Effects of Caffeine on Monoamine Neurotransmitters in the Central and Peripheral Nervous System

Fernstrom, John D.; Fernstrom, Madelyn H.

doi:10.1007/978-3-642-69823-1_7

Cited by 19 publications

(11 citation statements)

References 60 publications

(65 reference statements)

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“…Secondly, Fredholm (1985) has suggested that caffeine's primary actions in humans are mediated via adenosine antagonism, namely sympathetic stimulation and catacholamine release. It has further been suggested that blockade of adenosine receptors may increase neuronal activity and facilitate motor unit recruitment (Fernstrom and Fernstrom, 1984). However, Van Handle (1983) has noted that the sympathetic response to maximal work stress might be of such magnitude that it supercedes the caffeine-induced changes observed in vitro, in situ or resting in vivo investigations.…”

Section: Resultsmentioning

confidence: 99%

Caffeine, maximal power output and fatigue.

et al. 1988

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The purpose of this investigation was to determine the effects of caffeine ingestion on maximal power output and fatigue during short term, high intensity exercise. Nine adult males performed 15 s maximal exercise bouts 60 min after ingestion of caffeine (7 mg.kg-1) or placebo. Exercise bouts were carried out on a modified cycle ergometer which allowed power output to be computed for each one-half pedal stroke via microcomputer. Peak power output under caffeine conditions was not significantly different from that obtained following placebo ingestion. Similarly, time to peak power, total work, power fatigue index and power fatigue rate did not differ significantly between caffeine and placebo conditions. These results suggest that caffeine ingestion does not increase one's maximal ability to generate power. Further, caffeine does not alter the rate or magnitude of fatigue during high intensity, dynamic exercise.

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Section: Resultsmentioning

confidence: 99%

Caffeine, maximal power output and fatigue.

et al. 1988

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“…Namely, caffeine increases bronchodilation, systolic blood pressure, and heart rate, and decreases peripheral vascular resistance and cerebral blood flow (Robertson and Curatolo 1984;Rall 1985). Furthermore, several studies have indicated that dopamine synthesis, turnover, and/or release may also be affected by caffeine administration (see Fernstrom and Fernstrom 1984). Caffeine may also play a role in the pharmacokinetics of cocaine as measured in rat serum by high-performance liquid chromatography (Lau et al 1990).…”

Section: Discussionmentioning

confidence: 99%

Oral caffeine pretreatment produced modest increases in smoked cocaine self-administration in rhesus monkeys

Comer

Carroll

1996

Psychopharmacology

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Several recent studies have shown that caffeine potentiates the reinforcing, discriminative stimulus, and motor activating effects of cocaine in rats. The present study was designed to determine whether oral caffeine pretreatment would enhance the reinforcing effects of cocaine in rhesus monkeys trained to self-administer smoked cocaine base. The effects of oral caffeine pre-treatment (0, 100, or 200 mg) and fixed-ratio (FR) value on cocaine-base smoking were evaluated in four male rhesus monkeys. Monkeys responded on a lever under a fixed-ratio (FR) schedule (FR 128, 256, 512, 1024, 2048, or 4096) and then made five inhalations on a smoking spout to gain access to volatilized cocaine base (0.25 or 1.0 mg/kg per delivery) during daily experimental sessions. Twenty pellets [20 non-caffeinated (0 mg caffeine), ten non-caffeinated+ten caffeinated (100 mg caffeine), or 20 caffeinated (200 mg caffeine) pellets] were administered 30 min prior to experimental sessions. The lever FR value was held constant within each experimental session, but was increased after 3 consecutive days of stable responding. Although the number of smoke deliveries that was self-administered significantly decreased from FR 128 to FR 4096, it did not change as a function of cocaine dose across the range of FR values tested. However, the interaction between cocaine dose and caffeine pretreatment was statistically significant. Compared to 0 mg caffeine, three of four monkeys pretreated with 200 mg caffeine responded for a greater number of smoke deliveries when they were maintained on a cocaine dose of 1.0 mg/kg per delivery, but not 0.25 mg/kg per delivery. Thus, caffeine pretreatment can produce small, but statistically significant increases in smoked cocaine self-administration in rhesus monkeys.

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“…However, as always, extrapolation from in-vitro data to the in-vivo situation should be treated with great caution. The action of caffeine might be exerted not at the hypotha¬ lamic level, but upon the neurotransmitter pathways impinging upon it, as the drug increases the production in the brain of 5-hydroxytryptamine and noradrenaline (Fernstrom & Fernstrom, 1984;Hirsch, 1984), both of which are implicated in the control of CRF secretion. Alternatively, it might be that caffeine is exerting its effect through blockade of adenosine receptors (Fredholm, 1980;Rail, 1982), which occurs at concen¬ trations far lower than those required to inhibit phos¬ phodiesterase, and much closer to those existing in the blood after caffeine injection.…”

Section: In Vivomentioning

confidence: 99%

“…However, these findings are of interest in that they may elucidate further the processes involved in the control of this neuroendocrine system. Administration of caffeine has been reported by several workers to increase the concentration and turnover in the brain of 5-hydroxytryptamine and noradrenaline respectively (for reviews see Fernstrom & Fernstrom, 1984;Hirsch, 1984), two neurotransmitters which are thought to control the release of corticotrophin-releasing factor (CRF) from the hypothalamus (Jones, 1978). The purpose of this study was to investigate at which site in the axis caffeine exerts its action to cause a rise in plasma corticosterone concentrations.…”

Section: Introductionmentioning

confidence: 99%

Stimulatory effect of caffeine on the hypothalamo-pituitary-adrenocortical axis in the rat

Nicholson¹

1989

Journal of Endocrinology

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Intraperitoneal injection of caffeine (12.5-100 mg/kg) into rats caused a significant, dose-related increase in plasma corticosterone 2 h later, when the greatest response was measured. The corticosterone response to laparotomy stress or i.v. injection of ACTH(1-24) was unaffected by prior injection of caffeine. The response to stress or caffeine was unaffected by adrenal enucleation 28 days previously. In vitro, 10 mmol caffeine/l stimulated basal release of corticosterone from adrenal quarters and potentiated the response to a sub-maximal stimulatory concentration of cyclic AMP (cAMP). The drug had no effect on release stimulated by a sub-maximal concentration of ACTH(1-24). Release of ACTH from pituitary fragments incubated in vitro was stimulated in a dose-related manner by caffeine (0.01-10 mmol/l), and the responses to hypothalamic extract and sub-maximal concentrations of corticotrophin-releasing factor (CRF-41) or arginine vasopressin (AVP), but not cAMP, were significantly enhanced by 10 mmol caffeine/l. Release of immunoreactive CRF-41 (but not AVP) was significantly increased by caffeine (0.01-10 mmol/l) added to hypothalami incubated in vitro. The response to injection of caffeine in vivo was completely prevented by pharmacological blockade of endogenous CRF release. Taken together, these results show that caffeine at high concentrations can stimulate directly the release of the hormones of the hypothalamo-pituitary-adrenocortical axis in vitro, but the fact that these concentrations are unlikely to be reached after administration in vivo suggests that the effect of caffeine may be mediated centrally.

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Effects of Caffeine on Monoamine Neurotransmitters in the Central and Peripheral Nervous System

Cited by 19 publications

References 60 publications

Caffeine, maximal power output and fatigue.

Caffeine, maximal power output and fatigue.

Oral caffeine pretreatment produced modest increases in smoked cocaine self-administration in rhesus monkeys

Stimulatory effect of caffeine on the hypothalamo-pituitary-adrenocortical axis in the rat

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