Cadmium(II) complexes of a hydrazone ligand: Synthesis, characterization, DNA binding, cyto- and genotoxicity studies

In vitro safety assessment of alkyl lactate esters in human umbilical vein endothelial cells (HUVECs)

“…DAPI is a standard nuclear stain which binds strongly to the DNA double helix at adenine thymine rich chromosomal regions. It is used to study and quantify DNA in cellular systems as staining nucleic acids [13] . Therefore, the nuclear morphology changes, including chromatin condensation and fragmentation of HUVECs due to the treatment with CL and SL, were investigated using DAPI staining.…”

Centro‐symmetric copper complex as a novel antitumor drug for therapeutic applications: Fabrication, structure, theoretical calculations, cytotoxicity, DNA binding/cleavage, and molecular docking

“…In the absorption spectroscopic experiment, the prepared Cu( AHC ) 2 complex has a fixed concentration, whereas DNA concentration has been increased gradually. The following equation could be used to compute the inherent binding affinity (K b ) from the observation of absorption data [ 37–39 ] : where [DNA] is the concentration of DNA in base pairs; the absorption coefficient (ε a ) was evaluated by A obsd /[M]; absorption coefficient (ε b ) means the extinction coefficient of the free compound, whereas absorption coefficient is the extinction coefficient of the compound when fully bound to DNA. By plotting [DNA]/(ε a − ε f ) versus [DNA] and detecting the ratio of slope to the intercept, the K b value could be determined.…”

“…In the absorption spectroscopic experiment, the prepared Cu(AHC) 2 complex has a fixed concentration, whereas DNA concentration has been increased gradually. The following equation could be used to compute the inherent binding affinity (K b ) from the observation of absorption data [37][38][39] :…”

Synthesis and Fundamental Characterization of Diverse Properties of Biocompatible Cd (II) Phosphor Complex for Cytotoxic Activity and Latent Fingerprint Detection

“…Among d 10 metals, the heavy metal cadmium forms a plethora of complexes with wide variety of coordination numbers ranging from four to eight . Although the fact that Cd (II) has an extensive human carcinogen effects and environmental contaminant properties, several researches showed that Cd (II) complexes had capability to induce apoptosis in a cancer cell‐specific way . On another hand, to date a significant number of scientific articles showed that the coordination compounds of the same ion can be interested as luminescent materials and fluorescence sensors to optoelectronics applications, such as in dye‐sensitized solar cells .…”