Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease

Khlifi, Rim; Olmedo, Pablo; Gil, Fernando; Hammami, B.; Hamza-Chaffai, Amel

doi:10.1007/s11356-014-3619-8

Cited by 13 publications

(13 citation statements)

References 39 publications

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“…Twelve studies used a case-control study design. 7,15,[28][29][30][31][32][33][34][35][36][37] A cross-sectional design (n = 12) was also used in many studies. [38][39][40][41][42][43][44][45][46][47][48][49] Other study designs included a quasi-experimental design (n = 3), [50][51][52] a time series (n = 2), 14,53 cohort (n = 2), 54,55 single group pretest-postest (n = 2), 56,57 experimental (n = 2), 58,59 a crossover design (n = 2), 60,61 secondary analysis (n = 1), 62 repeated measures (n = 1), 63 and case report (n = 1).…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of Effects of Waterpipe Smoking on Cardiovascular and Respiratory Health Outcomes

et al. 2016

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BACKGROUNDWaterpipe smoking (WPS) is a social custom common in many Middle Eastern, North African, and Asian countries and has become increasingly popular in the US, especially among youth; however, WPS smoking may be increasing in the US adult population as well. There is a common belief among waterpipe (WP) smokers that WPS is less harmful than smoking cigarettes. Thus, this review aims to systematically explore the literature on the effects of WP tobacco smoking with a particular focus on cardiovascular and respiratory health outcomes as well as on oxidative stress, immunity, and cell cycle interference health outcomes.METHODOLOGYWe conducted a systematic review, guided by the criteria of The Preferred Reporting Items for Systematic Reviews and Meta-Analyses, using the following online databases MEDLINE, CINAHL, ScienceDirect, PMC, and Cochrane Library. Results were summarized qualitatively.RESULTSForty studies met the inclusion criteria established for this review. Based on the existing evidence, several cardiovascular and respiratory physiologic health indicators and conditions have been shown to be negatively affected by WPS. In addition to the effects of nicotine and chemical toxicant exposures, WPS was significantly associated with an increase in heart rate, blood pressure, and lower pulmonary function test results, as well as a number of health conditions such as lung cancer, alterations in oxidative stress, immunity, and cell cycle interference.CONCLUSIONThe current literature provides evidence that WPS is associated with a number of negative health indicators and outcomes. There is need for more research related to WPS and its effects on health so that appropriate campaigns and prevention interventions can be implemented to control the epidemic increase of WPS in the US.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of Effects of Waterpipe Smoking on Cardiovascular and Respiratory Health Outcomes

et al. 2016

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“…No significant association has been found between high nickel blood levels and the risk of nasosinusal polyposis in a case–control study of Tunisian patients (Khlifi et al., 2015) and between serum nickel concentrations and brain damage markers and serum hormones in a case–control study with male Russian patients suffering from acute ischaemic stroke (Skalny et al., 2017). In Chinese pregnant women, a significant association was observed for nickel in blood with a decrease in free thyroxine using single‐metal models.…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of nickel in food and drinking water

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

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The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance and newly available scientific information. More than 47,000 analytical results on the occurrence of nickel were used for calculating chronic and acute dietary exposure. An increased incidence of postimplantation loss in rats was identified as the critical effect for the risk characterisation of chronic oral exposure and a BMDL 10 of 1.3 mg Ni/kg body weight (bw) per day was selected as the reference point for the establishment of a tolerable daily intake (TDI) of 13 lg/kg bw. Eczematous flare-up reactions in the skin elicited in nickel-sensitised humans, a condition known as systemic contact dermatitis, was identified as the critical effect for the risk characterisation of acute oral exposure. A BMDL could not be derived, and therefore, the lowest-observed-adverse-effect-level of 4.3 lg Ni/kg bw was selected as the reference point. The margin of exposure (MOE) approach was applied and an MOE of 30 or higher was considered as being indicative of a low health concern. The mean lower bound (LB)/upper bound (UB) chronic dietary exposure was below or at the level of the TDI. The 95th percentile LB/UB chronic dietary exposure was below the TDI in adolescents and in all adult age groups, but generally exceeded the TDI in toddlers and in other children, as well as in infants in some surveys. This may raise a health concern in these young age groups. The MOE values for the mean UB acute dietary exposure and for the 95th percentile UB raises a health concern for nickel-sensitised individuals. The MOE values for an acute scenario regarding consumption of a glass of water on an empty stomach do not raise a health concern.

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“…In a case report in 2014, it is observed that a 26-years-old chemist working with Ni nanoparticles has facial flushing and upper airway symptoms such as nasal congestion, throat irritation and post nasal drip [9]. A study which is performed by Khlifi et al suggests that toxic heavy metals such as cadmium and Ni have possible effects on development of nasosinusal polyposis disease [10]. Various long term studies have provided different results about the relationship between Ni exposure with lung and nasal cancers [11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Rare occupational cause of nasal septum perforation: Nickel exposure

Bolek

Erden

Külekçi

et al. 2017

Int J Occup Med Environ Health

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Many etiologies are held accountable for nasal septum perforations. Topical nasal drug usage, previous surgeries, trauma, nose picking, squamous cell carcinoma, some rheumatological disorders such as granulomatosis with polyangiitis (Wegener granulomatosis), some infectious diseases such as syphilis and leprosy are among the causes of the perforations. Occupational heavy metal exposures by inhalation rarely may also cause nasal septum perforation. Here, we present a 29-year-old patient without any known diseases, who is a worker at a metallic coating and nickel-plating factory, referred for investigation of his nasal cartilage septum perforation from an otorhinolaryngology clinic. The patient questioning, physical examination and laboratory assessment about rheumatic and infectious diseases were negative. There was a metallic smell in the breath during the physical examination. The analysis showed serum nickel level at 31 μg/l and urine nickel at 18 μg/l (84.11 μg/g creatinine). Other possible serum and urine heavy metal levels were within normal ranges. Nickel exposure is usually together with other heavy metals (chromium or cadmium), it is rarely alone. Nickel ingested by inhalation usually leads to respiratory problems such as reduced olfactory acuity, ulcers, septum perforation or tumors of the nasal sinuses. This case demonstrates the importance of occupational anamnesis and awareness of diagnosis. Int J Occup Med Environ Health 2017;30(6):963 -967

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Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease

Cited by 13 publications

References 39 publications

A Systematic Review of Effects of Waterpipe Smoking on Cardiovascular and Respiratory Health Outcomes

A Systematic Review of Effects of Waterpipe Smoking on Cardiovascular and Respiratory Health Outcomes

Update of the risk assessment of nickel in food and drinking water

Rare occupational cause of nasal septum perforation: Nickel exposure

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