Caffeine microparticles for nasal administration obtained by spray drying

Sacchetti, C.; Artusi, Mariella; Santi, Patrizia; Colombo, Paolo

doi:10.1016/s0378-5173(02)00177-1

Cited by 35 publications

(20 citation statements)

References 7 publications

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“…These devices were constituted by a pump, a nasal adapter, and a solid formulation reservoir. 57 A smaller adapter for small animals was added to the nasal adapter for humans. The insufflators were loaded with 1 mg of RK-loaded microparticles (corresponding to about 150 :g of RK).…”

Section: In Vivo Rk Administration and Quantificationmentioning

confidence: 99%

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

Gavini

Rassu

Ferraro

et al. 2011

Journal of Pharmaceutical Sciences

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Section: In Vivo Rk Administration and Quantificationmentioning

confidence: 99%

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

Gavini

Rassu

Ferraro

et al. 2011

Journal of Pharmaceutical Sciences

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“…The TEM images further confirmed that endostatin-loaded nanoparticles with an average size less than 100 nm were successfully synthesized in agreement with the DLS average size measurement. The SEM micrograph also suggested that some of the smaller particles possibly agglomerate to form larger nanoparticles [34] ranging between 200 and 400 nm. However, it should be noted that SEM images of the nanoparticles are acquired in their dried solid state as opposed to TEM and DLS average size measurements where the nanoparticles were dispersed in liquid.…”

Section: Confirmation Of the Physicochemical Properties Andmentioning

confidence: 98%

Design and Characterization of Endostatin-Loaded Nanoparticles for In Vitro Antiangiogenesis in Squamous Cell Carcinoma

Adeyemi

Choonara

Kumar

et al. 2017

Journal of Nanomaterials

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The aim of this study is to effectively enhance antitumor activities of endostatin by preparing polymeric nanocarriers. NMR and FT-IR spectra confirmed the successful grafting of the CHT-g-PEI and CHT-g-PEI-PEG-NH 2 conjugates. SEM micrographs confirmed the shape of endostatin-loaded nanoparticles to be spherical while both TEM and zeta size results showed nanoparticle's average size to be 100.6 nm having a positively charged surface with zeta potential of 7.95 mV. The concentrations of CHT and TPP as well as the changing pH conditions account for the increased swelling pattern of endostatin-loaded nanoparticles and influenced endostatin release in vitro. PEI increased the overall amine protonation while PEG aggravated endostatin encapsulation and release. Nanoparticles swell and release endostatin at acidic tumor pH of 6.8 compared to physiological pH of 7.4. The native CHT-g-PEI-PEG-NH 2 conjugate showed high cytocompatibility above 80% cell viability across tested formulations. Endostatin-loaded nanoparticles showed a significant reduction in cell viability across tested formulations, with 5.32% cell death at 125 g/mL and 13.36% at 250 g/mL following 24 hours' incubation period. Interestingly, more than a fourfold (61.68%) increment in cytotoxicity was observed at nanoparticle concentration of 1000 g/mL. It was concluded that CHT-g-PEI-PEG-NH 2 is an effective cargo for endostatin delivery with antiangiogenic effect in squamous cell carcinoma.

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“…5 Thus, mucoadhesive microspheres have been developed to decrease the effect of mucociliary clearance. [6][7][8][9][10][11][12][13][14][15] The microparticles form a gel-like layer, which is cleared slowly from the nasal cavity, resulting in a prolonged residence time of the drug formulation. Mucoadhesive microspheres significantly increase the systemic absorption of conventional drugs as well as polypeptides across the nasal membrane without the use of absorption enhancing agents that have the potential for irritation or damage.…”

Section: Introductionmentioning

confidence: 99%

In vivo evaluation of alginate microspheres of carvedilol for nasal delivery

Patil¹,

Kaul

Babbar

et al. 2011

J Biomed Mater Res

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Mucoadhesive alginate microspheres of carvedilol (CRV) for nasal administration intended to avoid first pass metabolism and to improve bioavailability were prepared and evaluated. The microspheres were prepared by emulsification cross-linking method. Radiolabeling of CRV and its microspheres was performed by direct labeling with reduced technetium-99m ((99m) Tc). In vivo studies were performed on New Zealand white rabbits by administering the microspheres intranasally using monodose nasal insufflator. The radioactivity was measured in a well-type gamma scintillation counter. The noncompartmental pharmacokinetic analysis was performed. The pattern of deposition and clearance of the microspheres were evaluated using a radioactive tracer and the noninvasive technique of gamma scintigraphy. The clearance of alginate microsphere was compared with that of control lactose. The microspheres were nonaggregated, free flowing powders with spherical shape, and smooth surface. Pharmacokinetics study displayed an increase in area under the curve and hence in relative bioavailability when compared with intravenous administration of drug. The nasal bioavailability was 67.87% which indicates that nasal administration results in improved absorption of CRV. The results of gamma scintigraphy showed that the alginate microspheres had significantly reduced rates of clearance from the rabbit nasal cavity when compared with the control lactose.

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Caffeine microparticles for nasal administration obtained by spray drying

Cited by 35 publications

References 7 publications

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

Design and Characterization of Endostatin-Loaded Nanoparticles for In Vitro Antiangiogenesis in Squamous Cell Carcinoma

In vivo evaluation of alginate microspheres of carvedilol for nasal delivery

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