Cadmium levels in human breast tissue and estradiol serum levels: Is there a connection?

Buha-Đorđević, Aleksandra; Anđelković, Milena; Kacavenda, Elena; Javorac, Dragana; Miljaković, Evica Antonijević; Marić, Đurđica; Baralić, Katarina; Đukić-Ćosić, Danijela; Ćurčić, Marijana; Antonijević, Biljana; Bulat, Zorica

doi:10.5937/arhfarm71-34280

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…According to the International Agency for Research on Cancer (IARC), As, Cd, chromium (Cr) (VI), nickel (Ni), and some of their compounds are classified as carcinogens to humans (group 1), while inorganic Pb and Pb compounds are classified as a probable human carcinogen (group 2A) [ 20 ]. In addition, several of these metal(loid)s are recognized as endocrine disruptor chemicals (EDCs) [ 16 , 21 , 22 , 23 , 24 ] that interfere with estrogen and androgen signaling pathways affecting the expression of genes involved in the growth and the secretory function of the prostate gland and contributing to prostate carcinogenesis [ 25 , 26 ]. Although the scanty epidemiologic data available indicate a possible contribution of several individual metal(loid)s to an increased risk of prostate cancer, only a few studies investigated their contribution to the increased PSA levels in presumably healthy men [ 10 , 12 , 13 , 27 ].…”

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confidence: 99%

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

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We studied the potential role of exposure to various metal(oid)s (As, Cd, Cr, Hg, Ni, and Pb) in prostate cancer. Two cohorts were established: the Croatian cohort, consisting of 62 cases and 30 controls, and the Serbian cohort, consisting of 41 cases and 61 controls. Blood/serum samples were collected. Levels of investigated metal(oid)s, various parameters of oxidative stress, and prostate-specific antigen (PSA) were determined in collected samples. A comparison of the measured parameters between 103 prostate cancer patients and 91 control men from both Croatian and Serbian cohorts showed significantly higher blood Hg, SOD, and GPx levels and significantly lower serum SH levels in prostate cancer patients than in controls. Correlation analyses revealed the significant relationship between certain parameters of oxidative stress and the concentrations of the measured metal(loid)s, pointing to the possible role of metal(oid)-induced oxidative stress imbalance. Furthermore, a significant inverse relationship was found between the blood Pb and the serum PSA in prostate cancer patients, but when the model was adjusted for the impacts of remaining parameters, no significant association between the serum PSA and the measured parameters was found. The results of the overall study indicate a substantial contribution of the measured metal(loid)s to the imbalance of the oxidant/antioxidant system. Although somewhat conflicting, the results of the present study point to the possible role of investigated metal(oid)s in prostate cancer, especially for Hg, since the obtained relationship was observed for both cohorts, followed by the disturbances in oxidative stress status, which were found to be correlated with Hg levels. Nevertheless, further studies in larger cohorts are warranted to explain and confirm the obtained results.

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Section: Introductionmentioning

confidence: 99%

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

et al. 2022

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“…However, the number of epidemiological studies in which BMD modeling is used is still restricted. This method has been employed successfully in the interpretation of human study data in some of our previously published articles ( 18 – 22 ). For example, we have demonstrated the existence of a dose-response relationship between mercury (Hg) in blood and all the measured thyroid hormones, with the most accurate modeling prediction for the effects on TSH in women, suggesting that even values greater than 0.626 µg/L could cause the increase of TSH in women ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

Nickel as a potential disruptor of thyroid function: benchmark modelling of human data

Maric,

Baralic,

Javorac

et al. 2023

Front. Endocrinol.

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IntroductionNickel (Ni) is one of the well-known toxic metals found in the environment. However, its influence on thyroid function is not explored enough. Hence, the aim of this study was to analyse the potential of Ni to disrupt thyroid function by exploring the relationship between blood Ni concentration and serum hormone levels (TSH, T4, T3, fT4 and fT3), as well as the parameters of thyroid homeostasis (SPINA-GT and SPINA-GD) by using correlation analysis and Benchmark (BMD) concept.MethodsNi concentration was measured by ICP-MS method, while CLIA was used for serum hormone determination. SPINA Thyr software was used to calculate SPINA-GT and SPINA-GD parameters. BMD analysis was performed by PROAST software (70.1). The limitations of this study are the small sample size and the uneven distribution of healthy and unhealthy subjects, limited confounding factors, as well as the age of the subjects that could have influenced the obtained results.Results and discussionThe highest median value for blood Ni concentration was observed for the male population and amounted 8,278 µg/L. Accordingly, the statistically significant correlation was observed only in the male population, for Ni-fT4 and Ni-SPINA-GT pairs. The existence of a dose-response relationship was established between Ni and all the measured parameters of thyroid functions in entire population and in both sexes. However, the narrowest BMD intervals were obtained only in men, for Ni - SPINA-GT pair (1.36-60.9 µg/L) and Ni - fT3 pair (0.397-66.8 µg/L), indicating that even 78.68 and 83.25% of men in our study might be in 10% higher risk of Ni-induced SPINA-GT and fT3 alterations, respectively. Due to the relationship established between Ni and the SPINA-GT parameter, it can be concluded that Ni has an influence on the secretory function of the thyroid gland in men. Although the further research is required, these findings suggest possible role of Ni in thyroid function disturbances.

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Environmental exposure to cadmium in breast cancer – association with the Warburg effect and sensitivity to tamoxifen

Tarhonska¹,

Janasik²,

Roszak³

et al. 2023

Biomedicine & Pharmacotherapy

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Cadmium levels in human breast tissue and estradiol serum levels: Is there a connection?

Cited by 7 publications

References 27 publications

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

Environmental Exposure to Metals, Parameters of Oxidative Stress in Blood and Prostate Cancer: Results from Two Cohorts

Nickel as a potential disruptor of thyroid function: benchmark modelling of human data

Environmental exposure to cadmium in breast cancer – association with the Warburg effect and sensitivity to tamoxifen

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