Caffeoylquinic Acids and Some Biological Activities ofPluchea symphytifolia

Abstract

From the aerial parts of Pluchea symphytifolia, four known and two new caffeoylquinic acids, 1,3,4,5-tetra-O-caffeoylquinic acid and 1,3-di-O-[3,4,-bis-(3,4-dihydroxyphenyl)-cyclobutane-1,2-dicarbonyl]- 4,5-di-O-caffeoylquinic acid, and two flavonols were isolated and their structures elucidated by mass and NMR spectroscopy and by chemical degradation. The aqueous extract had weak antibacterial and weak antisecretory effects; the lipophilic extract showed a modest anthelmintic activity. The higher caffeoylated quinic acids participated in the antibacterial and anthelmintic effect of the extracts.

Isolation of green coffee chlorogenic acids using activated carbon

“…CGAs are phenolic compounds of interest as they present several biological and functional properties: antimicrobial, antiviral, anti-mycotoxigenic, anti-carcinogenic, antioxidant, chelating, and ultraviolet filter (Morishita and Ohnishi, 2001;Scholz et al, 1994;Suá rez-Quiroz et al, 2004, 2013a, 2013b. CGAs could be then used as multifunctional natural antioxidants in food, feed, pharmaceutical, cosmetics or nutraceutical industries.…”

Mass spectrometry of 3,5- and 4,5-dicaffeoylquinic acids and selected derivatives

“…Caffeoylquinic acids (CQAs) are plant-derived compounds isolated from a variety of sources 1 -3 and which possess a broad spectrum of pharmacological properties, including antioxidant, 2,4 hepatoprotectant, 3 antibacterial, 5 antihistiminic, 6 and other biological effects. Most important, however, is the anti-HIV activity shown by of a number of di-and triesters of quinic acid containing caffeic 7 -11 and other 12 -14 related acids.…”

Lipophilisation de composés phénoliques par voie enzymatique et propriétés antioxydantes des molécules lipophilisées

“…Ils se présentent soit sous forme libre, soit sous forme d'esters ou de diesters de l'acide quinique et constituent dans ce dernier cas un groupe de composés appelés acides chlorogéniques [32] parmi lesquels l'acide 5-caféoylquinique est le constituant majoritaire (figure 2). Ces composés, partiellement solubles dans l'eau, montrent de puissantes activités antioxydantes assorties de propriétés bactéricides [33,34]. Dans ce contexte, nous avons envisagé la possibilité de lipophiliser les acides chlorogéniques en vue d'obtenir de nouvelles biomolécules combinant des propriétés émulsifiantes, antioxydantes et antimicrobiennes [35,36].…”