Caffeine and caffeinated beverage consumption and fecundability in a preconception cohort

Wesselink, Amelia K.; Wise, Lauren A.; Rothman, Kenneth J.; Hahn, Kristen A.; Mikkelsen, Ellen M.; Mahalingaiah, Shruthi; Hatch, Elizabeth E.

doi:10.1016/j.reprotox.2016.04.022

Cited by 46 publications

(53 citation statements)

References 39 publications

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“…Specifically, among 3628 women planning a pregnancy in Denmark the adjusted fecundability ratios were 0.89 (0.80–0.98), 0.85 (0.71–1.02), 0.84 (0.57–1.25), and 0.48 (0.21–1.13) for < 1, 1, 2, and 3+ servings per day, respectively, compared with none (16). This inverse association with fecundity, however, was not confirmed in a more recent prospective study among 2135 North American pregnancy planners (11). Moreover, in this same cohort of women, there was no link between pre-pregnancy soda consumption and pregnancy loss (35).…”

Section: Discussionmentioning

confidence: 81%

“…Insulin resistance is a situation in which the responsiveness of the body to the hormone insulin is diminished, resulting in metabolic dysregulation (30, 31). Insulin resistance can alter the maternal metabolic environment and follicular fluid microenvironment, leading to lower quality oocytes and embryos (9, 11, 32). In mice, this condition leads to altered mitochondrial function and abnormal spindle formation (33).…”

Section: Discussionmentioning

confidence: 99%

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Association between preconception maternal beverage intake and in vitro fertilization outcomes

Machtinger

Gaskins

Mansur

et al. 2017

Fertility and Sterility

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Objective To study whether maternal intake of beverage type affect IVF outcomes Design A prospective study Setting Tertiary, University-affiliated center. Patient (s) 340 women undergoing IVF from 2014 through 2016 for infertility as well as for pre-genetic diagnosis for autosomal recessive diseases were enrolled during ovarian stimulation and completed a questionnaire describing their usual beverage consumption . Intervention(s) none Main Outcome Measure (s) IVF outcomes were abstracted from medical records. Total caffeine intake was estimated by summing the caffeine content for specific beverages multiplied by frequency of intake. Associations between specific types of beverages and IVF outcomes were analyzed using Poisson and logistic regression models adjusting for possible confounders. Result (s) Higher intake of sugared soda was associated with lower total, mature, and fertilized oocytes and top quality embryos following ovarian stimulation. Women who consumed sugared soda had, on average, 1.1 fewer oocytes retrieved, 1.2 fewer mature oocytes retrieved, 0.6 fewer fertilized oocytes and 0.6 fewer top quality embryos compared to women who did not consume sugared soda. Furthermore, compared to women who did not drink sugared soda, the adjusted difference in percent of cycles resulting in live birth for women consuming 0.1–1 cups/day and >1 cup/day were −12% and −16%, respectively (p-trend=0.01). No associations were found between consumption of coffee, caffeine or diet sodas and IVF outcome. Conclusion (s) Sugared beverages, independently of their caffeine content, may be a bigger threat to reproductive success than caffeine and caffeinated beverages without added sugar.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Association between preconception maternal beverage intake and in vitro fertilization outcomes

Machtinger

Gaskins

Mansur

et al. 2017

Fertility and Sterility

View full text Add to dashboard Cite

show abstract

“…Any damage to Sertoli cells will result in a decrease of inhibin B and an increase in the levels of FSH [25,26], both hormones that might help to determine the mechanisms of action of energy drinks in further studies. Interestingly, in a preconception cohort, a recent study showed that caffeinated soda and energy drink intake were associated with reduced fecundability among males, but not among females [27]. Testosterone levels did not show any difference between the control and treated groups (Table 2).…”

Section: Discussionmentioning

confidence: 87%

Effects of energy drinks on biochemical and sperm parameters in Wistar rats

Schuchowsky

Schaefer

Salvador

et al. 2017

Nutrire

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Background: The present study evaluates the effects of energy drinks on the reproductive and biochemical parameters of adult male rats. Methods: A total of 40 male rats (Wistar) were exposed to an energy drink mixed with the drinking water for a period of 120 days. The animals were divided into four groups and exposed to increasing therapeutic doses (DT) of an energy drink, based on allometric extrapolation, resulting in values (mL/day) per animal of 250 g: DT1 2.36 mL, DT3 7.47 mL, and DT6 14.16 mL. The control group (CTRL) consumed water only. During the treatment, the rats were assessed for signs of toxicity. After treatment, the animals were sacrificed and their organs were weighed. Sperm parameters (motility, concentration, and morphology) were evaluated. The biochemical markers alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactic dehydrogenase, urea, creatinine, creatine phosphokinase, and creatine kinase MB fraction were measured, in addition to total cholesterol and testosterone. Results: There was a significant decrease (p < 0.05) in the concentration of sperm in the treated groups (DT1 8.5 ± 0.7; DT3 7.2 ± 0.9; DT6 8.4 ± 0.9) compared to the control group (12.3 ± 1.2). No difference was observed with respect to relative weights of the animals' organs, water consumption, signs of toxicity, behavioral changes, biochemical markers, and sperm motility and morphology. Conclusion: The long-term consumption of energy drinks interferes negatively with sperm concentration, without affecting sperm motility and morphology or altering the hepatic, cardiac, or renal functions.

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“…The reason for paternal strong tea drinking increasing the risk of NSCL/P might be attributed to caffeine, which was a plant alkaloid in teas. Evidences from both animal experiments and human studies [38–40] demonstrated that the intake of caffeine and caffeinated beverages among males could impair reproductive organs, sperm characteristics, and sperm quality, affect fertility and fetal health, and even cause birth defects. Eight predictors selected by a discriminant analysis were with good representativeness and availability.…”

Section: Discussionmentioning

confidence: 99%

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

Luo

et al. 2016

BMC Pregnancy Childbirth

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BackgroundA risk prediction model of non-syndromic cleft lip with or without cleft palate (NSCL/P) was established by a discriminant analysis to predict the individual risk of NSCL/P in pregnant women.MethodsA hospital-based case–control study was conducted with 113 cases of NSCL/P and 226 controls without NSCL/P. The cases and the controls were obtained from 52 birth defects’ surveillance hospitals in Hunan Province, China. A questionnaire was administered in person to collect the variables relevant to NSCL/P by face to face interviews. Logistic regression models were used to analyze the influencing factors of NSCL/P, and a stepwise Fisher discriminant analysis was subsequently used to construct the prediction model.ResultsIn the univariate analysis, 13 influencing factors were related to NSCL/P, of which the following 8 influencing factors as predictors determined the discriminant prediction model: family income, maternal occupational hazards exposure, premarital medical examination, housing renovation, milk/soymilk intake in the first trimester of pregnancy, paternal occupational hazards exposure, paternal strong tea drinking, and family history of NSCL/P. The model had statistical significance (lambda = 0.772, chi-square = 86.044, df = 8, P < 0.001). Self-verification showed that 83.8 % of the participants were correctly predicted to be NSCL/P cases or controls with a sensitivity of 74.3 % and a specificity of 88.5 %. The area under the receiver operating characteristic curve (AUC) was 0.846.ConclusionsThe prediction model that was established using the risk factors of NSCL/P can be useful for predicting the risk of NSCL/P. Further research is needed to improve the model, and confirm the validity and reliability of the model.

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Caffeine and caffeinated beverage consumption and fecundability in a preconception cohort

Cited by 46 publications

References 39 publications

Association between preconception maternal beverage intake and in vitro fertilization outcomes

Association between preconception maternal beverage intake and in vitro fertilization outcomes

Effects of energy drinks on biochemical and sperm parameters in Wistar rats

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

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