Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma

Jung, Won‐Kyo; Lee, Da-Young; Choi, Yung Hyun; Yea, Sung Su; Choi, Inhak; Park, Sae-Gwang; Seo, Su‐Kil; Lee, Soo-Woong; Lee, Chang-Min; Kim, Se‐Kwon; Jeon, You‐Jin; Choi, Il‐Whan

doi:10.1016/j.lfs.2008.01.014

Cited by 78 publications

(58 citation statements)

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“…Human mast cells (HMC-1) are useful cells in the study of immediate-type hypersensitivity because they secrete histamine and many inflammatory cytokines, but only when stimulated with phorbol esters and calcium ionophore A23187 (Kim et al, 2007). Although CAPE has been shown to exhibit anti-allergic effects, its cellular mechanism in mast cells is unknown (Jung et al, 2008;Nader, 2013;Park et al, 2008;Yang, 2011). The purpose of this study was to identify whether CAPE could regulate the signal transduction pathways and the inflammatory mediators, either released or synthesized by the PMACIinduced mast cells.…”

Section: Discussionmentioning

confidence: 99%

Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells

Cho

Park

Jung

et al. 2014

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 99%

Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells

Cho

Park

Jung

et al. 2014

Pharmaceutical Biology

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“…Episodic airway obstruction and airway inflammation are two features of bronchial asthma (1). While the exact etiology of asthma remains unknown, it is involved in possible genetic predispositions coupled with an exposure to 'inflammatory triggers' and 'bronchospastic triggers' (2). Based on clinical manifestations, the principles of pharmacotherapy are mainly centered on the reversal or prevention of bronchial smooth muscle constriction and the reversal or prevention of airway inflammation following asthmatic seizures.…”

Section: Introductionmentioning

confidence: 99%

Stereoselective activity of 2-(4-amino-3-chloro-5- trifluomethyl-phenyl)-2-tert-butylamino-ethanol hydrochloride to improve the pulmonary function in asthma

Pan

et al. 2014

Biomedical Reports

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Abstract. Asthma is a chronic airway disease that is characterized by significantly exacerbated bronchospasms and marked inflammation of the airways. Although the etiology of asthma remains to be determined, genetic predisposition is one of the factors involved. β 2 -agonists compounds may serve as options for the treatment of bronchial asthma. The aim of the present study was to investigate the effects of 2-(4-amino-3-chloro-5-t rifluomethyl-phenyl)-2-tert-butylamino-ethanol hydrochloride (SPFF) and its enantiomers with regard to improving asthmatic pulmonary function and selective binding to β 2 -adrenergic receptor. The bronchoconstrictor action of histamine in guinea pigs was conducted and the results demonstrated that (-)SPFF and (±)SPFF could significantly inhibit the increase of bronchoconstriction induced by histamine, while (+)SPFF did not show an effect. Inflammatory mediator release from allergic lung tissues was determined and it was found that (±)SPFF showed the highest activity among all the tested compounds, while the efficacy of (-)SPFF was similar to that of (+)SPFF. SPFF and its enantiomers stimulated cyclic adenosine monophosphate (cAMP) production in the asthmatic lung tissues examined, showing that asthmatic lung tissues had a significant cAMP enhancement in response to (-)SPFF and (±)SPFF compared with (+)SPFF. Cardiac contractility of the right atria was assessed in the guinea pigs to establish the receptor selectivity of the compounds. The results indicated that all the compounds had high affinities to the β 2 receptor. In conclusion, with regards to asthmatic pulmonary function improvement, (-)SPFF was more efficient as compared to (+) SPFF, while no significant difference was observed for the receptor selectivity of (-)SPFF and (+)SPFF.

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“…7,9 In another study, caffeic acid phenyl ester (CAPE) was also considered as possible antiallergic component. 10,11 Malaysia and Brazilian propolis both contain flavonoids prompting the researcher to use these propolis and also Indonesian propolis, in which there are fewer publications regarding its components and composition to determine the use of propolis as an anti-allergic.…”

Section: Introductionmentioning

confidence: 99%

Propolis as an Anti-allergy Based on Decrease in Total Eosinophil Count in Rat Models

Nambiar¹,

Rohmawaty²,

Lismayanti³

2015

amj

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Background: Propolis is a natural herb derived from plant resins by bees. Propolis contains flavonoids that act as anti-allergy. The composition of flavonoids in propolis varies according to each region like Brazilian, Chinese, Malaysian and Indonesian propolis due to differences in medicinal plants in that area. The aim of this study is to determine the effect of propolis as an anti-allergy and to determine which is the most effective among propolis of Brazilian, Malaysian and Indonesian origin. Methods: An experimental study was performed on 28 Wistar male rats divided into four groups, Brazilian, Malaysian, Indonesian propolis and a negative control group. The used parameter was decreased in total eosinophil count in ovalbumin induced allergy in rats. Propolis or aquadest as control were given orally 0.25ml once daily. Results: All three groups of propolis showed statistically significant results (p<0.05), in decreasing eosinophil count. However, Malaysian and Brazilian propolis showed much more significant effects compared to that of Indonesian propolis. This could be due to the difference in composition and concentration of flavonoids in Indonesian propolis compared to the Brazilian and Malaysian propolis. Conclusion:Propolis has a significant effect as an anti-allergy. Malaysian and Brazilian propolis are more effective as an anti-allergy compare to Indonesian propolis. Propolis can thus be used as an alternative treatment for allergy. [AMJ.2015;2(1):208-12]

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Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma

Cited by 78 publications

References 50 publications

Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells

Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells

Stereoselective activity of 2-(4-amino-3-chloro-5- trifluomethyl-phenyl)-2-tert-butylamino-ethanol hydrochloride to improve the pulmonary function in asthma

Propolis as an Anti-allergy Based on Decrease in Total Eosinophil Count in Rat Models

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