Caffeine: mechanism of action, genetics, and behavioral studies conducted in task simulators and the field

Carvey, Christina E.; Thompson, Lauren; Mahoney, Caroline R.; Lieberman, Harris R.

doi:10.1017/cbo9780511783005.009

Cited by 13 publications

(8 citation statements)

References 35 publications

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“…Caffeine (1,3,7 trimethylxanthine) is the most widely consumed psychoactive substance in the world (Barone and Roberts 1996 ). When consumed, it is absorbed and distributed throughout the body, including the brain, and exerts its influence as an adenosine A 1 and A 2A receptor antagonist (for reviews, see Carvey et al 2012 ; Fredholm et al 1999 ). Caffeine has significant effects on arousal of rested individuals (Lieberman et al 1987 ; Smith et al 1999 ; Warburton 1995 ) and substantial positive effects on vigilance, alertness and mood during periods of sleep loss (Kamimori et al 2000 , 2005 ; Lieberman et al 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Caffeine improves reaction time, vigilance and logical reasoning during extended periods with restricted opportunities for sleep

Kamimori

McLellan

Tate³

et al. 2014

Psychopharmacology

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RationaleVarious occupational groups are required to maintain optimal physical and cognitive function during overnight periods of wakefulness, often with less than optimal sleep. Strategies are required to help mitigate the impairments in cognitive function to help sustain workplace safety and productivity.ObjectivesTo test the effectiveness of repeated 200 mg doses of caffeine on cognitive function and live-fire marksmanship with soldiers during three successive nights of sustained wakefulness followed by 4-h afternoon sleep periods.MethodsTwenty Special Forces personnel (28.6 ± 4.7 years, 177.6 ± 7.5 cm and 81.2 ± 8.0 kg) were randomly assigned to receive four 200-mg doses of caffeine (n = 10) or placebo (n = 10) during the late evening and early morning hours during three successive days. An afternoon 4-h sleep period followed. The psychomotor (PVT) and field (FVT) vigilance, logical reasoning (LRT) tests and a vigilance monitor assessed cognitive function throughout the study. Live-fire marksmanship requiring friend–foe discrimination was assessed.ResultsCaffeine maintained speed on the PVT (p < 0.02), improved detection of events during FVT (p < 0.001), increased number of correct responses to stimuli as assessed by the vigilance monitor (p < 0.001) and increased response speed during the LRT (p < 0.001) throughout the three overnight testing periods. Live-fire marksmanship was not altered by caffeine.ConclusionsA total daily dose of 800 mg caffeine during successive overnight periods of wakefulness is an effective strategy to maintain cognitive function when optimal sleep periods during the day are not available.

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Section: Introductionmentioning

confidence: 99%

Caffeine improves reaction time, vigilance and logical reasoning during extended periods with restricted opportunities for sleep

Kamimori

McLellan

Tate³

et al. 2014

Psychopharmacology

Self Cite

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“… 31 The non-sleep-deprived and sleep-deprived individuals experience performance benefits, owing to increased alertness, after consuming 30–300 mg and 200–600 mg of caffeine, respectively. 32 , 33 Notwithstanding the low-quality evidence, caffeine combined with naps can significantly reduce sleepiness during night shifts, as revealed by a Cochrane systematic review published in 2014. 26 Among nightshift workers, the caffeine use is usually associated with improved cognitive performance, mood, and enhanced wakefulness; however, its use may induce tolerance in a significant proportion of individuals.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Prevalence and Patterns of Use of Sleep Aids and Stimulants Among Emergency Physicians and EMS Providers in Saudi Arabia

Kentab

Ibrahim

Soliman

et al. 2021

OAEM

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Purpose This study explores the prevalence and patterns of the use of pharmacologic sleep aids and stimulants among Saudi Arabia’s emergency physicians (EPs) and emergency medical services (EMS) providers. Patients and Methods We adopted a descriptive, cross-sectional design. To collect data on the types and frequencies of sleep aids and stimulants used, we distributed a semi-structured, anonymous, web-based questionnaire to registered EPs, paramedics, and emergency medicine technicians (EMTs) in the Saudi Commission for Health Specialties. An internal consistency analysis showed good reliability (Cronbach’s alpha=0.667) of the questionnaire. A subscale analysis confirmed the results—alpha values were 0.720 and 0.618 for the use of sleep aids and stimulants, respectively. Results Males and females represented 81.8% and 18.2%, respectively, of the valid sample of 669 participants. Respondents aged 25–34, 35–44, and 45–55 years represented 51.9%, 32.7%, and 10.2% of the sample, respectively. Results showed that a majority of the respondents (67.1%) used stimulants. Caffeine was the most common stimulant; caffeine and energy drinks were used by 65.9% and 17.2% of the respondents, respectively. Caffeine, energy drinks, nicotine, and ephedrine were used by 65.9%, 17.2%, 18.5%, and 17.3% of the respondents, respectively. The respondents who used at least one sleeping aid and those using only one and two sleeping aids accounted for 36.6%, 15.6%, and 9.7%, respectively. The most common sleeping aids antihistamines and marijuana were used on most days by 13.4% and 13.3% of the respondents, respectively. The average monthly number of night shifts (P = 0.025) significantly influenced sleep aid use. Respondents working in night shifts for 3–5 months or more than 7 days were more likely to use sleeping aids. Conclusion Future research should enhance health workers’ knowledge of the efficacy and safety of these medications and guide strategies to organize and reduce night shift work.

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“…Caffeine's antinociceptive and adjuvant effects may be explained by adenosine receptor antagonistic effects and suppression of cyclooxygenase activity at particular locations [ 18 - 20 ]. Some experts believe that heredity might affect how people react to coffee [ 21 ].…”

Section: Reviewmentioning

confidence: 99%

Caffeine: What Is Its Role in Pain Medicine?

Boppana¹,

Peterson²,

Du³

et al. 2022

Cureus

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Caffeine is the world's most widely used psychoactive legal substance. The involvement of caffeine in pain management has gotten minimal attention in the past, but it is getting more attention now. This article provides a brief assessment of the literature to clarify the role of caffeine as a pain reliever and stimulate the interest of researchers. Caffeine affects adenosine receptors, which are involved in nociception, and plays a significant role in pain regulation. Caffeine's usage as an adjuvant therapy has been extensively documented in the literature, and it is now accessible in certain over-the-counter drugs. The mixture of coffee and morphine for pain reduction in individuals with terminal cancer has shown mixed outcomes in studies. Caffeine can be utilized for hypnic headaches and post-dural puncture headaches since it is crucial in pain regulation. Caffeine has the potential to help in pain management. Caffeine's usage for migraines and end-stage cancer disease is not well acknowledged. Further research is essential to focus on caffeine's potential role in various forms of pain, including dosage escalation and outcome assessment standardization.

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Caffeine: mechanism of action, genetics, and behavioral studies conducted in task simulators and the field

Cited by 13 publications

References 35 publications

Caffeine improves reaction time, vigilance and logical reasoning during extended periods with restricted opportunities for sleep

Caffeine improves reaction time, vigilance and logical reasoning during extended periods with restricted opportunities for sleep

Exploring the Prevalence and Patterns of Use of Sleep Aids and Stimulants Among Emergency Physicians and EMS Providers in Saudi Arabia

Caffeine: What Is Its Role in Pain Medicine?

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