Caffeine, Diabetes, Cognition, and Dementia

Biessels, Geert Jan

doi:10.3233/jad-2010-091228

Cited by 28 publications

(27 citation statements)

References 96 publications

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“…Also, some studies reported that coffee consumption lowers the risk of type 2 diabetes [45,46]. Because insulin may have a role in normal cognitive functioning, and it regulates amyloid precursor protein (APP) and amyloid-β protein, insulin resistance may be associated with the pathophysiology of AD [46]. Besides, caffeine can act against neurodegenerative changes in the brain via positive effects on serum lipids [47,48].…”

Section: Discussionmentioning

confidence: 99%

“…A main antioxidant in coffee is phenol chlorogenic acid (an ester of caffeic acid and quinic acid), which could carry neuroprotective properties against cognitive deterioration [44]. Also, some studies reported that coffee consumption lowers the risk of type 2 diabetes [45,46]. Because insulin may have a role in normal cognitive functioning, and it regulates amyloid precursor protein (APP) and amyloid-β protein, insulin resistance may be associated with the pathophysiology of AD [46].…”

Section: Discussionmentioning

confidence: 99%

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Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Kim

Kwak

Myung³

2015

Neuroepidemiology

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Background: Observational epidemiological studies such as cross-sectional, case-control, and cohort studies have reported inconsistent findings regarding the association between caffeine intake from coffee or tea and the risk of cognitive disorders such as dementia, Alzheimer's disease, cognitive impairment, and cognitive decline. Methods: We searched PubMed and EMBASE in September 2014. Three evaluators independently extracted and reviewed articles, based on predetermined selection criteria. Results: Out of 293 articles identified through the search and bibliographies of relevant articles, 20 epidemiological studies from 19 articles, which involved 31,479 participants (8,398 in six cross-sectional studies, 4,601 in five case-control studies, and 19,918 in nine cohort studies), were included in the final analysis. The pooled odds ratio (OR) or relative risk (RR) of caffeine intake from coffee or tea for cognitive disorders (dementia, Alzheimer's disease, cognitive impairment, and cognitive decline) was 0.82 (95% confidence interval [CI], 0.67-1.01, I² = 63.2%) in a random-effects meta-analysis. In the subgroup meta-analysis by caffeine sources, the summary OR or RR of coffee intake was 0.83 (95% CI, 0.70-0.98; I² = 44.8%). However, in the subgroup meta-analysis by study design, the summary estimates (RR or OR) of coffee intake for cognitive disorders were 0.70 (95% CI, 0.50-0.98; I² = 42.0%) for cross-sectional studies, 0.82 (95% CI, 0.55-1.24; I² = 33.4%) for case-control studies, and 0.90 (95% CI, 0.59-1.36; I² = 60.0%) for cohort studies. Conclusions: This meta-analysis found that caffeine intake from coffee or tea was not associated with the risk of cognitive disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Kim

Kwak

Myung³

2015

Neuroepidemiology

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“…18 In contrast, recent studies have reported health benefits associated with coffee consumption. 19,20 At low doses, caffeine improves hedonic tone and reduces anxiety, while it produces an increase in tense arousal, including anxiety, nervousness, and jitteriness, at high doses. 21 Several studies have found that caffeine can reverse many of the performance-impairing effects of ethanol 22 ; for example, a low dose of caffeine prevented the sleepiness and performance impairment associated with a moderate dose of ethanol.…”

Section: Introductionmentioning

confidence: 99%

Effects of Alcohol, Coffee, and Tobacco, Alone or in Combination, on Physiological Parameters and Anxiety in a Young Population

Vinader‐Caerols

Monleón

Carrasco

et al. 2012

Journal of Caffeine Research

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Objective: The objective was to evaluate the effects of a single dose of alcohol, caffeine, and nicotine, alone or in combination, on physiological parameters (systolic and diastolic blood pressure [SBP and DBP] and heart rate [HR]) and state-trait anxiety in healthy young volunteers. Method: The procedure reproduces the conditions under which the subjects (n = 76) usually ingest alcohol (through an alcoholic beverage), caffeine (through a cup of coffee), and nicotine (by smoking a cigarette), separately or in combination, according to their consumption habits of each individual. SBP and DBP, HR, and state anxiety (SA) were registered before (phase 1) and after (phase 2) treatment. Results: Intake of alcohol or alcohol-nicotine reduced DBP. Comparisons between control and combined treatment (coffee-alcohol-nicotine) groups revealed a decrease in HR in the former group but not in the latter. The coffee consumers alone exhibited a tendency toward an increase in SA, while the control group showed a tendency toward a decrease in this measure. When Phase 1 and Phase 2 were compared, a decrease was observed in SBP (alcohol and coffee-alcohol groups), DBP (alcohol and alcohol-nicotine groups), HR (all groups, except coffeealcohol and coffee-alcohol-nicotine groups), and SA (coffee-alcohol-nicotine group). Conclusions: (i) A low dose of alcohol, either alone or in combination with a cigarette, decreases DBP but not SBP; (ii) the polyconsumption of coffee, alcohol, and nicotine blocks the adaptation response (the reduction in HR in control subjects in the second phase); (iii) an increase of SA is observed after consuming coffee, while the opposite occurs in control subjects (a decrease of SA).

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“…This although can be applied only to nonelderly people who had previously lost weight and there is also positive dose-response relationship between diabetes risk and weight change [7]. Caffeine/coffee consumption is associated with a decreased risk of diabetes type 2 and possibly also with a decreased dementia risk, although further research is needed [8].…”

Section: Caffeinementioning

confidence: 99%

Pharmacological Value of Caffeine, Taurine and Arginine in Nutritional Supplements and their Relation to Well Known Socially Important Diseases

Yotova¹

2015

IJNFS

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Email address: M_jotova@mu-pleven Abstract: Caffeine, Taurine and Arginine are one of the most widely used supplements from people of all ages. There are lot of controversial information about their proper use and effects and side effects. Our goal is to determine the reasonable boundaries of using these supplements in healthy people and more important in people with socially important diseases like high blood pressure, diabetes and dementia.

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Caffeine, Diabetes, Cognition, and Dementia

Cited by 28 publications

References 96 publications

Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Caffeine Intake from Coffee or Tea and Cognitive Disorders: A Meta-Analysis of Observational Studies

Effects of Alcohol, Coffee, and Tobacco, Alone or in Combination, on Physiological Parameters and Anxiety in a Young Population

Pharmacological Value of Caffeine, Taurine and Arginine in Nutritional Supplements and their Relation to Well Known Socially Important Diseases

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