Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells

Cho, Mi Suk; Park, Won Sun; Jung, Won-Kyo; Qian, Zhong‐Ji; Lee, Daesung; Choi, Jungsik; Lee, Da-Young; Park, Sae-Gwang; Seo, Su‐Kil; Kim, Hak-Ju; Won, Jun Yeon; Yu, Byeng Chul; Choi, Il‐Whan

doi:10.3109/13880209.2013.865243

Cited by 64 publications

(50 citation statements)

References 32 publications

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“…Flavonoids and caffeic acid also aid the immune system by promoting phagocytic activities and stimulating cellular immunity. 7,23,24,25 During the inflammatory reaction, activated macrophages will produce TNF-α, IL-1, IL-6, IL-10, chemokines, and short-lived lipid mediators to orchestrate a local inflammation. 26 Studies have shown significant increase in TNF-α and IL-1 in irreversible pulpitis.…”

Section: Discussionmentioning

confidence: 99%

Effects of MTA and Brazilian propolis on the biological properties of dental pulp cells

2019

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The aim of this study was to evaluate the effect of mineral trioxide aggregate (MTA) and Brazilian propolis on the cell viability, mineralization, anti-inflammatory ability, and migration of human dental pulp cells (hDPCs). The cell viability was evaluated with CCK-8 kit after 1, 5, 7, and 9 days. The deposition of calcified matrix and the expression of osteogenesis-related genes were evaluated by Alizarin Red staining and real-time PCR after incubation in osteogenic medium for 21 days. The expression of inflammation-related genes in cells was determined after exposure to 1 μg/mL LPS for 3 h. Finally, the numbers of cells that migrated through the permeable membranes were compared during 15 h. Propolis and MTA significantly increased the viability of hDPCscompared to the control group on days 7 and 9. In the propolis group, significant enhancement of osteogenic potential and suppressed expression of IL-1β and IL-6 was observed after LPS exposure compared to the MTA and control groups. The number of migration cells in the propolis group was similar to that of the control group, while MTA significantly promoted cell migration. Propolis showed comparable cell viability to that of MTA and exhibited significantly higher anti-inflammatory and mineralization promotion effects on hDPCs.

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Section: Discussionmentioning

confidence: 99%

Effects of MTA and Brazilian propolis on the biological properties of dental pulp cells

2019

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“…CAPE is considered a particularly strong anti-inflammatory constituent, able to specifically target NF-κB signaling (Armutcu et al, 2015). This compound has been also found to modulate ERK MAPK signaling in T cells and mastocytes (Cho et al, 2014), and to regulate PI3K/Akt pathway in different human cell lines (Li et al, 2017). Possible downstream effects of these anti-inflammatory mechanisms may include the downregulation of key inflammatory enzymes, like xanthine oxidase, cyclooxygenase, matrix metalloproteinases, and inducible nitric oxide synthase (Armutcu et al, 2015; Li et al, 2017).…”

Section: Propolismentioning

confidence: 99%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.

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“…Among the inflammatory mediators released from mast cells, histamine is known to be the most well-characterized mediator implicated in the acute phase of hypersensitivity, including anaphylactic shock (30). To determine whether BV inhibits histamine release in the culture medium from mast cells, the PMAcI-induced histamine release was measured.…”

Section: Resultsmentioning

confidence: 99%

Inhibitory effects of bee venom on mast cell-mediated allergic inflammatory responses

et al. 2018

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Although bee venom (BV) is a toxin that causes bee stings to be painful, it has been widely used clinically for the treatment of certain immune‑associated diseases. BV has been used traditionally for the treatment of chronic inflammatory diseases. In this regard, the present study analyzed the effect of BV on the regulation of inflammatory mediator production by mast cells and their allergic inflammatory responses in an animal model. HMC‑1 cells were treated with BV prior to stimulation with phorbol‑12‑myristate 13‑acetate plus calcium ionophore A23187 (PMACI). The production of allergy‑associated pro‑inflammatory mediators was examined, and the underlying mechanisms were investigated. Furthermore, to investigate whether BV exhibits anti‑inflammatory effects associated with anti‑allergic effects in vivo, a compound 48/80‑induced anaphylaxis model was used. BV inhibited histamine release, mRNA expression and production of cytokines in the PMACI‑stimulated HMC‑1 cells. Furthermore, the inhibitory effects of BV on mitogen‑activated protein kinase (MAPK), MAPK kinase, signal transducer and activator of transcription 3 (STAT3) and Akt were demonstrated. The present study also investigated the ability of BV to inhibit compound 48/80‑induced systemic anaphylaxis in vivo. BV protected the mice against compound 48/80‑induced anaphylactic‑associated mortality. Furthermore, BV suppressed the mRNA expression levels of pro‑inflammatory cytokines, and suppressed the activation of MAPK and STAT3 in this model. These results provide novel insights into the possible role of BV as a modulator for mast cell‑mediated allergic inflammatory disorders.

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Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells

Cited by 64 publications

References 32 publications

Effects of MTA and Brazilian propolis on the biological properties of dental pulp cells

Effects of MTA and Brazilian propolis on the biological properties of dental pulp cells

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

Inhibitory effects of bee venom on mast cell-mediated allergic inflammatory responses

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