Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension

Guessous, Idris; Dobrinas, Maria; Kutalik, Zoltán; Pruijm, Menno; Ehret, Georg; Maillard, Marc; Bergmann, Sven; Beckmann, Jacques S.; Cusi, Daniele; Rizzi, Federica; Cappuccio, Francesco P.; Cornuz, Jacques; Paccaud, Fred; Mooser, Vincent; Gaspoz, Jean‐Michel; Waeber, Gérard; Burnier, Michel; Vollenweider, Péter; Eap, Chin B.; Bochud, Murielle

doi:10.1093/hmg/dds137

Cited by 60 publications

(43 citation statements)

References 57 publications

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“…Such conclusions are partially supported by a study by Guessous et al [58], reporting on the influence of the CYP1A2 gene variants also in relation with the effect of smoking, which is known to induce CYP1A2 [59]. In a combined analysis of 4 observational studies (n = 16,719) and 1 quasi-experimental study (n = 106) including European adults, these authors reported that the mean adjusted SBP and diastolic BP decreased with the number of reported caffeinated cups/day in nonsmokers, but this only occurred among fast metabolizers consuming caffeine.…”

Section: Long-term Risk Of Caffeine On Cardiovascular Eventssupporting

confidence: 61%

Moving towards Specific Nutrigenetic Recommendation Algorithms: Caffeine, Genetic Variation and Cardiovascular Risk

Caterina

El‐Sohemy

2016

Lifestyle Genomics

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Recent research has indicated that part of the interindividual variability in cardiovascular responses to caffeine has a genetic basis. Therefore, knowledge of the individual's genetic constitution may allow an individual tailoring of dietary advice for the use of caffeine-containing beverages, yielding an example of the potential of practical translation of nutrigenetic information. This paper reviews the basis for possible nutrigenetic recommendations on the consumption of caffeine, discussing the current gaps in knowledge but also proposing a mode of action in this research area, which may be transposed to other types of similar recommendations.

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Section: Long-term Risk Of Caffeine On Cardiovascular Eventssupporting

confidence: 61%

Moving towards Specific Nutrigenetic Recommendation Algorithms: Caffeine, Genetic Variation and Cardiovascular Risk

Caterina

El‐Sohemy

2016

Lifestyle Genomics

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“…8 In a crosssectional study, high reported caffeine intake was associated with a lower prevalence of hypertension only in nonsmokers. 9 To date, studies on the association of caffeine and BP have been limited by the use of reported caffeine intake instead of Abstract-Intake of caffeinated beverages might be associated with reduced cardiovascular mortality possibly via the lowering of blood pressure. We estimated the association of ambulatory blood pressure with urinary caffeine and caffeine metabolites in a population-based sample.…”

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confidence: 99%

Associations of Ambulatory Blood Pressure With Urinary Caffeine and Caffeine Metabolite Excretions

et al. 2015

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H ypertension is a major risk factor for cardiovascular disease and results from a complex interplay between genetic and environmental factors.1 Intake of caffeinated beverages might be associated with lower cardiovascular mortality.2 Caffeine, >70% of which is provided by coffee consumption, 3 is metabolized by the liver CYP1A2 enzyme into paraxanthine (≈80%), theobromine (≈12%), and theophylline (≈4%). Caffeine and caffeine metabolites are methylxanthines: a family of nonspecific adenosine receptor antagonist with several properties, including diuretic and natriuretic properties. 4,5 The urinary excretion of caffeine and caffeine metabolites is a valid measure of caffeine intake. 6 The relation of blood pressure (BP) with caffeine and caffeine metabolites is of major interest, given their widespread consumption in foods and beverages (eg, coffee, tea, cola drinks, chocolate products) and the public health burden of high BP. Studies on the effect of acute consumption of caffeine at dietary levels on BP produced inconsistent results, 7 with a recent study restricted to nonsmokers showing a decrease in systolic BP (SBP). 8 In a crosssectional study, high reported caffeine intake was associated with a lower prevalence of hypertension only in nonsmokers. 9 To date, studies on the association of caffeine and BP have been limited by the use of reported caffeine intake instead of Abstract-Intake of caffeinated beverages might be associated with reduced cardiovascular mortality possibly via the lowering of blood pressure. We estimated the association of ambulatory blood pressure with urinary caffeine and caffeine metabolites in a population-based sample. Families were randomly selected from the general population of Swiss cities. Ambulatory blood pressure monitoring was conducted using validated devices. Urinary caffeine, paraxanthine, theophylline, and theobromine excretions were measured in 24 hours urine using ultrahigh performance liquid chromatography tandem mass spectrometry. We used mixed models to explore the associations of urinary excretions with blood pressure although adjusting for major confounders. The 836 participants (48.9% men) included in this analysis had mean age of 47.8 and mean 24-hour systolic and diastolic blood pressure of 120.1 and 78.0 mm Hg. For each doubling of caffeine excretion, 24-hour and nighttime systolic blood pressure decreased by 0.642 and 1.107 mm Hg (both P values <0.040). Similar inverse associations were observed for paraxanthine and theophylline. Adjusted night-time systolic blood pressure in the first (lowest), second, third, and fourth (highest) quartile of paraxanthine urinary excretions were 110.3, 107.3, 107.3, and 105.1 mm Hg, respectively (P trend <0.05). No associations of urinary excretions with diastolic blood pressure were generally found, and theobromine excretion was not associated with blood pressure. Anti-hypertensive therapy, diabetes mellitus, and alcohol consumption modify the association of caffeine urinary excretion with systolic blood pressure. 14 in Laus...

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“…However, our finding of a significant effect modification from age is limited by the small size of the sample analyzed for age interaction (N = 1676). The modifying effect of smoking was also evaluated by Guessous et al (2012), but inconsistent results were obtained. Furthermore, a significant association of the CYP1A2 rs762551 AA genotype with high caffeine intake, assessed in 5452 subjects from the CoLaus study, was found among non-smokers (N = 4017; OR = 1.83, 95%CI = 1.38-2.45, P < 0.0001) but not in smokers (N = 1435; OR = 1.15, 95%CI = 0.79-1.67, P = 0.77) with evidence for a significant effect modification.…”

Section: Discussionmentioning

confidence: 99%

“…The following papers were excluded: four GWAS (Cornelis et al, 2011;Sulem et al, 2011;Amin et al, 2012;Rodenburg et al, 2012); four studies lacking coffee intake analysis (Sachse et al, 1999;Basvi et al, 2007;Ghotbi et al, 2007;Gunes et al, 2009); eight studies not providing coffee intake data according to rs762551 genotypes (Goodman et al, 2003;Kotsopoulos et al, 2009;Hallström et al, 2010;Schmidt et al, 2010;Guessous et al, 2012;Josse et al, 2012;Palatini et al, 2015;Yamamoto et al, 2015); two studies providing CC and combined AC + AA genotypes counts instead of AA and AC + CC genotype counts (Palatini et al, 2009;Pavanello et al, 2010); two studies using patient samples (Cornelis et al, 2007;Bågeman et al, 2008); and one study with a small sample size . Finally, 12 studies were included in the meta-analysis (Nordmark et al, 2002;Sata et al, 2005;Cornelis et al, 2006;Kotsopoulos et al, 2007;Tan et al, 2007;Jernström et al, 2008;Djordjevic et al, 2010;Popat et al, 2011;Kohno et al, 2013;Lowcock et al, 2013;Tian et al, 2013;Dik et al, 2014) (Figure 1).…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

Gender and ethnicity modify the association between the CYP1A2 rs762551 polymorphism and habitual coffee intake: evidence from a meta-analysis

Denden¹,

Bouden²,

Khelil³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The association between the single nucleotide polymorphism rs762551 in the cytochrome P450 family 1, subfamily A2 gene (CYP1A2) and caffeine consumption remains controversial. We conducted a metaanalysis to clarify this potential association. Twelve studies were selected from articles retrieved from the and Google Scholar databases, and the data were analyzed to determine the odds ratio (OR) of genotypes AA (conferring fast caffeine metabolism) vs AC + CC (conferring slow caffeine metabolism). Comparisons were made between 6161 high caffeine consumers and 3219 low caffeine consumers. The overall analysis showed a significant association between genotype AA and coffee intake [OR = 1.13, 95% confidence interval (CI) = 1.03-1.24; Q = 19.23, P = 0.06; I 2 = 43%]. In subgroup analyses, the association was also found within male, younger, and Caucasian subjects (OR = 1.21, 95%CI = 1.08-1.35; OR = 1.71, 95%CI = 1.18-2.48; OR = 1.29, 95%CI = 1.12-1.49, respectively) but not in female, older, and Asian subjects (OR = 0.98, 95%CI = 0.83-1.15; OR = 0.83, 95%CI = 0.56-1.22; OR = 0.91, 95%CI = 0.71-1.17, respectively). Therefore, the rs762551 AA genotype may lead to higher coffee intake, especially in males, younger age groups, and individuals of Caucasian ethnicity. Our data highlight the need to test other CYP1A2 polymorphisms showing significance in genome-wide association studies to clarify the association with caffeine intake in the Asian population.

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Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension

Cited by 60 publications

References 57 publications

Moving towards Specific Nutrigenetic Recommendation Algorithms: Caffeine, Genetic Variation and Cardiovascular Risk

Moving towards Specific Nutrigenetic Recommendation Algorithms: Caffeine, Genetic Variation and Cardiovascular Risk

Associations of Ambulatory Blood Pressure With Urinary Caffeine and Caffeine Metabolite Excretions

Gender and ethnicity modify the association between the CYP1A2 rs762551 polymorphism and habitual coffee intake: evidence from a meta-analysis

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