Caffeic acid phenethyl ester suppresses eotaxin secretion and nuclear p-STAT6 in human lung fibroblast cells

Lin, Ying-Jui; Hsu, Jeng-Yuan; Chen, Ciao-Jin; Chu, Jao-Jia; Fu, Lin-Shien

doi:10.1016/j.jmii.2011.04.008

Cited by 7 publications

(2 citation statements)

References 30 publications

(20 reference statements)

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“…The suppressive capacities of these 13 compounds on the secretion of RANTES, eotaxin and eotaxin-3 were evaluated in BEAS-2B cells. The BEAS-2B cell line was induced using TNF-α or TNF-α in combination with IL-4, as it was reported that their combination may enhance the production of eotaxin in human lung fibroblasts, airway epithelial cells, smooth muscle cells and dermal fibroblasts (28).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory activity of Socheongryong-tang and its constituent components against the production of RANTES, eotaxin, eotaxin-3 and MMP-9 from BEAS-2B cells

Jeon

Lee

Seo

et al. 2014

Molecular Medicine Reports

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Socheongryeong‑tang (SCRT) is a herbal formula previously used to treat pulmonary diseases primarily caused by the common cold virus, including airway inflammation, asthma and allergy. The aim of the present study was to investigate the inhibitory effect of SCRT water extract and its 13 constituent components on chemokine and enzyme production in the human bronchial epithelium cell line BEAS‑2B when induced by tumor necrosis factor‑α and interleukin‑4. The chemokines examined included regulated on activation of normal T‑cell‑expressed‑and‑secreted (RANTES), eotaxin and eotaxin‑3. The SCRT water extract demonstrated a dose‑dependent inhibition of RANTES, eotaxin, eotaxin‑3 and matrix metalloproteinase‑9 (MMP‑9) in BEAS‑2B cells. The 13 constituent compounds of SCRT water extract were quantitatively determined, and it was found that gallic acid, 6‑gingerol and methyl eugenol produced the most potent inhibition of RANTES, eotaxin and eotaxin‑3 as well as MMP‑9 activity regardless of their concentration in SCRT water extract. Principal component analysis and hierarchical clustering analysis revealed that the inhibitory effect of these three compounds contributed to that of SCRT water extract. In conclusion, the results of the present study indicated that the inhibitory effects of SCRT on chemokine and enzyme production in BEAS‑2B cells was associated with three of its constituent compounds, gallic acid, 6‑gingerol and methyl eugenol. This therefore suggested the potential use of these compounds as anti‑inflammatory agents.

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Section: Discussionmentioning

confidence: 99%

Inhibitory activity of Socheongryong-tang and its constituent components against the production of RANTES, eotaxin, eotaxin-3 and MMP-9 from BEAS-2B cells

Jeon

Lee

Seo

et al. 2014

Molecular Medicine Reports

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“…Caffeic acid phenethyl ester (CAPE) is derived from different plants and is a bioactive constituent found in bee propolis that may have pharmacological applications. Recently, a wide range of pharmacological properties were demonstrated for this substance, including antiinflammatory, antioxidant, antiproliferative, and immunomodulatory activities (6)(7)(8). The prominent protective property of CAPE makes it a potential therapeutic compound against damage to the kidneys, brain, lungs, and other tissues or organs.…”

Section: Introductionmentioning

confidence: 99%

Caffeic acid phenethyl ester protects lung alveolar epithelial cellsfrom cigarette smoke-induced damage

Barlas¹,

Erdoğan²

2015

Turk J Med Sci

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Background/aim: To evaluate the influence of caffeic acid phenethyl ester (CAPE) on cigarette smoke (CS)-induced cell damage, oxidative stress, and inflammation in human alveolar epithelial cells.Materials and methods: A549 alveolar epithelial cells were divided into control, CS exposure, CAPE, and CS+CAPE treatment groups. Undiluted CS-exposed medium (100%) and three dilutions (50%, 25%, and 10%) of CS-exposed media were applied to cultured A549 cells, which were analyzed after 3 h of incubation. Viability was measured by MTT assay, the gene expressions were evaluated by realtime PCR, and spectrophotometric techniques were used for biochemical assessments.Results: While CS exposure markedly reduced cellular viability by 32% after 3 h of incubation, 2.5 µM CAPE treatments prevented CSinduced cell death by 40% in the cells. CS exposure triggered lipid peroxidation and depleted antioxidant capacity through inhibiting catalase activity and depleting glutathione levels. Moreover, CS increased nitric oxide production via upregulation of iNOS expression. CAPE treatment significantly restored antioxidant capacity and prevented lipid peroxidation. Cigarette smoke exposure induced inflammation by significantly upregulating TNF-α, IL-1β, and COX-2 mRNA expressions (3-, 2-and 25-fold, respectively). CAPE treatment of A549 cells significantly reversed the inflammation. Conclusion:CAPE may potentially represent a new therapeutic option in the prevention of CS-induced lung damages.

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Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice

Kashiwakura

Yoshihara

Saitoh

et al. 2021

Allergology International

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Caffeic acid phenethyl ester suppresses eotaxin secretion and nuclear p-STAT6 in human lung fibroblast cells

Cited by 7 publications

References 30 publications

Inhibitory activity of Socheongryong-tang and its constituent components against the production of RANTES, eotaxin, eotaxin-3 and MMP-9 from BEAS-2B cells

Inhibitory activity of Socheongryong-tang and its constituent components against the production of RANTES, eotaxin, eotaxin-3 and MMP-9 from BEAS-2B cells

Caffeic acid phenethyl ester protects lung alveolar epithelial cellsfrom cigarette smoke-induced damage

Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice

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