Caffeine reduces cerebral blood flow in patients recovering from an ischaemic stroke

Ragab, Suzanne; Lunt, M. J.; Birch, Alexander A.; Thomas, Peter; Jenkinson, Damian

doi:10.1093/ageing/afh091

Cited by 12 publications

(6 citation statements)

References 19 publications

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“…However, the rapid onset of headache provoked by HD in our patient implies significantly faster caffeine elimination that could be explained by rapid removal of caffeine by dialysis. It has been demonstrated that caffeine reduces CBF in normal individuals and in patients recovering from an acute ischemic stroke [8]. In our patient, the measured blood flow velocities using TCD were within normal range at the beginning and in the end of dialysis session, implying that there was no change in CBF during her dialysis treatment.…”

Section: Discussionsupporting

confidence: 47%

Caffeine-withdrawal headache induced by hemodialysis

Nikic

Zidverc-Trajković

Andrić³

et al. 2009

J Headache Pain

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Section: Discussionsupporting

confidence: 47%

Caffeine-withdrawal headache induced by hemodialysis

Nikic

Zidverc-Trajković

Andrić³

et al. 2009

J Headache Pain

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“…The CBF was reduced in widespread regions spanning primarily subcortical gray matter (thalamus, basal ganglia, hippocampus, and posterior cingulum) and isolated frontal, parietal, and occipital regions. Previous studies that have focused on the effects of caffeine on CBF have primarily used it in conjunction with a clinical cohort 29 or with a sensory stimulus 30 as part of the paradigm. It is thus difficult, from these preexisting studies, to ascertain direct effects of caffeine on the normal baseline neurophysiology.…”

Section: Resting Cerebral Blood Flowmentioning

confidence: 99%

The Effect of Black Tea and Caffeine on Regional Cerebral Blood Flow Measured with Arterial Spin Labeling

Vidyasagar

Greyling

Draijer

et al. 2013

J Cereb Blood Flow Metab

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Black tea consumption has been shown to improve peripheral vascular function. Its effect on brain vasculature is unknown, though tea contains small amounts of caffeine, a psychoactive substance known to influence cerebral blood flow (CBF). We investigated the effects on CBF due to the intake of tea components in 20 healthy men in a double-blinded, randomized, placebo-controlled study. On separate days, subjects received a single dose of 184 mg caffeine (equivalent to one strong espresso coffee), 2,820 mg black tea solids containing 184 mg caffeine (equivalent to 6 cups of tea), 2,820 mg decaffeinated black tea solids, or placebo. The CBF and cerebrovascular reactivity (CVR) to hypercapnia were measured with arterial spin labeled magnetic resonance imaging (MRI) before and 2 hours after administration. We found a significant global reduction with caffeine (20%) and tea (21%) in gray matter CBF, with no effect of decaffeinated tea, suggesting that only caffeine influences CBF acutely. Voxelwise analysis revealed the effect of caffeine to be regionally specific. None of the interventions had an effect on CVR. Additional research is required to conclude on the physiologic relevance of these findings and the chronic effects of caffeine and tea intake on CBF.

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“…This cerebral vasoconstriction is caused by caffeine‐induced blockade of adenosine receptors (Ragab et al. ; Addicott et al. ; Sasaki et al.…”

Section: Discussionmentioning

confidence: 99%

Acute impact of drinking coffee on the cerebral and systemic vasculature

2017

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Previous studies have suggested that the risk of ischemic stroke increases immediately after drinking coffee. Indeed, drinking coffee, that is, caffeine, acutely increases arterial stiffness as well as blood pressure and peripheral vascular resistance. On the other hand, it has been reported that arterial stiffening is associated with elevation in the pulsatility index (PI) of cerebral blood flow (CBF), which increases the risk of brain disease. However, the effect of drinking coffee on the PI of the CBF and its interaction with arterial stiffness remain unknown. Against this background, we hypothesized that an acute increase in arterial stiffness induced by drinking coffee augments cerebral pulsatile stress. To test this hypothesis, in 10 healthy young men we examined the effects of drinking coffee on the PI of middle cerebral artery blood velocity (MCAv) and brachial‐ankle pulse wave velocity (baPWV) as indices of cerebral pulsatile stress and arterial stiffness, respectively. Mean arterial blood pressure and baPWV were higher (P < 0.01 and P = 0.02), whereas mean MCAV and mean cerebrovascular conductance index were lower upon drinking coffee (P = 0.02 and P < 0.01) compared with a placebo (decaffeinated coffee). However, there was no difference in the PI of MCAv between drinking coffee and the placebo condition. These findings suggest that drinking coffee does not increase cerebral pulsatile stress acutely despite an elevation in arterial stiffness in the systemic circulation.

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Caffeine reduces cerebral blood flow in patients recovering from an ischaemic stroke

Abstract: Since caffeine is present in the diet of most patients recovering from an acute ischaemic stroke this effect may have adverse clinical consequences.

Cited by 12 publications

References 19 publications

Caffeine-withdrawal headache induced by hemodialysis

Caffeine-withdrawal headache induced by hemodialysis

The Effect of Black Tea and Caffeine on Regional Cerebral Blood Flow Measured with Arterial Spin Labeling

Acute impact of drinking coffee on the cerebral and systemic vasculature

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