Cadmium and copper display different responses towards oxidative stress in the kidney of the sea bass Dicentrarchus labrax

Roméo, Michèle; Bennani, N.; Gnassia‐Barelli, M.; Lafaurie, M.; Girard, Jean‐Pierre

doi:10.1016/s0166-445x(99)00039-9

Cited by 283 publications

(122 citation statements)

References 25 publications

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“…Cadmium also affects antioxidant enzymes, especially SOD and CAT, and is able to displace copper and iron in various proteins, freeing these metals to then participate in the Fenton reaction (Ercal et al, 2001). Reduced CAT activity following Cd exposure has been reported by Romeo et al (2000) in the kidney of the sea bass Dicentrarchus labrax. This decreased activity was explained by the authors as the direct binding of cadmium to CAT.…”

Section: Cadmiummentioning

confidence: 85%

Metals as a cause of oxidative stress in fish: a review

Ševčíková¹,

Modrá²,

Slaninova³

et al. 2011

Vet. Med. - Czech

298

106

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ABSTRACT:This review summarizes the current knowledge on the contribution of metals to the development of oxidative stress in fish. Metals are important inducers of oxidative stress in aquatic organisms, promoting formation of reactive oxygen species through two mechanisms. Redox active metals generate reactive oxygen species through redox cycling, while metals without redox potential impair antioxidant defences, especially that of thiol-containing antioxidants and enzymes. Elevated levels of reactive oxygen species lead to oxidative damage including lipid peroxidation, protein and DNA oxidation, and enzyme inactivation. Antioxidant defences include the enzyme system and low molecular weight antioxidants. Metal-binding proteins, such as ferritin, ceruloplasmin and metallothioneins, have special functions in the detoxification of toxic metals and also play a role in the metabolism and homeostasis of essential metals. Recent studies of metallothioneins as biomarkers indicate that quantitative analysis of mRNA expression of metallothionein genes can be appropriate in cases with elevated levels of metals and no evidence of oxidative damage in fish tissue. Components of the antioxidant defence are used as biochemical markers of oxidative stress. These markers may be manifested differently in the field than in results found in laboratory studies. A complex approach should be taken in field studies of metal contamination of the aquatic environment. Keywords: ROS; metallothioneins; glutathion; superoxide dismutase; antioxidant defenceList of abbreviations ALA-D = aminolevulinic acid dehydratase; BNF = β-naphthoflavone; CAT = catalase; GPx = glutathione peroxidise; GR = glutathione reductase; GSH = glutathione; GSSG = glutathione disulphide; GST = glutathione S-transferase; LPO = lipid peroxidation; MDA = malondialdehyde; MTs = metallothioneins; NADPH = nicotinamidadeninedinucleotide phosphate (reduced); ROS = reactive oxygen species; SOD = superoxide dismutase

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Section: Cadmiummentioning

confidence: 85%

Metals as a cause of oxidative stress in fish: a review

Ševčíková¹,

Modrá²,

Slaninova³

et al. 2011

Vet. Med. - Czech

298

106

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“…These excessive heavy metals can induce adverse effects to organisms and pose risks on marine environments (Lavery et al, 2009;Romeo et al, 2000). Therefore, it is necessary to carry out biomonitoring for heavy metal pollution in pollution on the basis of high accumulation of various heavy metals including Cd, Zn, Cu, Pb, Fe, Cr, Co and Ni (Ji et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Toxicological evaluation of two pedigrees of clam Ruditapes philippinarum as bioindicators of heavy metal contaminants using metabolomics

Cao

2015

Environmental Toxicology and Pharmacology

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EcotoxicologyHeavy metals Metabolomics NMR a b s t r a c t Heavy metal pollution has been of great concern in the Bohai marine environment. Manila clam Ruditapes philippinarum has been used as a bioindicator in marine toxicology. In this study, NMR-based metabolomics was used to ascertain whether there were significant biological differences between two dominant pedigrees (White and Zebra) of clam and evaluate the suitability of two pedigrees for marine environmental toxicology, together with antioxidant enzymatic analysis. Our results indicated that there were significant biological differences between White and Zebra clams based on the metabolic profiles and antioxidant enzyme activities. In details, the metabolic profiles showed higher levels of amino acids and succinate in Zebra clam digestive glands and higher levels of ATP in White clam digestive glands, respectively. The superoxide dismutase activities in control White and Zebra clam samples were significantly different. Additionally, White clam was more sensitive to Cd based on the significant accumulation of Cd, antioxidant enzymatic alterations and sensitive metabolic changes. Overall, we concluded that White clam could be a preferable bioindicator for marine environmental toxicology.

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“…Copper is essential metal, and is necessary for organisms to form many enzymes, such as Cu/Zn-SOD [23]. Therefore, at low concentrations, copper may have a protective effect by forming Cu/Zn-SOD.…”

Section: Discussionmentioning

confidence: 99%

125 Toxic Effects of Chronic Sub-Lethal Cu 2+ , Pb 2+ and Cd 2+ on Antioxidant Enzyme Activities in Various Tissues of the Blood Cockle, Anadara granosa

Peng¹,

Zhao²,

Han³

et al. 2015

JRST

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Blood cockles, Anadara granosa, live in coastal mudflats under threaten of low-dose chronic heavy metal exposure. The toxic effects of low dose chronic copper (7.1, 14.2, and 28.4 μg/L), lead (43, 86, and 172 μg/L), and cadmium (55, 110, and 220 μg/L) exposure on the antioxidant enzyme activities in gill, gonad and digestive gland of A. granosa were investigated in this study. The activities of superoxide dismutases (SOD), catalase (CAT) and glutathione peroxidase (GPx) fluctuated with increased copper, lead, and cadmium exposure time. The heavy metal exposure concentration and duration (7, 14, 21, and 28 days) showed significant effects on the antioxidant enzyme activities in tested tissues. Moreover, the activities of tested antioxidant enzymes not only varied among different tissues, but also were dependent on metal species, suggesting the reactive oxygen species (ROS) may be produced through different mechanisms for different metals in various tissues. Our results indicate that the application of antioxidant enzyme activities as endpoints in toxicology bioassays for chronic sub-lethal metals must be done with caution due to their complicated produce mechanisms.

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Cadmium and copper display different responses towards oxidative stress in the kidney of the sea bass Dicentrarchus labrax

Cited by 283 publications

References 25 publications

Metals as a cause of oxidative stress in fish: a review

Metals as a cause of oxidative stress in fish: a review

Toxicological evaluation of two pedigrees of clam Ruditapes philippinarum as bioindicators of heavy metal contaminants using metabolomics

125 Toxic Effects of Chronic Sub-Lethal Cu 2+ , Pb 2+ and Cd 2+ on Antioxidant Enzyme Activities in Various Tissues of the Blood Cockle, Anadara granosa

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