Cadmium exposure induces histological damage and cytotoxicity in the cardiovascular system of mice

Chou, Shing-Hsien; Lin, Hung-Chen; Chen, Shaowei; Tai, Y. T.; Jung, Shih‐Ming; Ko, Fu‐Hsiang; Pang, Jong‐Hwei S.; Chu, Pao‐Hsien

doi:10.1016/j.fct.2023.113740

Cited by 9 publications

(2 citation statements)

References 56 publications

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“…Additionally, Yazihan et al [36] reported that, in rat hearts, exposure to Cd causes apoptosis and inflammation, which was assessed using a variety of specialized biomarkers. Increased apoptosis was noted in the cardiac tissues of the Cd exposed embryos, which is consistent with previous findings [15,[42][43][44]. Myocardial fibrosis may be induced by cardiomyocyte death [45].…”

Section: Discussionsupporting

confidence: 91%

Cardiotoxicity of Cadmium and Its Effects on Heart Efficiency During Early and Late Chick Embryogenesis

Ali,

Awadalla,

Hamed

et al. 2024

Preprint

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A dangerous heavy metal that is non-degradable in the environment is cadmium (Cd). Many organs can accumulate cadmium, and adversely affect organ function and health. Cd is considered as a teratogenic and embryotoxic agent. This study aims to evaluate the teratogenicity of cadmium at concentrations lesser than the permissible and its effects on the heart during chick embryogenesis. Fertilized eggs of the chick Gallus domesticus were divided into; control, saline injected and four experimental groups injected with single doses of 5, 25, 50 or 75 µM of CdCl2. Histological observations of the heart before hatching and the cardiomyocytes after hatching were recorded. Morphometric measurements of heart chambers were achieved at 3, 4 and 6 days of incubation. Electrocardiograph and respiratory rate were recorded at tenth day. Different cardiac problems had been brought on by Cd. In comparison to controls, the heart looked to be much larger, and in certain cases, growth retardation was seen. Degeneration in heart walls and malformations of dorsal aorta were noticed. Morphomertrically, the width and wall thickness of heart chambers showed significant fluctuations between increase and decrease. Heart beats and respiratory rate significantly decreased compared to control. One of Cd toxicity is its ability to induce cellular oxidative stress. The heart in particular is very sensitive to oxidative stress. Cardiac oxidative stress might intensify heart failure and promote disease progression. Calcium is one of the components that needed for normal heart work. Cd might interfere with calcium metabolism by removing it from the body.

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Section: Discussionsupporting

confidence: 91%

Cardiotoxicity of Cadmium and Its Effects on Heart Efficiency During Early and Late Chick Embryogenesis

Ali,

Awadalla,

Hamed

et al. 2024

Preprint

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“…The authors of this study then extended their analysis to the aortic tissue and included in vitro cell experiments. Through this, the authors demonstrated damage to the intima and media of the aorta, potentially induced by the reduced viability of smooth muscle cells, as shown by in vitro experiments [ 162 ].…”

Section: The Role Of Trace Elements In Selected Cardiovascular Diseasesmentioning

confidence: 99%

The Role of Trace Elements in Cardiovascular Diseases

Wechselberger,

Messner,

Bernhard

2023

Toxics

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Essential trace elements play an important role in human physiology and are associated with various functions regulating cellular metabolism. Non-essential trace elements, on the other hand, often have well-documented toxicities that are dangerous for the initiation and development of diseases due to their widespread occurrence in the environment and their accumulation in living organisms. Non-essential trace elements are therefore regarded as serious environmental hazards that are harmful to health even in low concentrations. Many representatives of these elements are present as pollutants in our environment, and many people may be exposed to significant amounts of these substances over the course of their lives. Among the most common non-essential trace elements are heavy metals, which are also associated with acute poisoning in humans. When these elements accumulate in the body over years of chronic exposure, they often cause severe health damage in a variety of tissues and organs. In this review article, the role of selected essential and non-essential trace elements and their role in the development of exemplary pathophysiological processes in the cardiovascular system will be examined in more detail.

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Cadmium contributes to cardiac metabolic disruption by activating endothelial HIF1A-GLUT1 axis

Zhang,

Zheng,

Sun

et al. 2024

Cellular Signalling

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Cadmium exposure induces histological damage and cytotoxicity in the cardiovascular system of mice

Cited by 9 publications

References 56 publications

Cardiotoxicity of Cadmium and Its Effects on Heart Efficiency During Early and Late Chick Embryogenesis

Cardiotoxicity of Cadmium and Its Effects on Heart Efficiency During Early and Late Chick Embryogenesis

The Role of Trace Elements in Cardiovascular Diseases

Cadmium contributes to cardiac metabolic disruption by activating endothelial HIF1A-GLUT1 axis

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