Anti-Inflammatory Role of Natural Polyphenols and Their Degradation Products

Veres, Balázs

doi:10.5772/27889

Cited by 10 publications

(10 citation statements)

References 193 publications

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“…Phenolic acids have particularly demonstrated antioxidant and anti-inflammatory effects. 1,58 Indeed, the three derivatives of CGA identified in our study (3-CQA, 4-CQA, 5-CQA) have similar scavenging activity on O 2 − (from 30.1 to 37.0%). For instance, ROS induction could be inhibited by pre-treatment of granulocytes with chlorogenic acid from P. domestica.…”

Section: Comparison Between Varietiesmentioning

confidence: 52%

“…The differences in composition between varieties may be correlated with biological activities obtained. Phenolic acids have particularly demonstrated antioxidant and anti‐inflammatory effects . Indeed, the three derivatives of CGA identified in our study (3‐CQA, 4‐CQA, 5‐CQA) have similar scavenging activity on O 2 − (from 30.1 to 37.0%).…”

Section: Resultsmentioning

confidence: 99%

“…The family of flavonoids is known for its biological properties such as antioxidant activity, protein binding, anti‐inflammatory activity, antimicrobial activity and hyaluronidase inhibition. Quercetin is a well‐known flavonoid with strong antioxidant properties and anti‐inflammatory effects . At 0.1 mg mL −1 concentration, this compound can increase the longevity of Saccharomyces cerevisiae cells by 60% .…”

Section: Resultsmentioning

confidence: 99%

“…Quercetin is a well-known flavonoid with strong antioxidant properties and anti-inflammatory effects. 58 At 0.1 mg mL −1 concentration, this compound can increase the longevity of Saccharomyces cerevisiae cells by 60%. 59 Its derivatives such as isorhamnetin and rutin seem to have a similar resistance to oxidative stress, and other flavonoids such as kaempferol can prevent the accumulation of intracellular ROS.…”

Section: Comparison Between Varietiesmentioning

confidence: 99%

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Cosmetic potentials of Prunus domestica L. leaves

et al. 2017

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Section: Comparison Between Varietiesmentioning

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Comparison Between Varietiesmentioning

confidence: 99%

See 2 more Smart Citations

Cosmetic potentials of Prunus domestica L. leaves

et al. 2017

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“…Polyphenols have been shown to enhance epithelial barrier functions [55] and exert anti-inflammatory effects in inflamed human intestinal epithelium [56]. Polyphenols can exert their anti-inflammatory properties at multiple levels via modulation of MAPK, Akt, and NF- κ B signaling pathways, suppression of production of inflammatory cytokines and chemokines, inhibiting the activity of COX and iNOS, and attenuating production of ROS/RNS [57]. Taking the above information into consideration, it is conceivable that because of their higher antioxidant activity and polyphenol content, fermented preparations of RAM may also protect IECs against LPS insult through the inhibition of inflammatory responses.…”

Section: Discussionmentioning

confidence: 99%

Evaluation ofIn VitroAnti-Inflammatory Activities and Protective Effect of Fermented Preparations of Rhizoma Atractylodis Macrocephalae on Intestinal Barrier Function against Lipopolysaccharide Insult

Bose

Kim

2013

Evidence-Based Complementary and Alternative Medicine

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Lipopolysaccharide (LPS), a potent inducer of systemic inflammatory responses, is known to cause impairment of intestinal barrier function. Here, we evaluated the in vitro protective effect of an unfermented formulation of Rhizoma Atractylodis Macrocephalae (RAM), a traditional Chinese herbal medicine widely used in the treatment of many digestive and gastrointestinal disorders, and two fermented preparations of RAM, designated as FRAM-1 (prepared in Luria-Bertani broth) and FRAM-2 (prepared in glucose), on intestinal epithelial cells (IECs) against LPS insult. In general, fermented formulations, especially FRAM-2, but not unfermented RAM, exerted an appreciable protective effect on IECs against LPS-induced perturbation of membrane resistance and permeability. Both fermented formulations exhibited appreciable anti-inflammatory activities in terms of their ability to inhibit LPS-induced gene expression and induced production of a number of key inflammatory mediators and cytokines in RAW 264.7 macrophage cells. However, in most cases, FRAM-2 exhibited stronger anti-inflammatory effects than FRAM-1. Our findings also suggest that suppression of nuclear factor-κ β (NF-κ β) activity might be one of the possible mechanisms by which the fermented RAM exerts its anti-inflammatory effects. Collectively, our results highlight the benefits of using fermented products of RAM to protect against LPS-induced inflammatory insult and impairment in intestinal barrier function.

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PTEN over-expression by resveratrol in acute lymphoblastic leukemia cells along with suppression of AKT/PKB and ERK1/2 in genotoxic stress

et al. 2015

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The bioactive components of dietary phytochemicals are in the spotlight of research institutes, due to their significant antioxidant activities and health-promoting properties. Resveratrol is a polyphenol which is found abundantly in grapes and berries and has long been known as a chemo-preventive agent. The main purpose of this study was to provide a new mechanistic insight into the growth inhibition of acute lymphoblastic leukemia cells by resveratrol along with a DNA damage agent. It was found that the treatment of pre-B ALL cells by resveratrol in the presence or absence of doxorubicin resulted in decreased cell viability and a synergistic increase in cytotoxicity. Cell death was accompanied by a significant increase in phosphorylated p53 at serine 15 and accumulation of PTEN. In addition, resveratrol inhibited the over-expression of p-AKT and p-ERK1/2. These findings clearly demonstrated that resveratrol and doxorubicin synergistically increase the cytotoxicity of pre-B ALL cells via the hyper-activation of two important tumor suppressor proteins and two major signal transduction pathways.

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Anti-Inflammatory Role of Natural Polyphenols and Their Degradation Products

Cited by 10 publications

References 193 publications

Cosmetic potentials of Prunus domestica L. leaves

Cosmetic potentials of Prunus domestica L. leaves

Evaluation ofIn VitroAnti-Inflammatory Activities and Protective Effect of Fermented Preparations of Rhizoma Atractylodis Macrocephalae on Intestinal Barrier Function against Lipopolysaccharide Insult

PTEN over-expression by resveratrol in acute lymphoblastic leukemia cells along with suppression of AKT/PKB and ERK1/2 in genotoxic stress

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