Cadmium and lung cancer mortality accounting for simultaneous arsenic exposure

Park, Robert M.; Stayner, Leslie T.; Petersen, Martin R.; Finley-Couch, Melissa; Hornung, Richard; Rice, Carol

doi:10.1136/oemed-2011-100149

Cited by 40 publications

(31 citation statements)

References 25 publications

(34 reference statements)

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“…When the model intercept was constrained to avoid implausibly low background rates, both of these rate ratios were diminished, but remained statistically significant. Park et al (2012) similarly observed implausibly low model intercepts in some Poisson regression models of the lung cancer SMR in a cohort of workers exposed to cadmium and arsenic; to account for this, they additionally reported rate ratios adjusted to a common unexposed SMR of 0.8. In our study, when workers potentially exposed to TCE were excluded from the analysis, the stomach cancer rate ratio was attenuated (but remained statistically significant), indicating that some of the increased risk was due to confounding by TCE exposure.…”

Section: Discussionmentioning

confidence: 99%

Mortality among 24,865 workers exposed to polychlorinated biphenyls (PCBs) in three electrical capacitor manufacturing plants: A ten-year update

Ruder

Hein

Hopf

et al. 2014

International Journal of Hygiene and Environmental Health

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The objective of this analysis was to evaluate mortality among a cohort of 24,865 capacitormanufacturing workers exposed to polychlorinated biphenyls (PCBs) at plants in Indiana, Massachusetts, and New York and followed for mortality through 2008. Cumulative PCB exposure was estimated using plant-specific job-exposure matrices. External comparisons to US and state-specific populations used standardized mortality ratios, adjusted for gender, race, age and calendar year. Among long-term workers employed 3 months or longer, within-cohort comparisons used standardized rate ratios and multivariable Poisson regression modeling. Through 2008, more than one million person-years at risk and 8749 deaths were accrued. Among long-term employees, all-cause and all-cancer mortality were not elevated; of the a priori outcomes assessed only melanoma mortality was elevated. Mortality was elevated for some outcomes of a priori interest among subgroups of long-term workers: all cancer, intestinal cancer and amyotrophic lateral sclerosis (women); melanoma (men); melanoma and brain and nervous system cancer (Indiana plant); and melanoma and multiple myeloma (New York plant). Standardized rates of stomach and uterine cancer and multiple myeloma mortality increased with estimated cumulative PCB exposure. Poisson regression modeling showed significant associations with estimated cumulative PCB exposure for prostate and stomach cancer mortality. For other outcomes of a priori interest -rectal, liver, ovarian, breast, and thyroid cancer, non-Hodgkin lymphoma, Alzheimer disease, and Parkinson disease -neither elevated mortality nor positive associations with PCB exposure were observed. Associations between estimated cumulative PCB exposure and stomach, uterine, and prostate cancer and myeloma mortality confirmed our previous positive findings.

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Section: Discussionmentioning

confidence: 99%

Mortality among 24,865 workers exposed to polychlorinated biphenyls (PCBs) in three electrical capacitor manufacturing plants: A ten-year update

Ruder

Hein

Hopf

et al. 2014

International Journal of Hygiene and Environmental Health

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“…According to the Third National Health and Nutrition Examination Survey (NHANES III), cadmium appears to be associated with overall cancer mortality in men and women (Adams et al, 2012). Another study was also showed that cadmium was an independent factor effecting mortality in lung cancer (Park et al, 2012). Arsenic exposition is also related mortality in patients with lung cancer compared with the controls (Nakadaira et al, 2002).…”

Section: Discussionmentioning

confidence: 91%

Association of Cadmium but not Arsenic Levels in Lung Cancer Tumor Tissue with Smoking, Histopathological Type and Stage

Demir¹,

Enön²,

Türksoy³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: To evaluate association of lung cancer with arsenic and cadmium levels measured in tumor tissue. Materials and Methods: Ninety-five patients with lung cancer tumor tissue obtained surgically were included in this study. Arsenic and cadmium levels were measured and levels of metals were compared among types of lung cancer and with reference to patient data. Results: The histopathologic diagnoses of the 95 cases were SCC, 49, adenocarcinoma, 28, large cell, 11 and SCLC, 1. Mean tumor arsenic and cadmium levels were 149.3±129.1µg/kg and 276.3±219.3µg/kg, respectively. Cadmium levels were significantly associated with smoking (p=0.02), histopathologic type (p=0.005), and TNM staging (r=0.325; p=0.001), although arsenic was not related to any parameter (p>0.05). There was no relation between metal levels and mortality (p>0.05). Conclusions:We found a significant association between tumor cadmium levels of patients with lung cancer and smoking, histopathologic type and staging, although there was no relation with arsenic levels.

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“…The lack of such an effect in other studies (see Chapter 32) may be due to absence of simultaneous exposure to arsenic. Epidemiological studies into lung cancer mortality from coexposure to cadmium and arsenic (Park et al, 2012) reported that cadmium exerts a statistically significant effect on this health endpoint that is independent of that resulting from arsenic exposure.…”

Section: Joint Action Of Cadmium and Other Metalsmentioning

confidence: 98%

“…Such interactions are likely to exist for cancer but have so far only been demonstrated for noncancerous effects among human populations exposed to both of these elements in China (Figure 1). Epidemiological studies of lung cancer mortality from coexposures to cadmium and arsenic (Park et al, 2012) reported that cadmium exerts a statistically significant effect on this health endpoint that is independent of that from arsenic exposure (e.g.. statistical analysis shows that both cadmium and arsenic exert discernible effects but that toxicity is increased by combined exposures).…”

Section: Arsenicmentioning

confidence: 98%

Interactions and Mixtures in Metal Toxicology

Nordberg¹,

Gerhardsson²,

Mumtaz³

et al. 2015

Handbook on the Toxicology of Metals

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Cadmium and lung cancer mortality accounting for simultaneous arsenic exposure

Abstract: These findings support an independent effect for cadmium in risk of lung cancer mortality. 1/1000 excess lifetime risk of lung cancer death is predicted from an airborne exposure of about 2.4 μg/m(3) Cd.

Cited by 40 publications

References 25 publications

Mortality among 24,865 workers exposed to polychlorinated biphenyls (PCBs) in three electrical capacitor manufacturing plants: A ten-year update

Mortality among 24,865 workers exposed to polychlorinated biphenyls (PCBs) in three electrical capacitor manufacturing plants: A ten-year update

Association of Cadmium but not Arsenic Levels in Lung Cancer Tumor Tissue with Smoking, Histopathological Type and Stage

Interactions and Mixtures in Metal Toxicology

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