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doi:10.13040/ijpsr.0975-8232.8(2).411-21

Cited by 6 publications

(5 citation statements)

References 70 publications

(79 reference statements)

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“…All these findings strongly suggest that animals exhibiting the hippocampal neuronal excitotoxicity tend to suffer from abridged exploratory and anxiety-like behavior. Concomitant with the current findings, it is well documented in the literature that any perturbations in the glutamatergic neurotransmission like glutamate excitotoxicity further leads to the pathogenesis of anxiety-like disorders(Cortese & Phan, 2005;Kaur & Singh, 2017). Moreover, decreased serotonergic activity has also been associated with the anxiety and major depression disorder(Albert et al, 2014).…”

supporting

confidence: 81%

AMPA induced cognitive impairment in rats: Establishing the role of endoplasmic reticulum stress inhibitor, 4‐PBA

Bhardwaj

Sharma

et al. 2021

J of Neuroscience Research

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Glutamate excitotoxicity and endoplasmic reticulum (ER) recently have been found to be instrumental in the pathogenesis of various neurodegenerative diseases. However, the paucity of literature deciphering the inter-linkage among glutamate receptors, behavioral alterations, and ER demands thorough exploration. Reckoning the aforesaid concerns, a prospective study was outlined to delineate the influence of ER stress inhibition via 4-phenylbutyric acid (PBA) on α-amino-3-hydroxy-5-methyl-4isoxazole propionic acid (AMPA) excitotoxicity-induced behavioral aspects and possible ER stress-glutamate linkage. Male SD rats were randomly divided into four groups namely sham (surgical control+vehicle, group 1), AMPA-induced excitotoxic group 2 receive a single intra-hippocampal injection of 10 mM AMPA, group 3 received AMPA along with PBA (i.p, 100 mg/kg body weight) for 15 days, and group 4 received PBA alone. Behavioral analyses were performed prior to the sacrifice of animals and hippocampus was extracted thereafter for further analysis. AMPA-induced excitotoxicity exhibited significant impairment of locomotion as well as cognitive functions. The levels of neurotransmitters such as dopamine, homo vanillic acid (HVA), norepinephrine, and serotonin were reduced accompanied by reduced expression of GLUR1 and GLUR4 (glutamate receptor) as well as loss of neurons in different layers of hippocampus. ER stress markers were upregulated upon AMPA excitotoxicity.However, chemical chaperone PBA supplementation remarkably mitigated the behavioral alterations along with expression of glutamate and ER stress intermediates/ markers in AMPA excitotoxic animals. Therefore, the present exploration convincingly emphasizes the significance of ER stress and its inhibition via PBA in combating cognitive impairment as well as improving locomotion in excitotoxic animals.

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supporting

confidence: 81%

AMPA induced cognitive impairment in rats: Establishing the role of endoplasmic reticulum stress inhibitor, 4‐PBA

Bhardwaj

Sharma

et al. 2021

J of Neuroscience Research

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“…A student warrior with adolescence who is in the process of transitioning into adulthood and suddenly enters into a physically and mentally burdensome environment. This situation can be a stressor so that it risks causing stress that will affect the physical and psychological condition of student soldiers during military education ( 15 , 16 ).…”

Section: Discussionmentioning

confidence: 99%

Differences Interval Training and Continuous Training on Endorphin Level and Anxiety Degrees in SECABA Rindam III Siliwangi Student Soldiers with Moderate Anxiety

Marlina¹,

Purba²,

Pandia³

et al. 2023

Med Arch

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Background: Endorphin is a biological change in molecular physiology that is commonly connected with anxiety. An increase in the level of anxiety is caused by both an increase and a decrease in the number of endorphins that are present in the brain; however, up until this point, it has never been reported that there is a relationship between the level of anxiety and the influence of interval training. Objective: The purpose of this study was to analyze the effect of training interval on endorphin level and anxiety degrees of secaba student soldiers with moderate degrees of anxiety. Methods: The subject of the study was a student soldier of Secaba Rindam III Siliwangi with moderate anxiety. The subject of the study gets information about the objectives and procedures of the study. Subjects who are willing to participate in the study sign informed consent. The next step was that group 1 was given an interval training treatment 3 times a week for 12 weeks and group 2 was given continuous training treatment. Results: The results showed that there was a difference where interval training is better than continuous training against increasing endorphin levels (30.9111.733 vs. 39.6519.956; p=0.043). The degree of anxiety decreased significantly after being given interval training treatment (64.64±3.671 vs. 29.50±4.165; p=0.0001). Similarly, there was a significant difference (p=0.027; p<0.05) where the treatment in the interval training group was better than that of the continuous training group against a decrease in the degree of anxiety. Conclusion: Interval training can increase endorphin levels in Secaba Rindam III Siliwangi Student Soldiers with Moderate Anxiety and Interval Training can lower the Degree of Anxiety in Secaba Rindam III Siliwangi Student Soldiers with Moderate Anxiety.

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“…Several physiological factors may explain the findings from this study and highlight possible avenues for application and future research. High salt concentrations modulate salt taste receptor release of 5-HT and NE ( Roper and Chaudhari 2017 ), neurotransmitters altered in depression ( Dean and Keshavan 2017 ), and anxiety ( Kaur and Singh 2017 ). If salt taste alterations are indicative of neurotransmitter imbalance, taste tests may be utilized in progress monitoring or diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Biologically, there are common processes between salt taste and mental health that suggest possible mechanisms for the relationships. Neurotransmitters such as serotonin (5-HT) and norepinephrine (NE) are modifiable factors that can alter salt taste ( Heath et al 2006 ; Roper and Chaudhari 2017 ; Smith et al 2021 ) and mood ( Dean and Keshavan 2017 ; Kaur and Singh 2017 ). Therefore, there may be salt taste-associated changes to neurotransmitters, impacting mental health.…”

Section: Introductionmentioning

confidence: 99%

Liking of salt is associated with depression, anxiety, and stress

Ferraris,

Scarlett,

Bucher

et al. 2023

Chemical Senses

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Early research has shown variations in salt taste qualities in depression, anxiety, and stress. These studies evaluated changes to salt taste intensity and liking (pleasantness) of salt solutions but not of salty foods. Therefore, an Australian population survey (n = 424) was conducted where participants rated recalled intensity and liking of salt index foods and completed the Depression, Anxiety, and Stress Scale (DASS-21) to measure these states. Standard least squares regression (post hoc Tukey’s HSD) compared means between groups, and nominal logistic regression assessed differences in distributions between categories. Higher salt liking was found in participants with DASS-21 scores indicative of severe depression (68.3 vs. 60.0, p = 0.005) and severe anxiety (68.4 vs. 60.0, p = 0.001) in comparison to those with normal scores, in all models. Higher salt liking was found in participants with DASS-21 scores indicative of moderate stress (67.7 vs. 60.2, p = 0.009) in the unadjusted model only. Higher salt liking was found in females with DASS-21 scores indicative of anxiety and stress, and in males with indicative depression and anxiety. No relationships between salt taste intensity ratings and the mood states were found. Results indicate that liking salty foods is positively correlated with depression, anxiety, and stress scores. Further research on the relationships between salt liking and intake of salt and salty foods, and the biological mechanisms of these mood states are needed to direct the application of findings toward potential new risk assessment measures, dietary interventions, or therapeutics.

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Abstract: Anxiety is a persistent feeling of dread, apprehension and impending disaster, or tension and uneasiness. The reported prevalence rates of psychiatric morbidity in the Indian industrial population range from 14-

Cited by 6 publications

References 70 publications

AMPA induced cognitive impairment in rats: Establishing the role of endoplasmic reticulum stress inhibitor, 4‐PBA

AMPA induced cognitive impairment in rats: Establishing the role of endoplasmic reticulum stress inhibitor, 4‐PBA

Differences Interval Training and Continuous Training on Endorphin Level and Anxiety Degrees in SECABA Rindam III Siliwangi Student Soldiers with Moderate Anxiety

Liking of salt is associated with depression, anxiety, and stress

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