Cadmium tissue level in women diagnosed with breast cancer – A case control study

Anđelković, Milena; Djordjević, Aleksandra Buha; Miljaković, Evica Antonijević; Javorac, Dragana; Čolaković, Nataša; Oprić, Svetlana; Petricevic, Simona; Granić, Miroslav; Kotur‐Stevuljević, Jelena; Antonijević, Biljana; Bulat, Zorica

doi:10.1016/j.envres.2021.111300

Cited by 27 publications

(20 citation statements)

References 54 publications

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“…Interest in the role of Cd as a toxic metal ubiquitously present in the environment has risen during the last decades, especially with the reference to its possible role in various human diseases, especially carcinomas (Anđelković et al 2021;Buha et al 2018Buha et al , 2019Buha et al , 2020. Its possible role in PDAC has been recently reviewed by Buha et al (2017) suggesting multiple mechanisms responsible for Cd actions leading to the development of PDAC.…”

Section: Introductionmentioning

confidence: 99%

Role of microRNAs in response to cadmium chloride in pancreatic ductal adenocarcinoma

Mortoglou

Djordjević

et al. 2021

Arch Toxicol

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal and aggressive malignancies with a 5-year survival rate less than 9%. Early detection is particularly difficult due to the lack of symptoms even in advanced stages. microRNAs (miRs/miRNAs) are small (~ 18–24 nucleotides), endogenous, non-coding RNAs, which are involved in the pathogenesis of several malignancies including PDAC. Alterations of miR expressions can lead to apoptosis, angiogenesis, and metastasis. The role of environmental pollutants such as cadmium (Cd) in PDAC has been suggested but not fully understood. This study underlines the role of miRs (miR-221, miR-155, miR-126) in response to cadmium chloride (CdCl2) in vitro. Lethal concentration (LC50) values for CdCl2 resulted in a toxicity series of AsPC-1 > HPNE > BxPC-3 > Panc-1 = Panc-10.5. Following the treatment with CdCl2, miR-221 and miR-155 were significantly overexpressed, whereas miR-126 was downregulated. An increase in epithelial–mesenchymal transition (EMT) via the dysregulation of mesenchymal markers such as Wnt-11, E-cadherin, Snail, and Zeb1 was also observed. Hence, this study has provided evidence to suggest that the environmental pollutant Cd can have a significant role in the development of PDAC, suggesting a significant correlation between miRs and Cd exposure during PDAC progression. Further studies are needed to investigate the precise role of miRs in PDAC progression as well as the role of Cd and other environmental pollutants.

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Section: Introductionmentioning

confidence: 99%

Role of microRNAs in response to cadmium chloride in pancreatic ductal adenocarcinoma

Mortoglou

Djordjević

et al. 2021

Arch Toxicol

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“…A similar concern regarding using toenails was made years ago by Vinceti et al (2007) when assessing the relationship between Cd content and prostate cancer in humans [ 70 ]. Furthermore, several recent studies tend to consider agent content at cancer sites rather than in other tissues [ 71 , 72 , 73 ]. Several studies have identified that Ni content in PDAC tissue is a reliable biomarker across different studies [ 67 , 74 , 75 ], while our results also suggest that Ni could be involved in PDAC development in humans.…”

Section: Discussionmentioning

confidence: 99%

Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs

Mortoglou

Manić

Djordjevic

et al. 2022

Toxics

Self Cite

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Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types with a limited overall survival rate due to the asymptomatic progression of symptoms in metastatic stages of the malignancy and the lack of an early reliable diagnostic biomarker. MicroRNAs (miRs/miRNAs) are small (~18–24 nucleotides), endogenous, non-coding RNAs, which are closely linked to the development of numerous malignancies comprising PDAC. Recent studies have described the role of environmental pollutants such as nickel (Ni) in PDAC, but the mechanisms of Ni-mediated toxicity in cancer are still not completely understood. Specifically, Ni has been found to alter the expression and function of miRs in several malignancies, leading to changes in target gene expression. In this study, we found that levels of Ni were significantly higher in cancerous tissue, thus implicating Ni in pancreatic carcinogenesis. Hence, in vitro studies followed by using both normal and pancreatic tumor cell lines and increasing Ni concentration increased lethality. Comparing LC50 values, Ni-acetate groups demonstrated lower values needed than in NiCl2 groups, suggesting greater Ni-acetate. Panc-10.05 cell line appeared the most sensitive to Ni compounds. Exposure to Ni-acetate resulted in an increased phospho-AKT, and decreased FOXO1 expression in Panc-10.05 cells, while NiCl2 also increased PTEN expression in Panc-10.05 cells. Specifically, following NiCl2 exposure to PDAC cells, the expression levels of miR-221 and miR-155 were significantly upregulated, while the expression levels of miR-126 were significantly decreased. Hence, our study has suggested pilot insights to indicate that the environmental pollutant Ni plays an important role in the progression of PDAC by promoting an association between miRs and Ni exposure during PDAC pathogenesis.

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“…Epidemiological studies also indicated that urinary Cd levels were higher in breast cancer patients than normal controls (McElroy et al, 2006;Nagata et al, 2013), while breast cancer tissue had four times higher Cd levels than surrounding healthy tissue. (Andelkovic et al, 2021) The major strength of our study is the use of geographically weighted regression models, which is able to detect spatially varied magnitude of the associations and provide insight into priority regions for health resource planning and allocation. Moreover, we had access to a variety of data on socioeconomic factors and soil heavy metals, allowing us to explore the potential in uencing factors.…”

Section: Discussionmentioning

confidence: 99%

“…Then, we selected statistically signi cant socioeconomic variables in multivariable model, and incorporated each of soli heavy metal pollutants into the model, separately. (Andelkovic et al, 2021) This implementation allowed a global assessment of the existence of relationships, as well as their directions, between the different covariates and the rate of breast cancer hospitalization in women before analyzing the effect of the association by county.…”

Section: Spatial Autocorrelation Analysismentioning

confidence: 99%

Spatial patterns and the associated factors for breast cancer hospitalization in Fujian Province, China

Song

Huang

Wei

et al. 2022

Preprint

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Despite the known increasing incidence of breast cancer in China, evidence on the spatial pattern of hospitalization for breast cancer is scarce. This study aimed to describe the disparity of breast cancer hospitalization in Southeast China and to explore the impacts from socioeconomic factors and heavy metal pollution in soil. This study was conducted using the New Rural Cooperative Medical Scheme (NRCMS) claims data covering 25.52 million female rural residents from 73 counties in Southeast China during 2015–2016. The associations between breast cancer hospitalization and socioeconomic factors and soil heavy metals pollutants were evaluated with quasi-Poisson regression models and geographically weighted Poisson regressions (GWPR).The annual hospitalization rate for breast cancer was 101.40/100,000 in the studied area and the rate varied across different counties. Overall, hospitalization for breast cancer was associated with road density (β = 0.43, P = 0.02), urbanization (β = 0.02, P = 0.002) and soil cadmium (Cd) pollution (β = 0.01, P = 0.02). In the GWPR model, a stronger spatial association of Cd, road density and breast cancer hospitalization was found in the northeast regions of the study area while breast cancer hospitalization was mainly related to urbanization in the western regions. Soil Cd pollution, road density, and urbanization were associated with breast cancer hospitalization in different regions. Findings in this study might provide valuable information for healthcare policies and intervention strategies for breast cancer.

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Cadmium tissue level in women diagnosed with breast cancer – A case control study

Cited by 27 publications

References 54 publications

Role of microRNAs in response to cadmium chloride in pancreatic ductal adenocarcinoma

Role of microRNAs in response to cadmium chloride in pancreatic ductal adenocarcinoma

Nickel’s Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs

Spatial patterns and the associated factors for breast cancer hospitalization in Fujian Province, China

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