Caffeine and seizures: A systematic review and quantitative analysis

Koert, Rick R. van; Bauer, Prisca R.; Schuitema, Ilse; Sander, Josemir W.; Visser, Gerhard H.

doi:10.1016/j.yebeh.2017.11.003

Cited by 69 publications

(57 citation statements)

References 91 publications

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“…So far, the role of caffeine in the control of epilepsy is unclear. Studies on animal models suggest that, depending on the dose and length of caffeine intake, it may have both positive and negative effects on seizure control [44,45]. Moreover, caffeine may reduce the effectiveness of some anticonvulsant drugs, mainly topiramate [46].…”

Section: Discussionmentioning

confidence: 99%

Dietary and Lifestyle Behavior in Adults With Epilepsy Needs Improvement: A Case-control Study From North-eastern Poland

Kulesza

Cyuńczyk

Kochanowicz

et al. 2020

Preprint

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Background: Several factors predispose people with epilepsy to cardiovascular diseases. Among them nutrition and lifestyle have not been sufficiently studied. Methods. The study involved 60 epileptic male and female volunteers and 70 healthy controls, corresponding to age and gender. Medical information was collected during the study and a detailed questionnaire survey concerning eating and lifestyle habits was conducted. Physical activity was evaluated using International Physical Activity Questionnaire (IPAQ). Nutritional status was assessed by bioelectric impedance. Venous blood samples were taken for lipid and 25-hydroxyvitamin D3 (25(OH)D3) analyses. Results. A tendency to an increase in LDL cholesterol was found in epileptics. Significantly higher body fat and insignificantly higher visceral fat was found in epileptic men compared to healthy men. In epileptic women a tendency to lower lean body mass was found. Patients with epilepsy were more sedentary, had lower consumption of cottage cheese, fruit, pulses, nuts and seeds, vitamin C and potassium, and higher intake of sugar-sweetened soda, energy from fat and sodium compared to healthy people. As a positive point, epileptics consumed less coffee and alcoholic beverages. More than 80% of diets of epilepsy people were low in folic acid, vitamin D and calcium, but similar tendency was observed in the healthy people. The diets of patients with epilepsy were in a higher percentage poor in niacin, vitamin C and potassium compared to the control group, 25% to 7%, 50% to 31% and 73 to 56% respectively. A significantly lower serum concentration of 25(OH)D3 was observed in epileptic individuals, which in this group was found to be positively modulated by physical activity.Conclusions. The study indicates that several behavior-related habits, which may predispose epileptic people to cardiovascular disease, need to be improved. For this reason, patients with epilepsy should be provided with more comprehensive medical care, including advice on nutrition and physical activity.

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Section: Discussionmentioning

confidence: 99%

Dietary and Lifestyle Behavior in Adults With Epilepsy Needs Improvement: A Case-control Study From North-eastern Poland

Kulesza

Cyuńczyk

Kochanowicz

et al. 2020

Preprint

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“…Abuse in caffeine consumption can cause such health problems as a greater risk of suffering convulsions, development of arrhythmias, and a reduced hypoxic response (Ilback et al 2007;Vesoulis et al 2016;Van Koert et al 2018;Qian et al 2019). Studies of species like dogs and rats have demonstrated that caffeine increases neurotoxicity and makes organisms more prone to suffering convulsions (Basset et al 2014).…”

Section: Neurotoxic Effectsmentioning

confidence: 99%

“…The use of other methylxanthines -e.g. theophylline-has been associated with convulsions in rats (Yasuhara and Levy;, though its neurotoxic effect depends on such factors as treatment duration, interaction with other drugs, and dosage (Van Koert et al 2018;Alasmari, 2002). The latter factor has been shown to promote neurotoxicity in the granular cells of the cerebellum of rat offspring, which is significant for the onset of convulsions (Gepdiremen et al 1988).…”

Section: Neurotoxic Effectsmentioning

confidence: 99%

Neurobehavioral and neuroprotector effects of caffeine in animal models

Villanueva-García

Mota-Rojas

Miranda-Cortés

et al. 2020

JABB

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This review aims to analyze and contrast the neurological effects associated with the use of caffeine on neurobehavior and neuroprotection in animal models. Caffeine belongs to the group of methylxanthines that exert a direct effect on adenosine receptors associated with inhibitory or excitatory G proteins, generating modification of cyclic AMP activity and intracellular calcium flow which produces alterations in the modulation system of the neurotransmitters dopamine and glutamate. The regulation of the neurotransmission systems generates protection against the inflammation of the central nervous system, by activation of the microglia and reinforcement of the blood-brain barrier. This drug will also restore cognition or prevent memory loss in Parkinson's or Alzheimer's diseases. It is important to establish new study models in other species to assess whether the behavior of the molecule is similar and to obtain other clinical applications in its behavioral and neuroprotective effects.

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“…However, in 60% of cases the aetiology is unknown [9] and referred to as 'idiopathic epilepsy' [4]. Lack of sleep [10], stress and anxiety [11], hyperventilation [12] and high caffeine intake can increase seizure susceptibility (although long term low intake can protect from seizures [13]). Epilepsy is primarily controlled pharmacologically, through prescription AEDs, just over half of those taking medication will become seizure free.…”

Section: Epilepsymentioning

confidence: 99%

A Gluten Free Diet in the Management of Epilepsy in People with Coeliac Disease or Gluten Sensitivity

Gilbey

Bold

2020

Gastrointestinal Disorders

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The aim of this review was to assess the effects of a gluten free diet (GFD) in the management of epilepsy in people with coeliac disease (CD) or gluten sensitivity (GS). A systematic approach was used to undertake a literature review. Five electronic databases (PubMed; Scopus; Google Scholar; Cochrane Epilepsy Group specialised register; Cochrane Register of Controlled Trails (CENTRAL) via the Cochrane Register of Online Trials) were searched using predetermined relevant search terms. In total, 668 articles were identified. Duplicates were removed and predefined inclusion and exclusion criteria were applied, and a PRISMA flow chart was produced. Data was extracted using Covidence software. Twelve studies on Epilepsy and CD involving a total of 70 participants were selected for analysis; narrative synthesis was used owing to the small sample sizes in the selected studies. None of the 12 studies meeting inclusion criteria investigated gluten sensitivity and epilepsy. All the included studies support a link between epilepsy and CD. GFD was effective in 44 out of 70 participants across the studies in terms of a reduction of seizures, reduction of antiepileptic drugs (AEDs) or normalisation of EEG pattern. A total of 44 participants showed a reduction in seizures (across eight studies) and complete cessation of seizures was reported in 22 participants. In general, the earlier the GFD is implemented after the onset of seizures, the better the likelihood of the GFD being successful in supporting control of seizures. Mechanisms linking gluten with epilepsy are not fully understood; possible hypotheses include gluten mediated toxicity, immune-induced cortical damage and malabsorption. Evidence suggests the effectiveness of a GFD in supporting the management of epilepsy in patients with CD, although the quality of evidence is low. There appears to be a growing number of neurologists who are prepared to advocate the use of a GFD. A multidisciplinary approaches and further research are recommended. It could be argued that when balancing potential treatments such as AEDs or surgery, a GFD has a low likelihood of harm.

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Caffeine and seizures: A systematic review and quantitative analysis

Cited by 69 publications

References 91 publications

Dietary and Lifestyle Behavior in Adults With Epilepsy Needs Improvement: A Case-control Study From North-eastern Poland

Dietary and Lifestyle Behavior in Adults With Epilepsy Needs Improvement: A Case-control Study From North-eastern Poland

Neurobehavioral and neuroprotector effects of caffeine in animal models

A Gluten Free Diet in the Management of Epilepsy in People with Coeliac Disease or Gluten Sensitivity

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