Caffeine modifies blood glucose availability during prolonged low-intensity exercise in individuals with type-2 diabetes

Abstract

Objective: The study investigated the effect of supplementation with maltodextrin (CHO) alone or associated to caffeine during exercise in T2DM subjects. Methods: Pilot study, using Eight subjects with T2DM, aged 55±10 years, received CHO (1g/kg) or caffeine (1.5 mg/kg) alone or associated before exercise protocol. The exercise was executed at 40% heart rate (HR) reserve for 40 min, with 10-min recovery. Blood pressure (BP) and perceived exertion scale (Borg) were checked every 2 min. Blood glucose (BG) was checked every 10 min. For statistical analysis, ANOVA test was used and the value was considered statistically significant at p <0.05. Results: The results showed that BP and HR did not change significantly among all treatments. Caffeine promoted a significant reduction in BG of 75 mg/dL (65%, p <0.05) during 40 min of exercise protocol compared to all groups. Conclusion: Supplementation with 1.5 mg/kg of caffeine reduces BG concentration during prolonged exercise in T2DM patients.

Beneficial Impact of Semicarbazide-Sensitive Amine Oxidase Inhibition on the Potential Cytotoxicity of Creatine Supplementation in Type 2 Diabetes Mellitus

“…Da Silva et al have studied the influence of 1.5 mg/kg caffeine intake on blood glucose levels in T2DM individuals throughout the exercise. This dose showed to be efficient for glucose-intolerance management [ 88 ]. Olivieri and Tipton have shown that 0.1–10 mM caffeine can inhibit SSAO activity IC 50 = 0.8 ± 0.3 mM in bovine serum [ 79 ].…”

Dual A1 and A2A adenosine receptor antagonists, methoxy substituted 2-benzylidene-1-indanone, suppresses intestinal postprandial glucose and attenuates hyperglycaemia in fructose-streptozotocin diabetic rats

“…Epidemiological studies showed that drinking coffee has positive effects on both glucose tolerance and sensitivity to insulin, thus reducing the risk of T2D over long periods of consumption [ 14 , 15 ]. Another study indicated that caffeine induced a significant reduction in blood sugar (about 65%) in T2D individuals during prolonged low-intensity exercise [ 16 ]. In addition, caffeine has shown to stimulate the intestinal anion secretion signalling pathway [ 17 ], resulting in membrane depolarisation and reducing the transmembrane Na + force responsible for the Na-dependent uptake of glucose [ 18 ].…”