Gender and ethnicity modify the association between the CYP1A2 rs762551 polymorphism and habitual coffee intake: evidence from a meta-analysis

Abstract

ABSTRACT. The association between the single nucleotide polymorphism rs762551 in the cytochrome P450 family 1, subfamily A2 gene (CYP1A2) and caffeine consumption remains controversial. We conducted a metaanalysis to clarify this potential association. Twelve studies were selected from articles retrieved from the and Google Scholar databases, and the data were analyzed to determine the odds ratio (OR) of genotypes AA (conferring fast caffeine metabolism) vs AC + CC (conferring slow caffeine metabolism). Comparisons were made between 6161 high caffeine consumers and 3219 low caffeine consumers. The overall analysis showed a significant association between genotype AA and coffee intake [OR = 1.13, 95% confidence interval (CI) = 1.03-1.24; Q = 19.23, P = 0.06; I 2 = 43%]. In subgroup analyses, the association was also found within male, younger, and Caucasian subjects (OR = 1.21, 95%CI = 1.08-1.35; OR = 1.71, 95%CI = 1.18-2.48; OR = 1.29, 95%CI = 1.12-1.49, respectively) but not in female, older, and Asian subjects (OR = 0.98, 95%CI = 0.83-1.15; OR = 0.83, 95%CI = 0.56-1.22; OR = 0.91, 95%CI = 0.71-1.17, respectively). Therefore, the rs762551 AA genotype may lead to higher coffee intake, especially in males, younger age groups, and individuals of Caucasian ethnicity. Our data highlight the need to test other CYP1A2 polymorphisms showing significance in genome-wide association studies to clarify the association with caffeine intake in the Asian population.

Caffeine Consumption through Coffee: Content in the Beverage, Metabolism, Health Benefits and Risks

“…The analysis showed an association between the AA genotype and coffee consumption [OR = 1.13, 95%, CI = 1.03-1.24, P = 0.06]. This association was found in men, individuals younger than 59 years, and Caucasians, but not in females, individuals older than 59 years, and Asians [206].…”

Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption

“…This is the first study pointing out the weak association between the fast caffeine metabolizer profile and coffee intake in the Asian population, as well as the age-and sex-related variation. These specificities need to be further explored (Denden et al, 2016).…”

13C-caffeine breath test results show high dependence of aryl-hydrocarbon receptor SNPs

“…The ratio of caffeine and its metabolites in plasma and urine after caffeine consumption is known to affect rs762551 polymorphism. Specifically, individuals with genotypes AA, AC, and CC are known as extensive, intermediate, and poor metabolizers of caffeine, respectively [26][27][28][29]. Although we found that genotype CC had a relatively low degree of change in S90m…”

“…There are various polymorphisms in CYP1A2, and SNPs rs762551 and rs2472297 are known to affect the efficiency of caffeine metabolism. Specifically, individuals with rs762551 alleles AA, AC, and CC are characterized as extensive, intermediate, and poor metabolizers of caffeine, respectively [26][27][28].…”