A systematic review and meta-analyses on the effects of atorvastatin on blood pressure and heart rate

Costa, Gabriel Salerno; Julião-Silva, Letícia São; Belo, Viní­cius Silva; Oliveira, Helena Coutinho Franco de; Chaves, Valéria Ernestânia

doi:10.1093/ehjcvp/pvac053

Cited by 3 publications

(2 citation statements)

References 96 publications

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“…This was also confirmed by our findings, where we observed a –1.26‐mmHg reduction in DBP; p < .05 (Figure 5). In addition, similar findings were observed by Costa and colleagues, they demonstrated that atorvastatin was significant in BP reduction independent of LDL profiles 69 . This BP lowering effect of atorvastatin was observed in our study, and atorvastatin was able to significantly reduce the levels of SBP and DBP ( p < .05) (Figures 3 and 5).…”

Section: Discussionsupporting

confidence: 92%

“…In addition, similar findings were observed by Costa and colleagues, they demonstrated that atorvastatin was significant in BP reduction independent of LDL profiles. 69 This BP lowering effect of atorvastatin was observed in our study, and atorvastatin was able to significantly reduce the levels of SBP and DBP (p < .05) (Figures 3 and 5). Along with other known statins, our analysis also studies rosuvastatin, which has been shown to significantly improve BP in patients with hypertension.…”

Section: Discussionsupporting

confidence: 78%

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Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials

Liu

Deng

et al. 2023

J of Clinical Hypertension

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Statins have been proven to be effective in minimizing the risk of cardiovascular adverse events, however, their effect on BP variability is debatable with respect to their significance and their use as a potential anti‐hypertensive. Using a meta‐analysis approach, the aim of this study was to explore whether certain statins have the potential to lower blood pressure (BP). For the period 2002–2022, Scopus, PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials databases were searched for the studies that examined the effect of statins on blood pressure in normotensive or hypertensive individuals. Randomized controlled clinical trials that investigated this effect were included based on our inclusion criteria. Our primary outcomes were changes in systolic and diastolic blood pressure (DBP). The final analysis of the study included 49 RCTs involving 45 173 participants randomized to receive either statins or placebo. Among the two groups, the total weighted mean difference (WMD) for systolic blood pressure (ΔSBP) was –1.42 (95% CI: –2.38, –0.46; p = .004) and diastolic blood pressure (ΔDBP) was 0.82 (95% CI: –1.28, –0.36; p = .0005). Despite various studies suggesting the efficacy of statins in blood pressure lowering to be significant and non‐significant both, we observed a decrease in SBP and DBP both, although the change was not as large and could be considered significant. A large multicenter, multi‐ethnic, large sample pool size, and a long period follow‐up study is still required to assert these claims.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 78%

Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials

Liu

Deng

et al. 2023

J of Clinical Hypertension

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DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE−/− mice via suppressing inflammation, endothelial necroptosis and apoptosis

Liu

et al. 2023

European Journal of Pharmacology

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A Survey on Big Data Application for Modality and Physiological Signal Analysis

Qinghui¹

2022

AIST

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An explosion of healthcare data has occurred in recent years due to the widespread availability of sophisticated physiological signal monitoring devices and the development of telemetry and cognitive communication systems. Additionally, the accessibility of medical data for the establishment of applications in big data has rapidly increased due to affordable and efficient storage and power techniques. With the current state of technology, healthcare professionals are unable to effectively handle and understand large, rapidly changing, and complex data; this is where big data applications come in. Making medical services more cost- effective and sustainable is a driving force behind the creation of such systems. In this article, we present a discussion of the present condition of big data applications that make use of physiological signals or derived metrics to aid in medical decision making in the home and in the hospital. Specifically, we examine critical care systems designed for continuous healthcare management and address the obstacles that must be surmounted before such systems may be used in real-world practice. Big data technologies might revolutionize future hospital administration if these problems are solved.

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A systematic review and meta-analyses on the effects of atorvastatin on blood pressure and heart rate

Cited by 3 publications

References 96 publications

Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials

Statin's role on blood pressure levels: Meta‐analysis based on randomized controlled trials

DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE−/− mice via suppressing inflammation, endothelial necroptosis and apoptosis

A Survey on Big Data Application for Modality and Physiological Signal Analysis

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