Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-κB pathways

Stir-Fry Chicken with Green Curry Suppresses Inflammatory Gene Expression by Lipopolysaccharide-Induced Murine Macrophages

“…This effect was mediated through the inhibition of IB degradation and phosphorylation of p38 and Erk1/2 in part by decreased intracellular ROS. The same study also found that CAPE could rescue C57BL/6 mice from lethal LPS-induced septic shock while their serum TNF- and IL-1 also decreased [15]. Antioxidant activity of caffeic acid was also showed in t-butyl hydroperoxide-induced oxidative stress in U937 human monocytic cells by blocking glutathione depletion and inhibiting lipid peroxidation [16].…”

“…In addition, humans consuming instant coffee at 800 ml/day for 5 days decreased oxidative stress markers 8-isoprostaglandin F2α by 15.3% and 3-nitrotyrosine by 16.1% in urine [14]. Caffeic acid phenethyl ester (CAPE) has been shown to exhibit anti-inflammatory activity in vitro and in vivo [15]. A previous report indicated that CAPE inhibited LPS-induced NO and prostaglandin E2 (PGE 2 ) production and suppressed iNOS and COX-2 via blocking NF-B translocation and DNA-binding in LPS-stimulated RAW 264.7 cells.…”

Which one is more effective for the treatment of rat sepsis model: thalidomide or etanercept?

“…Thus, inhibiting TNF-α action using therapeutic agents decreases the infl ammatory response which is particularly useful in treatment of autoimmune diseases (16). For instance, Pascual et al reported TNF-α pathway inhibition by propolis, while Jung WK et al showed decreases in levels of TNF-α and IL-1β in the serum by CAPE treatment in lipopolysaccharide-induced septic shock model in mice (20,21). Another study showed strong inhibition of LPS-induced systemic infl ammatory responses known to be mediated by TNF-α as well as IL-6 and C-reactive protein release using etanercept, indicating effective inhibition of TNF-α activity by etanercept (22).…”

Evaluation of In-vitro Immunomodulatory Potential of Siddha formulation Naga Chendurum using Murine Macrophage RAW 264.7 Cell Line Model

“…IL-6 is a pivotal proinflammatory cytokine synthesized mainly by macrophages and plays a role in the acute-phaseinflammation response [6]. IL-1β is also considered to be another pivotal pro-inflammatory cytokine [7]. Naga Chendurum (NC) is a novel Siddha formulation comprised of a combination of herbs including Baptisia bracfeata, Eclipta prostrata, Madhuga longifolia and minerals such as zinc, sulphur, red orpiment etc.…”