Caduet enhances connexin 43 phosphorylation in left ventricular and thoracic aorta of SH model rats

Huang, Xiaoyan; Yang, Junlu; Song, Baoguo; Wang, Nana; Ma, Meijuan; Wang, Haifang; Wang, Sha; Hao, Shuangping; Cheng, Gong

doi:10.3892/etm.2020.9207

Cited by 3 publications

(2 citation statements)

References 33 publications

(33 reference statements)

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“…The levels of TG and TC in the SHR group notably increased compared to the WKY group. These results are consistent with the research findings that the TG and TC levels were higher in SHRs than in WKY rats [ 29 , 30 ]. In contrast, the TG and TC levels in the FE250 and FE500 groups notably decreased compared with those in the SHR group.…”

Section: Resultssupporting

confidence: 93%

Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

et al. 2021

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Finger millet (Eleusine coracana) contains high levels of calcium and polyphenols, which have a variety of beneficial functions. We tested the hypothesis that finger millet ethanol extracts (FEs) have an antihypertensive effect in spontaneously hypertensive rats (SHRs). The study groups were assigned as follows: (1) Wistar Kyoto rats (normal); (2) SHRs treated with saline (negative control); (3) SHRs treated with captopril 50 mg/kg bw (positive control); (4) SHRs treated with FE 250 mg/kg bw (FE250); and (5) SHRs treated with FE 500 mg/kg bw (FE500). FE supplementation improved the lipid profiles, including the triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, without deterioration in liver function. The thiobarbituric acid reactive substance concentration and superoxide dismutase activity significantly improved after the application of FE250 and FE500. Interestingly, FE250 and FE500 application dramatically reduced the systolic blood pressure. FE supplementation exhibited powerful control over the renin-angiotensin system by reducing the angiotensin-converting enzyme levels and renin mRNA expression in the kidney. Additionally, FE500 application ameliorated vascular remodeling, reversed the thickening media, and decreased the media thickness/lumen diameter ratio of the aorta. These results imply that FEs are a potent antihypertensive nutraceutical for regulating the renin–angiotensin system and simultaneously inhibiting oxidative stress.

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Section: Resultssupporting

confidence: 93%

Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

et al. 2021

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“…Prolonged elevation in blood pressure initiates a cascade of physiological changes, including vascular endothelial damage, abnormal proliferation, migration, invasion and phenotypic transformation of vascular smooth muscle cells (VSMCs). These processes eventually cause endothelial dysfunction, blood vessel constriction and stiffness, ultimately, insufficient blood supply to crucial organs like the heart, kidney and brain (Fang et al, 2019;Dikalova et al, 2020;Huang et al, 2020). Consequently, hypertension becomes a significant risk factor for the development of cardio-and cerebro-vascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram for predicting all-cause mortality in American adult hypertensive populations

Yang,

Shen,

Seyiti

et al. 2023

Front. Pharmacol.

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Backgrounds: Hypertension stands as the predominant global cause of mortality. A notable deficiency exists in terms of predictive models for mortality among individuals with hypertension. We aim to devise an effective nomogram model that possesses the capability to forecast all-cause mortality within hypertensive populations.Methods: The data for this study were drawn from nine successive cycles of the National Health and Nutrition Examination Survey (NHANES) spanning the years from 1999 to 2016. The dataset was partitioned into training and validation sets at a 7:3 ratio. We opted for clinical practice-relevant indicators, applied the least absolute shrinkage and selection operator (LASSO) regression to identify the most pertinent variables, and subsequently built a nomogram model. We also employed concordance index, receiver operating characteristic (ROC) curves, calibration curves and decision curve analysis (DCA) to assess the model’s validity.Results: A total of 17,125 hypertensive participants were included in this study with a division into a training set (11,993 individuals) and a validation set (5,132 individuals). LASSO regression was applied for the training set to obtain nine variables including age, monocytes, neutrophils, serum albumin, serum potassium, cardiovascular disease, diabetes, serum creatinine and glycated hemoglobin (HbA1C), and constructed a nomogram prediction model. To validate this model, data from the training and validation sets were used for validation separately. The concordance index of the nomogram model was 0.800 (95% CI, 0.792–0.808, p < 0.001) based on the training set and 0.793 (95% CI, 0.781–0.805, p < 0.001) based on the validation set. The ROC curves, calibration curves, and DCA curves all showed good predictive performance.Conclusion: We have developed a nomogram that effectively forecasts the risk of all-cause mortality among American adults in hypertensive populations. Clinicians may use this nomogram to assess patient’s prognosis and choose a proper intervention in a timely manner.

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A systematic review and meta-analyses on the effects of atorvastatin on blood pressure and heart rate

Costa

Julião-Silva

Belo

et al. 2022

European Heart Journal - Cardiovascular Pharmacotherapy

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AIMS: Considering the inconsistencies in the literature on the atorvastatin effect on blood pressure (BP), we performed these meta-analyses. METHODS AND RESULTS: Through a search of the EMBASE, PubMed and Web of Science databases, 1412 articles were identified, from which 33 randomized clinical trials (RCT) and 44 pre-clinical were selected. Populations from RCT were stratified according to baseline BP and lipid levels. We performed meta-analyses of the effect of atorvastatin on systolic (SBP), diastolic and mean BP; heart rate (HR); HR variability and baroreflex. Atorvastatin reduced SBP in the overall population (P = 0.05 vs. placebo; P = 0.03 vs. baseline), in normotensive and hyperlipidaemic (P = 0.04 vs. placebo; P = 0.0001 vs. baseline) and in hypertensive and hyperlipidaemic (P = 0.02 vs. placebo; P = 0.008 vs. baseline) individuals in parallel RCT, but it did not affect SBP in normotensive and normolipidemic individuals (P = 0.51 vs. placebo; P = 0.46 vs. baseline). Although an effect of atorvastatin was detected in hyperlipidaemic individuals, the meta-regression coefficient for the association of LDL-cholesterol reduction with SBP reduction in the overall population demonstrated that SBP reduction is not dependent on the changes in LDL-cholesterol. A meta-analysis of preclinical reports demonstrated that SBP was reduced in atorvastatin-treated hypertensive and normolipidemic rats [spontaneously hypertensive rats: P<0.00001], but not in normotensive and normolipidemic rats (control rats: P = 0.97). Atorvastatin also reduced the HR in spontaneously hypertensive rat. CONCLUSION: Atorvastatin lowers blood pressure independent of LDL-cholesterol levels. Additional studies are needed to estimate the involvement of the autonomic nervous system in the blood-pressure-lowering effect of atorvastatin.

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Caduet enhances connexin 43 phosphorylation in left ventricular and thoracic aorta of SH model rats

Cited by 3 publications

References 33 publications

Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

Finger Millet Ethanol Extracts Prevent Hypertension by Inhibiting the Angiotensin-Converting Enzyme Level and Enhancing the Antioxidant Capacity in Spontaneously Hypertensive Rats

Development and validation of a nomogram for predicting all-cause mortality in American adult hypertensive populations

A systematic review and meta-analyses on the effects of atorvastatin on blood pressure and heart rate

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