Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial

Meyer, Odile; Dawson‐Hughes, Bess; Sidelnikov, Eduard; Egli, Andreas; Grob, Daniel; Staehelin, Hannes B.; Theiler, G.; Kressig, Reto W.; Simmen, Hans‐Peter; Bischoff‐Ferrari, Heike A.

doi:10.1007/s00198-014-2949-1

Cited by 19 publications

(19 citation statements)

References 34 publications

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“…Similar results were observed for the 140 μg bolus (13). As far as clinical outcomes, calcidiol showed beneficial effect on muscle performance, lower extremity function and blood pressure (14). There are few data on the long-term skeletal effects of calcidiol and few studies have compared different therapeutic regimens in terms of effect on vitamin D status and bone metabolism.…”

supporting

confidence: 65%

Oral calcidiol is a good form of vitamin D supplementation

Biondi

Pepe

Biamonte

et al. 2017

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supporting

confidence: 65%

Oral calcidiol is a good form of vitamin D supplementation

Biondi

Pepe

Biamonte

et al. 2017

ccmbm

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“…Indeed, no data on falls are available during calcidiol supplementation, while a better muscular performance has been demonstrated [16,39]. We acknowledge that not having included fall assessment in the safety analysis is a limitation of our study.…”

Section: Discussionmentioning

confidence: 95%

“…Indeed, some randomized controlled trials have demonstrated increased muscle performance in postmenopausal women supplemented with calcidiol at usual doses with respect to cholecalciferol [16,39], although the risk of falling during calcidiol supplementation has not been assessed yet as a primary outcome. These properties make calcidiol a good alternative to cholecalciferol in the treatment of the widespread vitamin D deficiency and related musculoskeletal consequences (osteomalacia, falls, and fractures), and even the supplement of choice when specific conditions hamper the efficacy of parental vitamin D.…”

Section: Discussionmentioning

confidence: 99%

Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens

et al. 2017

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Summary Rationale: Calcidiol can be employed to correct vitamin D deficiency. Main results: Calcidiol administered at daily and weekly regimens over a period of 3 months was able to successfully raise 25-hydroxyvitamin D levels without altering other markers related to bone and mineral metabolism. Significance: Calcidiol supplementation is effective and safe. Introduction The correction of vitamin D status is necessary to maintain an optimal mineral and skeletal homeostasis. Despite cholecalciferol (vitamin D 3 ) is the most commonly used drug for vitamin D supplementation, the more hydrophilic compound calcidiol (25-hydroxyvitamin D 3 ) can be employed at daily, weekly, and monthly regimens to reach in the short term the target levels of serum 25-hydroxyvitamin D [25(OH)D]. In the administration of different doses of calcidiol pharmacokinetic study (ADDI-D study), the efficacy and safety of daily and weekly dosages of calcidiol were tested. Methods A total of 87 Caucasian, community-dwelling, postmenopausal women, aged 55 years or older, with vitamin D inadequacy (serum 25(OH)D levels <30 ng/ml, with mean 25(OH)D below 20 ng/ml, namely 16.5 ± 7.5 ng/ml) were randomized to receive three different dosages of calcidiol: 20 μg/day, 40 μg/day, and 125 μg/week for 3 months. The attained level of serum 25(OH)D was selected as primary endpoint to assess efficacy, while other parameters of mineral metabolism, (serum calcium, parathyroid hormone, phosphate, FGF23, urinary calcium, and markers of bone turnover) were assessed as secondary endpoints to establish safety. Results In all the three groups, serum 25(OH)D values significantly and promptly rose and plateaued above the 30 ng/ml threshold remaining within safety interval after 14 days of treatment, with similar efficacy for the similar daily and weekly dose regimens. The different dosages were also equally effective in controlling secondary hyperparathyroidism. No significant changes in calcium and phosphate metabolism and in bone turnover markers were observed for any of the treatments, confirming the safety of this compound. Conclusions The results of this study demonstrate the shortand mid-term efficacy and safety on core parameters of mineral metabolism of different daily or weekly dosages of calcidiol when used to treat vitamin D inadequacy or deficiency in postmenopausal women. Further studies are needed to assess falls as primary outcome of calcidiol supplementation.

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“…The included studies were published between 2000 and 2019. Studies were conducted in the USA , Thailand , China , Switzerland , Australia , Brazil , Japan , Netherland , Denmark , Turkey , Norway , UK , Belgium , Finland and Indonesia . None of the studies were of an international multicentre type.…”

Section: Resultsmentioning

confidence: 99%

“…The sample size of the included studies ranged from 20 to 30 531 . The duration of follow‐up ranged from 4 weeks to 60 months .…”

Section: Resultsmentioning

confidence: 99%

The effects of vitamin D supplementation on muscle strength and mobility in postmenopausal women: a systematic review and meta‐analysis of randomised controlled trials

Abshirini

Mozaffari

Kord‐Varkaneh

et al. 2019

J Human Nutrition Diet

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Background The results obtained from previous trials regarding the effects of vitamin D supplementation on muscle strength and mobility in postmenopausal women have been inconsistent. This systematic review and meta‐analysis of randomised controlled trials (RCTs) aimed to investigate the effect of vitamin D supplementation on muscle strength and mobility in postmenopausal women. Methods A comprehensive search on EMBASE, PubMed, MEDLINE and SCOPUS was performed to identify relevant articles published up to 28 March 2019. RCTs published in English measuring the effect of all forms and doses of vitamin D supplementation with or without calcium on muscle strength and mobility outcomes in postmenopausal women were included. Results In total, 29 eligible studies were included in the systematic review. The pooled findings using a random effects model showed that vitamin D supplementation insignificantly increased hand grip strength (HGS) as the measurement of muscle strength (MD = 0.656; 95% confidence interval = −0.037 to 1.350, P = 0.06). However, it did not affect timed‐up‐and‐go (TUG) as the measurement of mobility (MD = 0.118; 95% confidence interval = −0.655 to 0.892, P = 0.76). The subgroup analyses showed that vitamin D supplementation improved HGS with respect to dosages >1000 IU day−1 (P = 0.016), a treatment duration of 3 months (P ˂ 0.001) and subjects with baseline vitamin D <30 ng mL−1 (P = 0.033). Conclusions The present review demonstrates that vitamin D supplementation resulted in small but nonsignificant improvements in muscle strength compared to control in postmenopausal women. No significant effect was observed in mobility after vitamin D administration.

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Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial

Abstract: Calcifediol improved gait speed in early postmenopausal women compared with vitamin D3 and change in 25(OH)D level was moderately correlated with improvement in gait speed. A benefit on trunk sway could not be demonstrated.

Cited by 19 publications

References 34 publications

Oral calcidiol is a good form of vitamin D supplementation

Oral calcidiol is a good form of vitamin D supplementation

Correction of vitamin D status by calcidiol: pharmacokinetic profile, safety, and biochemical effects on bone and mineral metabolism of daily and weekly dosage regimens

The effects of vitamin D supplementation on muscle strength and mobility in postmenopausal women: a systematic review and meta‐analysis of randomised controlled trials

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