in methylmethacrylate and then stained with toluidine blue. Six repeatable fields of interest from the distal aspect of each metacarpus were digitised and examined to determine the morphology of the calcified cartilage layer. The thickness of the calcified cartilage, range 88–426 μm, was estimated using a method of integration. The results indicate an age‐related influence on the thickness of the calcified cartilage layer, generally increased in older horses. While this finding is significant, perhaps more importantly a positional relationship was also identified, indicating that pressures endured by different regions within a joint may dictate morphological development of the tissues. This study has begun to lay the groundwork to determine whether the calcified layer of the hyaline cartilage could be involved in the development of osteoarthritis.

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“…The mandibular condylar cartilage plays an important role in the development and function of the TMJ. 3 Numerous cells have been observed in the layer overlying the calcified cartilage zone in the mandibular condyle of elderly individuals, 17 but the type of cells has not been properly identified at that age. This study used differential histological stains, which further permit to differentiate various types of cells in the studied tissue, as well as to observe various tissues in the studied area.…”

Section: Discussionmentioning

confidence: 99%

Architecture of the Mandibular Condylar Cartilage of Elderly Individuals: A Semiquantitative Light Microscopic Histological Study

Ramirez-Yañez¹,

Scott²

2019

The Journal of Contemporary Dental Practice

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Aim: This study aimed to categorize the constituent tissues of the mandibular condylar cartilage of elderly individuals. Materials and methods: Thirty-three mandibular condyles were collected from 20 human cadavers of individuals between 40 years and 103 years old. Samples were stained with Masson's trichrome and Herovici's stains and, examined under a light microscope. Results: All samples showed tissues that were categorized as fibrous and hyaline cartilage in the mandibular condylar cartilage. A thick fibrous cartilage layer was differentiated on the top of a thinner hyaline cartilage in all of the examined samples. Undifferentiated cells, as well as mature and hypertrophic chondroblasts, were observed in the layer identified as hyaline cartilage, even though they were not in an organized manner. Conclusion:The observations from this study confirm that both fibrocartilage and hyaline cartilage are still present in the mandibular condylar cartilage of elderly individuals. Clinical significance: The results from this study infer that the mandibular condylar cartilage could be still able to respond to stimulus in adults. In that context, the results of the present study set the basis for future studies aiming to elucidate the biological activity and the remodeling potential of the tissues at the mandibular condyle in adults.

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Calcified cartilage zone and its dimensional relationship to the articular cartilage in the human temporomandibular joint of elderly individuals

Cited by 13 publications

References 19 publications

Changes in type I, II, and X collagen immunoreactivity of the mandibular condylar cartilage in a naturally aging rat model

Changes in type I, II, and X collagen immunoreactivity of the mandibular condylar cartilage in a naturally aging rat model

Age‐related morphometry of equine calcified cartilage

Architecture of the Mandibular Condylar Cartilage of Elderly Individuals: A Semiquantitative Light Microscopic Histological Study

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