Calanus oil in the treatment of obesity-related low-grade inflammation, insulin resistance, and atherosclerosis

Gasmi, Amin; Mujawdiya, Pavan Kumar; Shanaida, Mariia; Ongenae, Adrien; Lysiuk, Roman; Doşa, Monica Daniela; Tsal, Oxana; Piscopo, Salva; Chirumbolo, Salvatore; Bjørklund, Geir

doi:10.1007/s00253-019-10293-4

Cited by 26 publications

(22 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For krill oil, the only meta-analysis of RPCTs performed to date showed similar results to fish oil (Ursoniu et al 2017). Regarding Calanus oil, the antioxidant, anticholesterolemic and anti-inflammatory roles reported for this oil at the preclinical level (Gasmi et al 2020) have only been recently tested in humans (Wasserfurth et al 2020). In this study, the consumption of Calanus oil in people who were exercising moderately contributed to losing weight in a similar way as eating a healthy diet.…”

Section: Health Benefits Of Epa and Dhasupporting

confidence: 52%

Omega-3 nutraceuticals, climate change and threats to the environment: The cases of Antarctic krill and Calanus finmarchicus

Prado-Cabrero

Nolan

2021

Ambio

View full text Add to dashboard Cite

The nutraceutical market for EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) is promoting fishing for Euphasia superba (Antarctic krill) in the Southern Ocean and Calanus finmarchicus in Norwegian waters. This industry argues that these species are underexploited, but they are essential in their ecosystems, and climate change is altering their geographical distribution. In this perspective, we advocate the cessation of fishing for these species to produce nutraceuticals with EPA and DHA. We argue that this is possible because, contrary to what this industry promotes, the benefits of these fatty acids only seem significant to specific population groups, and not for the general population. Next, we explain that this is desirable because there is evidence that these fisheries may interact with the impact of climate change. Greener sources of EPA and DHA are already available on the market, and their reasonable use would ease pressure on the Arctic and Antarctic ecosystems.

show abstract

Section: Health Benefits Of Epa and Dhasupporting

confidence: 52%

Omega-3 nutraceuticals, climate change and threats to the environment: The cases of Antarctic krill and Calanus finmarchicus

Prado-Cabrero

Nolan

2021

Ambio

View full text Add to dashboard Cite

show abstract

“…The safety of human consumption of wax ester rich oil from copepods ( Calanus finmarchicus ) was studied through clinical trials (randomized, double-blind, placebo-controlled), and long-term consumption (12 months) of 2 g/day did not show any negative effects on hematological and clinical chemistry parameters, including gastrointestinal-related effects [ 87 , 88 ]. Despite a large amount of wax ester, calanus oil has been suggested as a good source of the long-chain polyunsaturated fatty acids (PUFA), eicosapentaenoic acid, and docosahexaenoic acid for humans, and commercial products are available as dietary supplements [ 89 , 90 ].…”

Section: Resultsmentioning

confidence: 99%

Undesirables in Mesopelagic Species and Implications for Food and Feed Safety—Insights from Norwegian Fjords

Wiech

Silva

Meier

et al. 2020

Foods

View full text Add to dashboard Cite

The increase in the global population demands more biomass from the ocean as future food and feed, and the mesopelagic species might contribute significantly. In the present study, we evaluated the food and feed safety of six of the most abundant mesopelagic species in Norwegian fjords. Trace elements (i.e., arsenic, cadmium, mercury, and lead), organic pollutants (i.e., dioxins, furans, dioxin-like polychlorinated biphenyls, and polybrominated flame-retardants), and potentially problematic lipid compounds (i.e., wax esters and erucic acid) were analyzed and compared to existing food and feed maximum levels and intake recommendations. Furthermore, contaminant loads in processed mesopelagic biomass (protein, oil, and fish meal) was estimated using worst-case scenarios to identify possible food and feed safety issues. While most undesirables were low considering European food legislation, we identified a few potential food safety issues regarding high levels of fluoride in Northern krill, wax esters in glacier lanternfish, and long-chain monounsaturated fatty acids in silvery lightfish. Our estimates in processed biomass indicated high levels of undesirable trace elements in the protein fraction, frequently exceeding the maximum levels for feed ingredients. However, in fish meal, almost no exceedances were seen. In the oil fraction, dioxins and furans were above the maximum levels, given for food and feed ingredients. The present study is crucial to enable an evaluation of the value of these species; however, more data is needed before proceeding with large-scale harvesting of mesopelagic biomass.

show abstract

“…Because a combination of exercise and n-3 PUFA supplementation has shown some beneficial effects on health and fitness [16,18,19], we focused on a novel class of n-PUFA supplementation-Calanus Oil produced from the marine copepod Calanus finmarchicus [26]. Calanus oil contains a combination of fatty acids, fatty alcohols, and wax esters, and is possibly the best alternative to fish oil whose production cannot keep pace with demand from the growing market [27]. Although, higher doses of Calanus oil are likely to be needed to increase the omega-3 index (defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids) as a reflection of an adequate resource of n-3 PUFA, its bio-availability seems to be sufficient [13].…”

Section: Discussionmentioning

confidence: 99%

Effect of Calanus Oil Supplementation and 16 Week Exercise Program on Selected Fitness Parameters in Older Women

et al. 2020

View full text Add to dashboard Cite

We investigated changes in functional fitness after an exercise program in combination with Calanus oil supplementation, a novel source of bioactive lipids rich in wax esters with omega-3 polyunsaturated fatty acid (n-3 PUFA). Fifty-five healthy sedentary women aged 65–80 (mean age 70.9 ± 3.9 years, BMI 27.24 ± 3.9 kg m−2, VO2peak 19.46 ± 3.7 ml kg−1 min−1) were enrolled in the study. The participants were divided into two groups: exercise training plus Calanus Oil supplementation (n = 28) or exercise plus placebo (sunflower oil) supplementation (n = 27). The exercise intervention program was completed by 53 participants and contained functional circuit training (twice a week, 45 min plus 15 min of stretching and balance training) and Nordic walking (once a week, 60 min) for 16 weeks. Senior fitness test, exercise stress test on bicycle ergometer, hand-grip, and body composition were evaluated before and after the program. Our results show that functional fitness and body composition improved following the interventional exercise program, but for most of the parameters there was no synergic effect of supplementing n-3 PUFA-rich Calanus oil. In comparison to the placebo group, the group with Calanus supplementation experienced significantly higher improvement of functional strength of lower body which was evaluated by the chair stand test. Supplementation with Calanus may have a synergic effect with exercise on functional strength of the lower body in the elderly.

show abstract

Calanus oil in the treatment of obesity-related low-grade inflammation, insulin resistance, and atherosclerosis

Cited by 26 publications

References 101 publications

Omega-3 nutraceuticals, climate change and threats to the environment: The cases of Antarctic krill and Calanus finmarchicus

Omega-3 nutraceuticals, climate change and threats to the environment: The cases of Antarctic krill and Calanus finmarchicus

Undesirables in Mesopelagic Species and Implications for Food and Feed Safety—Insights from Norwegian Fjords

Effect of Calanus Oil Supplementation and 16 Week Exercise Program on Selected Fitness Parameters in Older Women

Contact Info

Product

Resources

About