Caffeine antagonizes several central effects of diazepam

Effects of Caffeine on Monoamine Neurotransmitters in the Central and Peripheral Nervous System

“…For example, a limited number of studies show methylxanthine effects in GABA (e.g. Sytinskii and Priyatkina 1966;Scholfield 1982), on the ability of drugs to influence acetylcholine release (Jhamandas et al 1978), and on the central nervous system actions of benzodiazepines (e. g., Marangos et al 1979;Polc et al 1981). Perhaps future studies will show these foci of methylxanthine action to be important in mediating some or all of the central nervous system effects of caffeine.…”

The relationship between subjective and objective measures of sleepiness.

“…Though the N of the placebo group was only 10, at 0700 h the correlation between "SUT and SSS in that group was -0.85 (p -0.001) falling to .. 03 by 1100 It. It is ot interest that caffeine effectively abolished the nogatlve relationship between MSLT and SSS, and that the regression line had an insignifica t positive slope (21,22). But this treatment effect of caffeine was a sigri ficant factor only in the early morning trial.…”

Behavioral effects of adenosine agonists: Evaluation by punishment, discrete shuttle avoidance and activity tests in mice.

“…Particularly, the effect of PIA appeared at comparatively lower doses, suggesting that there is an intimate interaction between adenosine and benzodiazepine systems with respect to the change in the punished response, and that these two systems show an antagonistic interaction. Many researchers (6,(30)(31)(32) have also reported that adenosine agonists could reduce the benzodiazepine-induced increase in exploratory behavior, food intake, lever-pressing for food reinforcement, etc. in squirrel monkeys, rats and mice.…”