Caffeine triggers behavioral and neurochemical alterations in adolescent rats

Ardais, Ana Paula; Borges, Mauricio; Rocha, Andréia Silva da; Sallaberry, Cássia; Cunha, Rodrigo A.; Porciúncula, Lisiane O.

doi:10.1016/j.neuroscience.2014.04.003

Cited by 62 publications

(48 citation statements)

References 75 publications

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“…Specifically, we observed alterations in c-fos mRNA expression following stress in the PVN, CeA, and NAc, as well as basal increases in Crf mRNA in the CeA. Previous studies demonstrate that acute caffeine administration activates the HPA axis (Nicholson, 1989; Patz et al, 2006), and has anxiogenic effects (Ardais et al, 2014; Nardi et al, 2009). Our findings extend this work by demonstrating that chronic caffeine consumption during adolescence produces alterations in HPA activity, stress reactivity and anxiety that persist into adulthood even after removal of caffeine.…”

Section: Discussionmentioning

confidence: 53%

“…Seven days after arrival, caffeine-consuming rats were given access to a single bottle containing caffeine in water (0.3 g/L) for 28 days based on previously published procedures (Ardais et al, 2014; O’Neill et al, 2015). Caffeine consumption procedures occurred continuously between P28-P55 in adolescent studies and P67-94 in adult studies.…”

Section: Methodsmentioning

confidence: 99%

“…Similarly, energy drink consumption in Australian young adult males correlates with self-reported anxiety (Trapp et al, 2014). Rats administered acute caffeine also display increased anxiety while consuming caffeine during adolescence (Ardais et al, 2014). Thus, there is substantial evidence suggesting that caffeine consumption can influence anxiety in both adolescent and adults, although no studies have examined the long-term effects of chronic adolescent caffeine consumption on anxiety-related behaviors.…”

Section: Introductionmentioning

confidence: 99%

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Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling

O’Neill

Newsom

Stafford

et al. 2016

Psychoneuroendocrinology

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Caffeine is a commonly used psychoactive substance and consumption by children and adolescents continues to rise. Here, we examine the lasting effects of adolescent caffeine consumption on anxiety-related behaviors and several neuroendocrine measures in adulthood. Adolescent male Sprague-Dawley rats consumed caffeine (0.3 g/L) for 28 consecutive days from postnatal day 28 (P28) to P55. Age-matched control rats consumed water. Behavioral testing for anxiety-related behavior began in adulthood (P62) 7 days after removal of caffeine. Adolescent caffeine consumption enhanced anxiety-related behavior in an open field, social interaction test, and elevated plus maze. Similar caffeine consumption in adult rats did not alter anxiety-related behavior after caffeine removal. Characterization of neuroendocrine measures was next assessed to determine whether the changes in anxiety were associated with modifications in the HPA axis. Blood plasma levels of corticosterone (CORT) were assessed throughout the caffeine consumption procedure in adolescent rats. Adolescent caffeine consumption elevated plasma CORT 24 h after initiation of caffeine consumption that normalized over the course of the 28-day consumption procedure. CORT levels were also elevated 24 h after caffeine removal and remained elevated for 7 days. Despite elevated basal CORT in adult rats that consumed caffeine during adolescence, the adrenocorticotropic hormone (ACTH) and CORT response to placement on an elevated pedestal (a mild stressor) was significantly blunted. Lastly, we assessed changes in basal and stress-induced c-fos and corticotropin-releasing factor (Crf) mRNA expression in brain tissue collected at 7 days withdrawal from adolescent caffeine. Adolescent caffeine consumption increased basal c-fos mRNA in the paraventricular nucleus of the hypothalamus. Adolescent caffeine consumption had no other effects on the basal or stress-induced c-fos mRNA changes. Caffeine consumption during adolescence increased basal Crf mRNA in the central nucleus of the amygdala, but no additional effects of stress or caffeine consumption were observed in other brain regions. Together these findings suggest that adolescent caffeine consumption may increase vulnerability to psychiatric disorders including anxiety-related disorders, and this vulnerability may result from dysregulation of the neuroendocrine stress response system.

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Section: Discussionmentioning

confidence: 53%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling

O’Neill

Newsom

Stafford

et al. 2016

Psychoneuroendocrinology

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“…High doses of caffeine, which is the nonselective adenosine receptor antagonist, induce fear in healthy people and trigger panic attacks in anxiety disorder patients. [124][125][126] Adenosine through A1 and A2A receptors exert anxiolytic effect through its facilitatory influence on release of GABA in the septum and hippocampus. 127 On treatment with caffeine, rats were more anxious in the elevated plus-maze test (X-maze) 128 and a free exploratory paradigm, 129 while an adenosine-1 receptor agonist had an anxiolytic effect in the X-maze.…”

mentioning

confidence: 99%

Untitled

2017

IJPSR

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“…[21] However, the present study did not show clear morphology of hippocampal pyramidal neurons probably due to higher caffeine doses might be associated with a decreased density of cortical A1R and hippocampal BDNF levels. [22] However, an extensive study will be carried out further to find the effect of caffeine with different dosage of caffeine.…”

Section: National Journal Of Physiology Pharmacy and Pharmacologymentioning

confidence: 99%

Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats

A¹,

Mohan²,

Kumaresan³

2017

Natl J Physiol Pharm Pharmacol

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Background: Stress and increase in free radicals levels are known to alter cognition, learning, memory, and emotional responses. There is a marked impairment of hippocampus-dependent memory and suppression of long-term potentiation in the CA1 region of the hippocampus during stress. Aim and Objective: The aim of this study is to evaluate the hypothesized neuroprotective effect of oral antioxidants and piracetam in chronic restraint stress-induced rats. Materials and Methods: Healthy Wistar rats were divided into 5 groups (n = 6) each. Control group received neither stress nor oral antioxidant. Stress group received chronic restraint stress for 6 h per day for 21 days. Three experimental groups were administered vitamin C (100 mg/kg), beta-carotene (7 mg/kg), and caffeine (8 mg/kg), respectively. Evaluation parameters were measurement of serum nerve growth factor (NGF) using ELISA method. The oxidative stress markers, glutathione peroxidase (GPx), glutathione reductase, and malondialdehyde were measured. Histological analysis of CA1 region of the hippocampus was done to evaluate the structural changes of pyramidal neurons. Results: Vitamin C caused statistically significant (P < 0.001) increase in serum NGF. The results revealed that vitamin C caused statistically significant (P < 0.05) increase in antioxidant enzymes GPx, glutathione reductase. Vitamin C caused increase in neuronal cell size and volume in CA1 pyramidal layer of hippocampus. Conclusion: The findings of study are suggestive of neuroprotection, offered by administration of vitamin C compared to other antioxidants against chronic restraint stress-induced rats. These naturally available dietary vitamins might serve as an adjuvant therapy to avoid progression of brain damage during stress.

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Caffeine triggers behavioral and neurochemical alterations in adolescent rats

Cited by 62 publications

References 75 publications

Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling

Adolescent caffeine consumption increases adulthood anxiety-related behavior and modifies neuroendocrine signaling

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Chronic administration of Vitamin C increases cognitive function in chronic stress induced rats

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