Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice

Kashiwakura, Jun‐ichi; Yoshihara, Mari; Saitoh, Kunimasa; Kagohashi, Kota; Sasaki, Yuto; Kobayashi, Fuki; Inagaki, Iori; Kitai, Yuichi; Muromoto, Ryuta; Matsuda, Tadashi

doi:10.1016/j.alit.2020.11.005

Cited by 9 publications

(10 citation statements)

References 38 publications

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“…Phosphorylation of FcεRI signaling molecules Lyn, Akt, and ERK was inhibited in basophils treated with propolis. Propolis also down-regulated IgE mediated- chronic allergic inflammation (IgE-CAI) and attenuated basophils-and-basophil-derived IL-4-induced intestinal anaphylaxis [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Recent Update on the Anti-Inflammatory Activities of Propolis

et al. 2022

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In recent years, research has demonstrated the efficacy propolis as a potential raw material for pharmaceuticals and nutraceuticals. There is limited report detailing the mechanisms of action of propolis and its bioactive compounds in relation to their anti-inflammatory properties. Thus, the aim of the present review is to examine the latest experimental evidence (2017–2022) regarding the anti-inflammatory properties of propolis. A systematic scoping review methodology was implemented. After applying the exclusion criteria, a total of 166 research publications were identified and retrieved from Scopus, Web of Science, and Pubmed. Several key themes related to the anti-inflammatory properties of propolis were subsequently identified, namely in relation to cancers, oral health, metabolic syndrome, organ toxicity and inflammation, immune system, wound healing, and pathogenic infections. Based on the latest experimental evidence, propolis is demonstrated to possess various mechanisms of action in modulating inflammation towards the regulatory balance and anti-inflammatory environment. In general, we summarize that propolis acts as an anti-inflammatory substance by inhibiting and downregulating TLR4, MyD88, IRAK4, TRIF, NLRP inflammasomes, NF-κB, and their associated pro-inflammatory cytokines such as IL-1β, IL-6, IFN-γ, and TNF-α. Propolis also reduces the migration of immune cells such as macrophages and neutrophils, possibly by downregulating the chemokines CXCL9 and CXCL10.

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Section: Resultsmentioning

confidence: 99%

Recent Update on the Anti-Inflammatory Activities of Propolis

et al. 2022

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“…In a study by Kashiwakura et al (2021), bone marrow-derived basophils (BMBs) induced with DNP 23 -human serum albumin (HSA) and treated with propolis at a concentration of 100 μg/ml showed a significantly reduced production of pro-inflammatory cytokines, IL-4, IL-6 and IL-13, by inhibiting the phosphorylation of Lyn, protein kinase B (Akt) and extracellular signal-regulated kinase (Erk) (Kashiwakura et al, 2021). Consistent with the in vitro finding, Kashiwakura et al (2021) demonstrated that propolis treatment suppressed basophil-mediated skin and allergic intestinal inflammation in vivo using ovalbumin (OVA)-induced mouse models of chronic allergic inflammation (CAI) and food allergy, respectively. In the mouse model of CAI, propolis (0.3 mg) administered intragastrically reduced skin thickness and inflammation of ears.…”

Section: Basophil-mediated Allergic Inflammationmentioning

confidence: 98%

Anti-Allergic Properties of Propolis: Evidence From Preclinical and Clinical Studies

Liew

Kamise²,

Ong³

et al. 2022

Front. Pharmacol.

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Allergic diseases are a global health burden with increasing prevalence. Side effects of available medications (antihistamines and steroids), lack of patients’ perceived effectiveness and high cost of biologic therapies (omalizumab) are challenges to the clinical management of allergic diseases. As allergy symptoms persist for a long time, complementary and alternative medicine (CAM) such as propolis may be considered a potential prophylactic or therapeutic option to avoid long-term medication use. Propolis is a natural resinous substance produced by bees. Although propolis is well known to possess antioxidant, antimicrobial, and anticancer properties, its anti-allergic potential is not fully explored. Several preclinical studies demonstrated the therapeutic effects of propolis extracts against allergic inflammation, asthma, allergic rhinitis, atopic dermatitis, and food allergy, which may be partly attributed to their inhibitory effects on the activation of mast cells and basophils. Clinically, the consumption of propolis as a supplement or an adjunct therapy is safe and attenuates various pathological conditions in asthma. Such an approach may be adopted for atopic dermatitis and allergic rhinitis. Although flavonoids (chrysin, kaempferol, galangin, and pinocembrin) and cinnamic acid derivatives (artepillin C and caffeic acid phenethyl ester) can contribute to the anti-allergic activities, they may not be present in all propolis samples due to variations in the chemical composition. Future studies should relate the anti-allergic activity of propolis with its chemical contents. This mini-review summarizes and discusses existing preclinical and clinical studies reporting the anti-allergic activities of propolis to provide insights into its potential applications in allergic diseases.

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“…Propolis has inhibitory effects on prooxidative enzymes, such as myeloperoxidase activity, NADPH-oxidase [ 71 , 126 ], ornithine decarboxylase, tyrosine-protein-kinase, and hyaluronidase from guinea pig mast cells [ 126 ] reducing the level of ROS production and accumulation of inflammatory cells. This anti-inflammatory activity can be explained by the presence of active flavonoids and cinnamic acid derivatives [ 119 , 120 , 135 , 136 , 137 , 138 ]. The former include acacetin, quercetin, and naringenin (terpenoid constituents may exert an addictive effect; the latter include CAPE and CA [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ,…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

“…This anti-inflammatory activity can be explained by the presence of active flavonoids and cinnamic acid derivatives [ 119 , 120 , 135 , 136 , 137 , 138 ]. The former include acacetin, quercetin, and naringenin (terpenoid constituents may exert an addictive effect; the latter include CAPE and CA [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ,…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

Allergic Inflammation: Effect of Propolis and Its Flavonoids

Oršolić

2022

Molecules

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The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views regarding the possible mechanisms and multiple benefits of flavonoids in combating allergy and allergy-related complications. These benefits arise from flavonoid anti-allergic, anti-inflammatory, antioxidative, and wound healing activities and their effects on microbe-immune system interactions in developing host responses to different allergens. Finally, this article presents various aspects of allergy pathobiology and possible molecular approaches in their treatment. Possible mechanisms regarding the antiallergic action of propolis on the microbiota of the digestive and respiratory tracts and skin diseases as a method to selectively remove allergenic molecules by the process of bacterial biotransformation are also reported.

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Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice

Cited by 9 publications

References 38 publications

Recent Update on the Anti-Inflammatory Activities of Propolis

Recent Update on the Anti-Inflammatory Activities of Propolis

Anti-Allergic Properties of Propolis: Evidence From Preclinical and Clinical Studies

Allergic Inflammation: Effect of Propolis and Its Flavonoids

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