Cadmium exposure induces a sex-dependent decline in left ventricular cardiac function

Fitch, Michael L.; Kabir, Raihan; Ebenebe, Obialunanma V; Taube, Nicole; Garbus, Haley; Sinha, Prithvi; Wang, Nadan; Mishra, Sumita; Lin, Brian L.; Muller, Grace K.; Kohr, Mark J.

doi:10.1016/j.lfs.2023.121712

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…Mice were sacrificed at 28 dpi using CO2 euthanasia. Echocardiogram At 28 dpi, sedated echocardiography was performed on sedated mice by a blinded investigator using a Vevo 2100 Ultrasound System (VisualSonics Inc.) as described previously 58 . At 33 dpi, echocardiography was performed on awake mice using a 40-MHz transducer (VisualSonics Inc.) as described previously 59 .…”

Section: Methods Mouse and Parasite Strains And Infectionmentioning

confidence: 99%

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A murine model ofTrypanosoma brucei-induced myocarditis and cardiac dysfunction

Crilly,

Zita,

Beaver

et al. 2023

Preprint

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Trypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). Cardiac symptoms are commonly reported in HAT patients, and intracardiac parasites with accompanying myocarditis have been observed in both natural hosts and animal models of T. brucei infection. However, despite the importance of T. brucei as a cause of cardiac dysfunction and the dramatic socioeconomic impact of African trypanosomiases in sub-Saharan Africa, there are currently no reproducible murine models of T. brucei-associated cardiomyopathy. We present the first clinically relevant, reproducible murine model of cardiac dysfunction in chronic T. brucei infection. Similar to humans, mice showed histological evidence of myocarditis and elevation of serum NT-proBNP. Serum NT-proBNP levels were elevated prior to the development of severe ventricular dysfunction. On flow cytometry, myocarditis was associated with an increase of most myocardial immune cell populations, including multiple T cell and macrophage subsets, corroborating the notion that T. brucei-associated cardiac damage is an immune-mediated event. This novel mouse model represents a powerful and practical tool to investigate the pathogenesis of T. brucei-mediated heart damage and support the development of therapeutic options for T. brucei-associated cardiac disease.

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Section: Methods Mouse and Parasite Strains And Infectionmentioning

confidence: 99%

“…At 28 dpi, sedated echocardiography was performed on sedated mice by a blinded investigator using a Vevo 2100 Ultrasound System (VisualSonics Inc.) as described previously 58 .…”

Section: Methodsmentioning

confidence: 99%

A murine model ofTrypanosoma brucei-induced myocarditis and cardiac dysfunction

Crilly,

Zita,

Beaver

et al. 2023

Preprint

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“…Mechanistically, the authors were able to show an influence of Cd on the ER, i.e., the decreased protein expression levels of sarco/endoplasmatic reticulum Ca 2+ -ATPase 2a (SERCA2a). The surprising results, however, were not the Cd-induced changes in the heart but that these occurred only in the male mice and not in the female mice [ 164 ].…”

Section: The Role Of Trace Elements In Selected Cardiovascular Diseasesmentioning

confidence: 99%

“…As can be seen from this section on Cd and its negative effects on cardiac muscle tissue, numerous studies have already been published that demonstrate both the effects and the mechanisms behind it. Nevertheless, further studies in this area are absolutely necessary, as not all effects and their consequences are yet fully understood, as shown by the recent study by Fitch et al [ 164 ].…”

Section: The Role Of Trace Elements In Selected Cardiovascular Diseasesmentioning

confidence: 99%

The Role of Trace Elements in Cardiovascular Diseases

Wechselberger,

Messner,

Bernhard

2023

Toxics

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Essential trace elements play an important role in human physiology and are associated with various functions regulating cellular metabolism. Non-essential trace elements, on the other hand, often have well-documented toxicities that are dangerous for the initiation and development of diseases due to their widespread occurrence in the environment and their accumulation in living organisms. Non-essential trace elements are therefore regarded as serious environmental hazards that are harmful to health even in low concentrations. Many representatives of these elements are present as pollutants in our environment, and many people may be exposed to significant amounts of these substances over the course of their lives. Among the most common non-essential trace elements are heavy metals, which are also associated with acute poisoning in humans. When these elements accumulate in the body over years of chronic exposure, they often cause severe health damage in a variety of tissues and organs. In this review article, the role of selected essential and non-essential trace elements and their role in the development of exemplary pathophysiological processes in the cardiovascular system will be examined in more detail.

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Physical activity can reduce the risk of blood cadmium and blood lead on stroke: Evidence from NHANES

Deng,

Liu,

et al. 2024

Toxicology and Applied Pharmacology

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Cadmium exposure induces a sex-dependent decline in left ventricular cardiac function

Cited by 5 publications

References 35 publications

A murine model ofTrypanosoma brucei-induced myocarditis and cardiac dysfunction

A murine model ofTrypanosoma brucei-induced myocarditis and cardiac dysfunction

The Role of Trace Elements in Cardiovascular Diseases

Physical activity can reduce the risk of blood cadmium and blood lead on stroke: Evidence from NHANES

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