Environmental exposure to cadmium in breast cancer – association with the Warburg effect and sensitivity to tamoxifen

Tarhonska, Kateryna; Janasik, Beata; Roszak, Joanna; Kowalczyk, K.; Lesicka, Monika; Reszka, Edyta; Wieczorek, Edyta; Braun, Marcin; Agnieszka, Kołacińska-Wow; Skokowski, Jarosław; Kalinowski, Leszek; Jabłońska, Ewa

doi:10.1016/j.biopha.2023.114435

Cited by 3 publications

(3 citation statements)

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“…The main routes of elimination of xenobiotics and their metabolites are renal excretion, bile and fecal elimination, and pulmonary exhalation, but there are also secondary routes, such as sweat, hair and nails, breast milk, and tears [ 105 ]. For example, cadmium was detected at high concentration in BC tissue [ 108 ], as well as in the urine of patients with BC, urinary Cd being correlated with the expression of hypoxia-inducible factor 1 alpha (HIF1A) in BC tissues [ 109 ]. Other heavy metals, such as arsenic, chromium, lead, and mercury are considered to be carcinogens or co-carcinogens and have been detected in the urine of BC patients, even markedly increased [ 108 ].…”

Section: Absorption Distribution Metabolism/biotransformation Bioaccu...mentioning

confidence: 99%

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Breast Cancer Exposomics

Neagu,

Jayaweera,

Corrice

et al. 2024

Life

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We are exposed to a mixture of environmental man-made and natural xenobiotics. We experience a wide spectrum of environmental exposure in our lifetime, including the effects of xenobiotics on gametogenesis and gametes that undergo fertilization as the starting point of individual development and, moreover, in utero exposure, which can itself cause the first somatic or germline mutation necessary for breast cancer (BC) initiation. Most xenobiotics are metabolized or/and bioaccumulate and biomagnify in our tissues and cells, including breast tissues, so the xenobiotic metabolism plays an important role in BC initiation and progression. Many considerations necessitate a more valuable explanation regarding the molecular mechanisms of action of xenobiotics which act as genotoxic and epigenetic carcinogens. Thus, exposomics and the exposome concept are based on the diversity and range of exposures to physical factors, synthetic chemicals, dietary components, and psychosocial stressors, as well as their associated biologic processes and molecular pathways. Existing evidence for BC risk (BCR) suggests that food-borne chemical carcinogens, air pollution, ionizing radiation, and socioeconomic status are closely related to breast carcinogenesis. The aim of this review was to depict the dynamics and kinetics of several xenobiotics involved in BC development, emphasizing the role of new omics fields related to BC exposomics, such as environmental toxicogenomics, epigenomics and interactomics, metagenomics, nutrigenomics, nutriproteomics, and nutrimiRomics. We are mainly focused on food and nutrition, as well as endocrine-disrupting chemicals (EDCs), involved in BC development. Overall, cell and tissue accumulation and xenobiotic metabolism or biotransformation can lead to modifications in breast tissue composition and breast cell morphology, DNA damage and genomic instability, epimutations, RNA-mediated and extracellular vesicle effects, aberrant blood methylation, stimulation of epithelial–mesenchymal transition (EMT), disruption of cell–cell junctions, reorganization of the actin cytoskeleton, metabolic reprogramming, and overexpression of mesenchymal genes. Moreover, the metabolism of xenobiotics into BC cells impacts almost all known carcinogenic pathways. Conversely, in our food, there are many bioactive compounds with anti-cancer potential, exerting pro-apoptotic roles, inhibiting cell cycle progression and proliferation, migration, invasion, DNA damage, and cell stress conditions. We can conclude that exposomics has a high potential to demonstrate how environmental exposure to xenobiotics acts as a double-edged sword, promoting or suppressing tumorigenesis in BC.

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Section: Absorption Distribution Metabolism/biotransformation Bioaccu...mentioning

confidence: 99%

“…Evidence suggests that obese people accumulate more heavy metals compared to healthy people [ 118 ]. Thus, cadmium, among other heavy metals, is a widely spread compound that exerts estrogenic effects, acts as an endocrine disruptor, and accumulates in BC cells over time [ 109 ].…”

Section: Absorption Distribution Metabolism/biotransformation Bioaccu...mentioning

confidence: 99%

Breast Cancer Exposomics

Neagu,

Jayaweera,

Corrice

et al. 2024

Life

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“…Cd, which is classified as a toxic and a carcinogenic element, plays a role in the etiology of many cancer types [ 4 – 6 ]. Cd, which is believed to be effective in the development of oral cancer, is 1 of > 3,000 chemical components in tobacco products.…”

Section: Introductionmentioning

confidence: 99%

Effect of tobacco use on cadmium accumulation in the oral keratinized mucosa

Satir,

Kaya,

Ozsoy

2024

BMC Oral Health

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Background This cross-sectional study aimed to evaluate the effect of tobacco use on the accumulation of cadmium (Cd), a carcinogenic element, in the oral keratinized mucosa (OKM). Methods OKM samples were obtained by standard punch biopsy from nonsmokers (n = 19) and smokers (n = 21). Cd analysis was performed using inductively coupled plasma optical emission spectroscopy (ICP-OES). The calibration curve R2 values for three wavelengths (214,439, 226,502, and 228,802 nm) were at the level of 0.9999. The frequency of consumption of foods that are Cd sources, such as seafood, rice, and vegetables, was assessed in all patients. The age, sex, and nutritional habits of all patients and the frequency of tobacco consumption by smokers were recorded. The independent t-test, Mann–Whitney U test, Fisher’s exact test, and Spearman correlation test were used for the statistical analyses, and p < 0.05 was considered significant. Results Although the Cd levels in nonsmokers were higher than those in smokers, no statistically significant difference was found (p > 0.05). In smokers, a positive correlation was found between age and Cd level (r = 0.574, p = 0.006). No significant relationship was found between the groups in terms of nutrition or between the frequency of tobacco consumption and Cd accumulation. Conclusion The OKM may not have the characteristic cumulative accumulation in terms of toxic elements. Changes in the turnover rate, keratinization, and apoptotic mechanisms in the OKM with the thermal/chemical effects of tobacco may be responsible for the difference in Cd accumulation. Trial registration number TCTR20230206001/06 Feb 2023 (TCTR: Thai Clinical Trials Registry).

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