Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats

Koltuksuz, Uğur; Özen, Süleyman; Uz, Efkan; Aydinç, Mustafa; Karaman, Abdurrahman; Gültek, Ahmet; Akyol, Ömer; Gürsoy, Murat; Aydın, Engin Nasuhi

doi:10.1016/s0022-3468(99)90103-3

Cited by 98 publications

(68 citation statements)

References 17 publications

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“…We thought that the reason of the death might be hemodynamic shock due to low blood pressure and HR. Oral CAPE administrations did not caused death (18).…”

Section: Discussionmentioning

confidence: 91%

“…In recent years, Natarajan et al (14) demonstrated that CAPE completely and specifically blocked the activation of nuclear transcription factor kappa B (NF-kB) and induced apoptosis; effects of inhibition of activation of NF-kB has been shown to account for the beneficial effect of this compound in a rat model of vascular injury (15). Moreover, CAPE has been shown to prevent ischemia reperfusion injury by means of a decreased NO level (16)(17)(18). Fadillioglu et al (19) shown that CAPE prevented doxorubicin induced cardiotoxicity and restored the blood pressure changes due to doxorubicin cardiotoxiticy.…”

Section: Introductionmentioning

confidence: 99%

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Dose Dependent Effects of Caffeic Acid Phenethyl Ester on Heart Rate and Blood Pressure in Rats

et al. 2005

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“…We thought that the reason of the death might be hemodynamic shock due to low blood pressure and HR. Oral CAPE administrations did not caused death (18).…”

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Dose Dependent Effects of Caffeic Acid Phenethyl Ester on Heart Rate and Blood Pressure in Rats

et al. 2005

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“…[7][8]19,20 It has been suggested that CAPE has protective effects against oxidative damage, which has been linked to its free radicalscavenging ability and anti-oxidant capacity. [20][21][22][23][24] Also, CAPE suppresses lipid peroxidation and inhibits lipoxygenase activity. 9,23,24 Pulmonary injury of radiation is well known and is accepted as a dose limiting factor in the treatment of the thoracic malignancy, such as heart, esophagus and breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of caffeic acid phenethyl ester on radiation induced lung injury in rats

Yildiz¹,

Soyuer²,

Saraymen³

et al. 2008

CIM

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Clin Invest Med 2008; 31 (5): E242-E247. AbstractPurpose: The prevention of radiation-induced pulmonary toxicity may help to improve radiation therapy in the cancer patient. The aim of this study was to investigate the pulmonary protective effects of caffeic acid phenethyl ester (CAPE), an antioxidant, on radiation-induced lung injury in rats. Methods:30 Wistar albino rats were divided into three groups and treated with saline, Radiation (RT) and RT + CAPE respectively. All rats were treated with CAPE (50 μmol/kg i.p.) or saline. The first dose of CAPE was injected 24 h before radiation and application continued daily, with radiation in second day and 2 days more after the radiation treatment. Radiation dose was 800 cGy for total body. At 72 hr after the last radiation application, under general anesthesia using ip ketamine, the lungs were removed immediately after decapitation. After sacrification, antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) activities and malondiadehyde (MDA) levels were evaluated in lung tissue. Results: The level of malondialdehyde (MDA) was higher in the RT group (233.4±1.5 nmol/g protein) than in both the control (131.8±0.92) and the RT + CAPE (151.4±1.8) groups (P < 0.001). However, CAT activity was decreased in the RT group (7.26±0.27 Umg protein) compared with control (8.49±0.51) and increased again in the RT + CAPE group (8.31±0.56; P<0.001). In accord with CAT activity, SOD activity in the RT group (0.42±0.07 nmolMDA/g wet tissue) was different from the control (0.78±0.02) and RT + CAPE (0.86±0.06) groups (P< 0.001). Conclusion: CAPE aplication with radiation therapy attenuated radiation induced pulmonary injury in vivo, possibly by its antioxidant effect.When radiation is absorbed by a biological material, free oxygen radicals are produced. The radicals are highly reactive molecules and, via chemical bonds that produce chemical changes, initiate a chain of events that result in biological damage. They can be produced either directly in the target molecule (usually DNA) or indirectly in other cellular molecules and they diffuse far enough to reach and damage critical targets. Most indirect effects occur by free radicals produced in water, since water makes up 70-80 % of mammalian cells. 1 In this way, chemotherapy and radiotherapy eliminate cancer cells, but their nonspecific targeting also destroys normal, healthy cells, particularly in epithelial tissues. Damage to the epithelium of the respiratory tract results in a pathologic condition known as pneumonitis . 2 Radiation (RT) is frequently used to treat tumors in and around the thorax. In these patients, RT-induced lung injury is common, occurring in 5% to 20% of patients with lung cancer. The incidence is somewhat less, 5% to 15%, for patients with tumors such as mediastinal lymphoma and breast cancer . 3 ORIGINAL RESEARCH

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“…It was demonstrated that administration of caffeic acid reduced oxidative stress by increasing antioxidant activities and decreasing oxidant status and lipid peroxidation in the intestine of rats in an experimental model of necrotizing enterocolitis (Tayman et al, 2011). Administration of caffeic acid has been also shown to completely block both the production of ROS from activated neutrophils and the XO system (Ma et al, 2006;Yildiz et al, 2009) and to protect intestinal tissues from ROS-mediated oxidative stress and reduce lipid peroxidation (Ek et al, 2008;Koltuksuz et al, 1999). Treatment of rats orally with caffeic acid resulted in a significant decrease in iron nitrilotriacetate-induced xanthine oxidase, lipid peroxidation, cglutamyl transpeptidase, and H 2 O 2 and there was a dose dependent and significant recovery of renal glutathione content and antioxidant enzymes (Rehman & Sultana, 2011).…”

Section: Reactive Oxygen and Nitrogen Speciesmentioning

confidence: 99%

Anti-Inflammatory Role of Natural Polyphenols and Their Degradation Products

Veres¹

2012

Severe Sepsis and Septic Shock - Understanding a Serious Killer

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Caffeic acid phenethyl ester prevents intestinal reperfusion injury in rats

Cited by 98 publications

References 17 publications

Dose Dependent Effects of Caffeic Acid Phenethyl Ester on Heart Rate and Blood Pressure in Rats

Dose Dependent Effects of Caffeic Acid Phenethyl Ester on Heart Rate and Blood Pressure in Rats

Protective effects of caffeic acid phenethyl ester on radiation induced lung injury in rats

Anti-Inflammatory Role of Natural Polyphenols and Their Degradation Products

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