Caffeic acid phenethyl ester (CAPE) protects rat skeletal muscle against ischemia–reperfusion-induced oxidative stress

Özyurt, Hüseyın; Ozyurt, Birsen; Koca, Kenan; Özgöçmen, Salih

doi:10.1016/j.vph.2007.04.008

Cited by 62 publications

(57 citation statements)

References 26 publications

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“…The increases in these antioxidant enzymes in Naringin-supplemented I/R group may be due to the facilitating effect of Naringin in the stimulation of the expression of the antioxidant enzymes due to increased formation of ROS during reperfusion period after ischemia. Thus, similar to the Ozyurt et al's findings, these compensatory increases in the antioxidant enzyme activities in Naringin-supplemented group would have decreased the oxidative stress due to I/R injury 63 . LDH (E.C.…”

Section: Discussionsupporting

confidence: 81%

“…Rajadural and coworkers have reported that Naringin increased SOD and CAT activities 62 . Similarly, Ozyurt and coworkers have proved that caffeic acid phenethyl ester (CAPE) protect rat skeletal muscle and enhanced SOD and CAT activities against I/R-induced oxidative stress 63 . As the lower SOD activity compared with the control group was reported in 6-h ischemia and 4-h reperfusion of hindlimb tourniquet model 64 .…”

Section: Discussionmentioning

confidence: 96%

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Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats

Gürsul

Akdemir

Akkoyun

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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This study was designed to investigate the antioxidant effects of Naringin, in ischemia/ reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p50.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p50.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p50.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 96%

Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats

Gürsul

Akdemir

Akkoyun

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…TOS indicates the total oxidative products in tissue. Oxidative products such as ROS, reactive nitrogen species, hydrochloric acid, malondialdehyde, and lipid peroxides constitute TOS (11). In our study, TOS levels signifi cantly increased after aortic I/R.…”

Section: Discussionsupporting

confidence: 50%

Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion

Gl¹,

Kirişçi²,

Dursun³

et al. 2013

BLL

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Abstract:Purpose: The aim of this study was to investigate the effects of adrenomedullin (AM) and vascular endothelial growth factor (VEGF) on lung injury as a remote organ following skeletal muscle ischemia-reperfusion injury in a rat model. Materials and methods: Thirty-six Wistar rats were randomized into six groups (n=6). Laparotomy was performed in all groups under general anesthesia. Nothing else was done in Group S (Sham). Ischemia reperfusion group (Group I/R) underwent ischemia and reperfusion performed by clamping and declamping of the infrarenal abdominal aorta for 120 minutes, respectively. Group VEGF and Group AM received intravenous infusion of VEGF (0.8 μg/kg) or AM (12 μg /kg) respectively, without ischemia and reperfusion. Group IR+VEGF and Group IR+AM received intravenous infusion of VEGF (0.8 μg/kg) or AM (12 μg /kg) respectively immediately after 2 hours period of ischemia. At the end of reperfusion period. Lung tissue samples were taken for biochemical examination. Total oxidant status (TOS) and total antioxidant status (TAS) levels in lung tissue were determined by using a novel automated method. p<0.05 was considered as statistically signifi cant. Results: TOS levels were signifi cantly higher in Group I/R, when compared with groups S, AM and VEGF (p=0.004, p=0.011, p=0.017, respectively) and signifi cantly lower in groups I/R+AM and I/R+VEGF, when compared with Group I/R (p=0.018, p=0.006, respectively). TAS levels were signifi cantly higher in Group I/R, when compared with groups S, AM and VEGF (p=0.006 p=0.016, p=0.016, respectively) and signifi cantly lower in Group I/R+AM, when compared with Group I/R (p=0.016). Conclusion: These fi ndings indicate that AM and VEGF acted effectively on the prevention of lung injury induced by skeletal muscle ischemia-reperfusion injury in a rat model (Fig. 2, Ref. 30). Full Text in PDF www.elis.sk.

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“…Previous studies have shown that oxidative damage was attenuated by EA and HES after I/R in animals 64,66,67 . Several studies have reported various antioxidants that can reduce the tissue MDA level 1 . The intestinal ischemia reperfusion study has reported a significant decrease of MDA level in EA group 67 .…”

Section: Resultsmentioning

confidence: 99%

“…It is quite an important clinical condition, which includes a large spectrum of vascular events such as organ transplantation, thrombolytic therapy, limb trauma and cardiovascular surgery. Ischemia/Reperfusion (I/R) affects many different organs such as the brain, heart, lung and skeletal muscle in varying degrees 1 . Skeletal muscle I/R can start numerous detrimental events in tissue such as release and production of oxygen-derived radicals by the cells when exposed to ischemia, degradation of phospholipids by peroxidation, damage in endothelial and parenchymal cells, cytosolic calcium overload and edema due to increased permeability in the microcirculation 2 .…”

Section: Introductionmentioning

confidence: 99%

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

Akdemir

Gülçın

Karagöz

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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The antioxidant effects of ellagic acid (EA) and hesperidin (HES) against skeletal muscle ischemia/reperfusion injury (I/R) were performed. Hindlimb ischemia has been induced by tourniquet occlusion for 2 h on left hindlimb. At the end of ischemia, the tourniquate has been removed and initiated reperfusion for 2 h. EA (100 mg/kg) has been applied orally before ischemia/reperfusion in the EA + I/R group. HES (100 mg/kg) has been given orally in the HES + I/R group. The left gastrocnemius muscle has been harvested and stored immediately at À80 C until assessed for the levels of MDA and antioxidant enzymes activities. MDA level has statistically increased in I/R group (p50.05) compared to other groups. The muscle tissue antioxidant enzymes activities were lower than the other groups in the I/R group (p50.05). EA and HES treatments significantly reversed the damage level in I/R, also activity of tissue SOD increased in the EA + I/R and HES + I/R groups.

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Caffeic acid phenethyl ester (CAPE) protects rat skeletal muscle against ischemia–reperfusion-induced oxidative stress

Cited by 62 publications

References 26 publications

Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats

Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats

Antioxidative effects of adrenomedullin and vascular endothelial growth factor on lung injury induced by skeletal muscle ischemia-reperfusion

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

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