Cadmium inhibits repair of UV-, methyl methanesulfonate- and N-methyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells

Fatur, T; Lah, Tamara T.; Filipič, Metka

doi:10.1016/s0027-5107(03)00112-x

Cited by 75 publications

(35 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…EMS acts as a powerful alkyl donor, which provides an alkyl residue to the N7-glycodidic bond of guanine or thymine, resulting in G-T mismatch and introducing AT→GC and GC→AT transition mutations [18]. Alkylating agents such as methyl metansulfonate (MMS) and N-methyl-N-nitrosourea directly alkylate nitrogen and oxygen atoms of DNA bases [19]. Additionally, MMS forms covalent bonds with DNA and causes methylation of guanine [20].…”

Section: Discussionmentioning

confidence: 99%

Genoprotective Effects of Aqueous Extracts of Rosa Canina L. Fruits on Ethyl Methanesulfonate-Induced DNA Damage in Drosophila Melanogaster

Kasimoğlu¹,

Uysal²

2016

CSJ

View full text Add to dashboard Cite

Abstract. In this study, the possible genotoxic effects of ethyl methanesulfonate (EMS) which are one of alkylating agent and genoprotective effects of Rosa canina L. fruit water extract (RCwtr) was studied with Drosophila wing somatic mutation and recombination test (SMART). Five different application groups (distilled water, 1 mM EMS, 1% RCwtr, 3% RCwtr and 5% RCwtr) were formed with preliminary studies. 3-day-old transheterozygous larvae of mwh/flr 3 genotype of Drosophila melanogaster were fed chronically on the Drosophila instant medium (DIM) including the application groups. The wing slides of normal wing (mwh/flr 3 ) phenotype individuals were prepared and examined under light microscope (400X).As a result of experiments, the total clone frequencies of distilled water control group, 1 mM EMS, 1% RCwtr, 3% RCwtr and 5% RCwtr application groups were determined as 0. 3 ) bireylerin kanat preparatları hazırlanmış ve ışık mikroskobunda incelenmiştir (400X).Deneylerin sonucunda saf su kontrol grubu, 1 mM EMS, %1 RCsu, %3 RCsu ve %5 RCsu uygulama gruplarının toplam klon frekansları sırasıyla 0.15, 3.55, 2.58, 2.78 ve 2.20 olarak belirlenmiştir. Saf su kontrol grubu ve 1 mM EMS uygulama grupları arasındaki fark istatistiksel olarak önemlidir (P<0.05). RCsu uygulama gruplarından elde edilen sonuçlara göre ise, 1 mM EMS uygulama grubu ile karşılaştırıldığında her grubun toplam klon frekansı azalmıştır. 1mM EMS ve RCsu uygulama grupları arasındaki farkların istatistiksel olarak oldukça önemli olduğu bulunmuştur (P<0.05). Bulgular, Rosa canina L. bileşenlerinin doğal bir genomik koruyucu ürün olarak büyük bir potansiyele sahip olduğunu göstermektedir.

show abstract

Section: Discussionmentioning

confidence: 99%

Genoprotective Effects of Aqueous Extracts of Rosa Canina L. Fruits on Ethyl Methanesulfonate-Induced DNA Damage in Drosophila Melanogaster

Kasimoğlu¹,

Uysal²

2016

CSJ

View full text Add to dashboard Cite

show abstract

“…These effects may be explained by cadmium inhibition on several types of DNA repair: base excision repair, nucleotide excision repair, mismatch repair and the elimination of the premutagenic DNA precursor 8-oxodGTP. Regarding base excision repair, low concentrations of cadmium which did not generate oxidative damage as such, inhibited the repair of oxidative DNA damage in mammalian cells (Dally & Hartwig 1997;Fatur et al 2003). Exposure of human cells to sub-lethal concentrations of cadmium leads to a time and concentration dependent decrease in hOGG1 activity, i.e.…”

Section: Cadmiummentioning

confidence: 99%

Interactions by Carcinogenic Metal Compounds with DNA Repair Processes

Catalani¹,

Apostoli²

2011

Selected Topics in DNA Repair

View full text Add to dashboard Cite

“…Occupational inhalation exposures to heavy metals are associated with lung cancers (Fatur et al, 2003). Materials within the WTC dust included lead, asbestos, glass, as well as numerous aromatic ring compounds (Greenberger, 2008).…”

Section: Introductionmentioning

confidence: 99%

Comparison of World Trade Center dust with zinc acetate and lead oxide combinations to determine damage to human lung cells

Pattnaik¹

2013

J. Toxicol. Environ. Health Sci.

View full text Add to dashboard Cite

Cadmium inhibits repair of UV-, methyl methanesulfonate- and N-methyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells

Cited by 75 publications

References 34 publications

Genoprotective Effects of Aqueous Extracts of Rosa Canina L. Fruits on Ethyl Methanesulfonate-Induced DNA Damage in Drosophila Melanogaster

Genoprotective Effects of Aqueous Extracts of Rosa Canina L. Fruits on Ethyl Methanesulfonate-Induced DNA Damage in Drosophila Melanogaster

Interactions by Carcinogenic Metal Compounds with DNA Repair Processes

Comparison of World Trade Center dust with zinc acetate and lead oxide combinations to determine damage to human lung cells

Contact Info

Product

Resources

About