Cadmium induces apoptosis and genotoxicity in rainbow trout hepatocytes through generation of reactive oxygene species

Faverney, Christine Risso-de; Devaux, Alain; Lafaurie, M.; Girard, Jean‐Pierre; Bailly, Benjamin; Rahmani, Roger

doi:10.1016/s0166-445x(00)00154-5

Cited by 151 publications

(51 citation statements)

References 50 publications

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“…The results suggested that Cd has the potential to induce DNA damage in the liver of fish at very low concentrations. Shi et al (2005) reported that Cd (5 mg/L) could cause DNA damage in liver of goldfish C. auratus; DNA damage was also found in trout liver cells exposed to Cd at the concentrations of 0.11 to 1.12 mg/L (Risso De Faverney et al, 2001). These data also suggest that fish are sensitive to very low Cd concentrations.…”

Section: Discussionmentioning

confidence: 80%

Toxic effects of heavy metals (cadmium plus mercury) on haematological parameters and DNA damage in Lates calcarifer

Senthamilselvan¹

2012

J. Toxicol. Environ. Health Sci.

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The present study was carried out to evaluate the effects of toxic metals (cadmium plus mercury) on the haematology and DNA damage of fish, Lates calcarifer for every 24 h up to 96 h. A significant gradual decrease of haemoglobin (-35.01 to -24.11) and hematocrit (-35.01 to -31.78) was noted at acute concentration of cadmium plus mercury (3.0 ppm) as compared to that of control. The comet assay of fish blood cells exhibited a significant higher DNA damage and the highest OTM was observed in 96 h of acute mixed metals concentration. From this investigation, the results proved that the combined metal toxicity induced haematological and DNA damage of fish Lates calcarifer than individual metal toxicity.

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Section: Discussionmentioning

confidence: 80%

Toxic effects of heavy metals (cadmium plus mercury) on haematological parameters and DNA damage in Lates calcarifer

Senthamilselvan¹

2012

J. Toxicol. Environ. Health Sci.

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“…However in regard to the findings described in this manuscript it is possible that the lower ROS production could be due to the onset of apoptosis and thus lower cell numbers in the culture. Reactive oxygen species are known for their cytotoxicity in fish [43,44] and hence it is possible that the higher β-glucan concentrations induced ROS, causing apoptosis which then results in lower respiratory burst activity due to the reduced cell numbers.…”

Section: Discussionmentioning

confidence: 99%

Time and concentration dependency of MacroGard® induced apoptosis

Miest

Hoole

2015

Fish & Shellfish Immunology

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In previous studies an effect of β-glucan on apoptosis in fish was noted and in this investigation we determine the time and concentration dependency of this effect. Primary cell cultures of pronephric carp cells were incubated for 6, 24, 48 h with various concentrations ranging from 0 -1000 μg/ml of MacroGard ® β-glucan. Apoptosis was monitored via acridine orange staining. Results indicate a clear effect of time and concentration on the induction of apoptosis in vitro, with only concentration ≥ 500 μg/ml causing significantly higher percentages of apoptotic cells. Apoptosis was detected after 6 h. This concentration dependent effect has to be considered when studying apoptosis in relation to immunostimulation.

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“…Contaminants in the environment like heavy metals and herbicides have been implicated in modulating antioxidant defense systems thereby causing oxidative damage in aquatic life forms through the generation of ROS (Risso-de Facerney et al, 2001;Achuba and Osakwe, 2003;Liu et al, 2006;Monteiro et al, 2006). Fishes are equipped with a defensive system to counter the influence of ROS arising from the breakdown of chemicals and other xenobiotics.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Sublethal Concentrations of Glyphosate and Paraquat Herbicide in the African Catfish Clarias gariepinus

Ayanda¹

2018

IJAB

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Cadmium induces apoptosis and genotoxicity in rainbow trout hepatocytes through generation of reactive oxygene species

Cited by 151 publications

References 50 publications

Toxic effects of heavy metals (cadmium plus mercury) on haematological parameters and DNA damage in Lates calcarifer

Toxic effects of heavy metals (cadmium plus mercury) on haematological parameters and DNA damage in Lates calcarifer

Time and concentration dependency of MacroGard® induced apoptosis

Toxicity of Sublethal Concentrations of Glyphosate and Paraquat Herbicide in the African Catfish Clarias gariepinus

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